Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: A systematic review of epidemiologic research

LaKind, Judy S.; Goodman, Michael; Mattison, Donald R.

doi:10.3109/10408444.2013.860075

Cited by 131 publications

(75 citation statements)

References 112 publications

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“…First, since fasting status (≥ 10 or < 10 hours) and time of urine collection (morning, afternoon, or evening) may be associated with urinary BPA levels, 26,27 we assessed potential confounding by these variables. Second, we restricted our models to respondents aged 18 to 64 years, as standard BMI and waist circumference classifications may not be applicable to elderly (Table 4), with slightly stronger associations in females (p for interaction > .05; data not shown).…”

Section: Resultsmentioning

confidence: 99%

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Minh

Chang

Mendez

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction Exposure to bisphenol A (BPA) has been shown to affect lipid metabolism and promote weight gain in animal studies. Recent epidemiological studies also support a link between BPA and obesity in human populations, although many were limited to a single adiposity measure or have not considered potential confounding by dietary factors. The purpose of this study is to examine associations between urinary BPA and adiposity measures in a nationally representative sample of Canadian adults. Methods We performed analyses using biomonitoring and directly measured anthropometric data from 4733 adults aged 18 to 79 years in the Canadian Health Measures Survey (2007–2011). We used multinomial and binary logistic regression models to estimate associations of urinary BPA with body mass index (BMI) categories (overweight vs. under/normal weight; obesity vs. under/normal weight) and elevated waist circumference (males: ≥ 102 cm; females: ≥ 88 cm), respectively, while controlling for potential confounders. Linear regression analyses were also performed to assess associations between urinary BPA and continuous BMI and waist circumference measures. Results Urinary BPA was positively associated with BMI-defined obesity, with an odds ratio of 1.54 (95% confidence interval [CI]: 1.002–2.37) in the highest (vs. lowest) BPA quartile (test for trend, p = .041). Urinary BPA was not associated with elevated waist circumference defined using standard cut-offs. Additionally, each natural-log unit increase in urinary BPA concentration was associated with a 0.33 kg/m2 (95% CI: 0.10– 0.57) increase in BMI and a 1.00 cm (95% CI: 0.34–1.65) increase in waist circumference. Conclusion Our study contributes to the growing body of evidence that BPA is positively associated with obesity. Prospective studies with repeated measures are needed to address temporality and improve exposure classification.

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Section: Resultsmentioning

confidence: 99%

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Minh

Chang

Mendez

et al. 2017

Health Promot Chronic Dis Prev Can

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“…dioxins and polychlorinated biphenyls) to those that are metabolized and/or eliminated within hours or days. Short-lived chemicals present unique challenges for exposure assessment and for study design and interpretation LaKind et al 2014b). TCS is an important short-lived chemical because of widespread human exposure and public concern surrounding its use (http:// www.nytimes.com/2013/12/17/health/fda-to-require-proofthat-antibacterial-soaps-are-safe.html).…”

Section: Discussionmentioning

confidence: 99%

“…We followed the literature review protocol described in previous publications LaKind et al 2014b). Each study that met the inclusion criteria was examined independently by two coauthors (MG and JSL).…”

Section: Data Extractionmentioning

confidence: 99%

“…However, the utility of epidemiologic data as the basis for regulation is largely dependent on the strength, coherence, and quality of the published studies (OHAT 2015;USEPA 2016). While the epidemiologic studies exploring health outcomes and associations with environmental chemical exposures are numerous, recent publications, and governmental reports indicate that informed decision-making may be difficult due to the variable quality of the available evidence and the lack of consistency in terms of specific hypotheses tested, study methods, and reporting of results (Goodman et al 2010Youngstrom et al 2011;LaKind et al 2014aLaKind et al , 2014bLaKind et al , 2015aLaKind et al , 2015bRooney et al 2014;USEPA 2016). In this communication, we offer a systematic examination of the epidemiologic literature on one specific chemical of interest -triclosan (TCS).…”

Section: Introductionmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

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“…BPA intake is higher and more dangerous in infants and children, and it can lead to the onset of several diseases, such as cancer, endometriosis, birth defects, and developmental and neuronal disorders (Rochester 2013, Delclos et al 2014. BPA intake has also been associated with obesity and metabolic disorders (Rochester 2013, Lakind et al 2014, specifically in children (Trasande et al 2012, Nicolucci et al 2013.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders

Menale¹,

Piccolo²,

Cirillo³

et al. 2015

Journal of Molecular Endocrinology

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Bisphenol A (BPA) is a xenobiotic endocrine-disrupting chemical. In vitro and in vivo studies have indicated that BPA alters endocrine-metabolic pathways in adipose tissue, which increases the risk of metabolic disorders and obesity. BPA can affect adipose tissue and increase fat cell numbers or sizes by regulating the expression of the genes that are directly involved in metabolic homeostasis and obesity. Several studies performed in animal models have accounted for an obesogen role of BPA, but its effects on human adipocytesespecially in children -have been poorly investigated. The aim of this study is to understand the molecular mechanisms by which environmentally relevant doses of BPA can interfere with the canonical endocrine function that regulates metabolism in mature human adipocytes from prepubertal, non-obese children. BPA can act as an estrogen agonist or antagonist depending on the physiological context. To identify the molecular signatures associated with metabolism, transcriptional modifications of mature adipocytes from prepubertal children exposed to estrogen were evaluated by means of microarray analysis. The analysis of deregulated genes associated with metabolic disorders allowed us to identify a small group of genes that are expressed in an opposite manner from that of adipocytes treated with BPA. In particular, we found that BPA increases the expression of pro-inflammatory cytokines and the expression of FABP4 and CD36, two genes involved in lipid metabolism. In addition, BPA decreases the expression of PCSK1, a gene involved in insulin production. These results indicate that exposure to BPA may be an important risk factor for developing metabolic disorders that are involved in childhood metabolism dysregulation.

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Bisphenol A and indicators of obesity, glucose metabolism/type 2 diabetes and cardiovascular disease: A systematic review of epidemiologic research

Cited by 131 publications

References 112 publications

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Systematic review of the literature on triclosan and health outcomes in humans

Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders

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