Bisphenol A and its alternatives in Austrian thermal paper receipts, and the migration from reusable plastic drinking bottles into water and artificial saliva using UHPLC-MS/MS

Banaderakhshan, Rojin; Kemp, P.H.; Breul, Lea; Steinbichl, Philipp; Hartmann, Christina; Fürhacker, Maria

doi:10.1016/j.chemosphere.2021.131842

Cited by 48 publications

(29 citation statements)

References 18 publications

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“…Tetramethyl bisphenol A, BPFL, and 4‐phenylphenol are classified as alternative substances of BPA, and these analogs are introduced mainly for usage in thermal paper, polymers, polycarbonates, and fire retardants (Keminer et al, 2020). Because these applications cause exposure of chemicals in the environment, the analogs have been detected in water and sediment samples from lakes or rivers (Banaderakhshan et al, 2022; Chafi et al, 2022; Jin & Zhu, 2016). These chemicals have been reported to have endocrine disruptor potential by exhibiting anti‐ or estrogenic activities in humans (Keminer et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Species Differences in Response to Binding Interactions of Bisphenol A and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish

Park

Singh

Ryu

et al. 2022

Enviro Toxic and Chemistry

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Adverse impacts associated with the interactions of numerous endocrine-disruptor chemicals (EDCs) with estrogen receptor 1 play a pivotal role in reproductive dysfunction. The predictive studies on these interactions thus are crucial in the risk assessment of EDCs but rely heavily on the accuracy of specific protein structure in three dimensions. As the threedimensional (3D) structure of zebrafish estrogen receptor 1 (zEsr1) is not available, the 3D structure of zEsr1 ligand-binding domain (zEsr1-LBD) was generated using MODELLER and its quality was assessed by the PROCHECK, ERRAT, ProSA, and Verify-3D tools. After the generated model was verified as reliable, bisphenol A and its analogs were docked on the zEsr1-LBD and human estrogen receptor 1 ligand-binding domain (hESR1-LBD) using the Discovery Studio and Autodock Vina programs. The molecular dynamics followed by molecular docking were simulated using the Nanoscale Molecular Dynamics program and compared to those of the in vitro reporter gene assays. Some chemicals were bound with an orientation similar to that of 17β-estradiol in both models and in silico binding energies showed moderate or high correlations with in vitro results (0.33 ≤ r 2 ≤ 0.71). Notably, hydrogen bond occupancy during molecular dynamics simulations exhibited a high correlation with in vitro results (r 2 ≥ 0.81) in both complexes. These results show that the combined in silico and in vitro approaches is a valuable tool for identifying EDCs in different species, facilitating the assessment of EDC-induced reproductive toxicity.

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Section: Introductionmentioning

confidence: 99%

Species Differences in Response to Binding Interactions of Bisphenol A and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish

Park

Singh

Ryu

et al. 2022

Enviro Toxic and Chemistry

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“…Polycarbonate plastics are often used in containers that store food and beverages, such as water bottles [ 10 ]. BPA is also used as a color developer to make the thermal paper on which most receipts are printed [ 13 ]. BPA is considered safe for its intended use because its estimated human exposure levels do not exceed the derived “safe” levels, the tolerable daily intake (TDI) [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, using BPA to produce baby feeding bottles has been banned in the United States (US) and the European Union (EU) due to uncertainty about the effect of BPA exposure in infants [ 14 ]. In line with this, the European Food Safety Authority (EFSA) reduced the TDI of BPA from 50 to 4 μg/kg body weight (bw)/day in 2015, and the EU included BPA on the list of candidate substances of serious concern in 2017, which is the first step toward restricting the importation and use of a chemical [ 13 ]. Thus, health concerns regarding BPA exposure remain.…”

Section: Introductionmentioning

confidence: 99%

Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment

Kwon

2022

Cancers

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BPA, a chemical used in the preparation of polycarbonate plastics, is an endocrine disruptor. Exposure to BPA has been suggested to be a risk factor for breast cancer because of its potential to induce estrogen receptor signaling in breast cancer cells. More recently, it has been recognized that BPA also binds to the G protein-coupled estrogen receptor and other nuclear receptors, in addition to estrogen receptors, and acts on immune cells, adipocytes, and fibroblasts, potentially modulating the TME. The TME significantly impacts the behavior of cancer cells. Therefore, understanding how BPA affects stromal components in breast cancer is imperative to adequately assess the association between exposure to BPA and the risk of breast cancer. This review examines the effects of BPA on stromal components of tumors to highlight their potential role in the carcinogenic effect of BPA. As a result, I propose considerations for the risk assessment of BPA exposure and studies needed to improve understanding of the TME-mediated, breast cancer-promoting effect of BPA.

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“…BPA has been detected in packaged foods, drinking water, dust, sewage sludge, urine, serum, etc. [ 2 , 7 ]. A mean value of 8.99 ng/g BPA was tested in 45 vegetable samples [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of Binary Mixtures of Bisphenol A and Heavy Metals

Liao

Zheng

et al. 2022

Toxics

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Bisphenol A (BPA) and heavy metals are widespread contaminants in the environment. However, the combined toxicities of these contaminants are still unknown. In this study, the bioluminescent bacteria Vibrio qinghaiensis Q67 was used to detect the single and combined toxicities of BPA and heavy metals, then the joint effects of these contaminants were evaluated. The results show that chronic toxicities of chromium (Cr), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg), nickel (Ni), and BPA were time–dependent; in fact, the acute toxicities of these contaminants were stronger than the chronic toxicities. Furthermore, the combined toxicities of BPA and heavy metals displayed BPA + Hg > BPA + Cr > BPA + As > BPA + Ni > BPA + Pb > BPA + Cd in the acute test and BPA + Hg > BPA + Cd > BPA + As > BPA + Cd in the chronic test, which suggested that the combined toxicity of BPA and Hg was stronger than that of other mixtures in acute as well as chronic tests. Additionally, both CA and IA models underestimated the toxicities of mixtures at low concentrations but overestimated them at high concentrations, which indicates that CA and IA models were not suitable to predict the toxicities of mixtures of BPA and heavy metals. Moreover, the joint effects of BPA and heavy metals mainly showed antagonism and additive in the context of acute exposure but synergism and additive in the context of chronic exposure. Indeed, the difference in the joint effects on acute and chronic exposure can be explained by the possibility that mixtures inhibited cell growth and luminescence in chronic cultivation. The chronic toxicity of the mixture should be considered if the mixture results in the inhibition of the growth of cells.

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Bisphenol A and its alternatives in Austrian thermal paper receipts, and the migration from reusable plastic drinking bottles into water and artificial saliva using UHPLC-MS/MS

Cited by 48 publications

References 18 publications

Species Differences in Response to Binding Interactions of Bisphenol A and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish

Species Differences in Response to Binding Interactions of Bisphenol A and its Analogs with the Modeled Estrogen Receptor 1 and In Vitro Reporter Gene Assay in Human and Zebrafish

Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment

Acute and Chronic Toxicity of Binary Mixtures of Bisphenol A and Heavy Metals

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