Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster

Weiner, A.K.; Ramírez, A.A.; Zintel, T.; Rose, R. Wesley; Wolff, Edward F.; Parker, Annemarie; Bennett, Keiryn L.; Johndreau, K.; Rachfalski, C.; Zhou, Jingzhe; Smith, Sheryl T.

doi:10.1016/j.ecoenv.2013.12.008

Cited by 21 publications

(7 citation statements)

References 41 publications

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“…The first one involved in the operation of nuclear receptor steroid hormone pathway is recognized as the targets of EDCs in vertebrates (Maglich et al 2001). Bisphenol A (BPA), similar with EP, has estrogen effect and can affect the development and growth of Drosophila by interfering with the endocrine signals and estrogen receptor gene expression in D. melanogaster (Weiner et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling

Xue

Zhao

Qin

et al. 2017

Journal of Insect Science

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Ethylparaben (EP) has been shown to have estrogenic effects and can affect the normal development, longevity, and reproductive system of some animals. In this study, we investigated the effects of EP in male Drosophila melanogaster using transcriptome analysis or digital gene expression profiling. We then screened differentially expressed genes (DEGs) between the two groups (EP-treated and control group) of Drosophila, and performed clustering analysis, gene ontology (GO) function annotation, kyoto encyclopedia of gene and genomes metabolic pathway analysis. We found that EP enriched GO in three processes: cellular component, molecular function, and biological process. Consequently, we detected 13,959 genes and among them, 18 genes were identified to be significantly expressed between the EP-treated and control samples. Of these, seven genes were down-regulated, and eleven genes were up-regulated in EP-treated samples. Furthermore, four DEGs including two down-regulated genes (CG9465, CG9468) and two up-regulated genes (TotA, Sqz) were verified by real-time quantitative PCR. This study revealed the impact of EP on gene expression in fruit fly and provided new insight into the mechanisms of this response, which is helpful for understanding EP toxicity to humans.

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Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling

Xue

Zhao

Qin

et al. 2017

Journal of Insect Science

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“…This could be mediated be through an alteration in food intake since Drosophila larvae will alter their food intake in response to a variety of toxins in their environment. (Mueller and Barter, 2015; Perkhulyn et al, 2015; Weiner et al, 2014). It is also possible that the gut microbiota is being affected (Broderick and Lemaitre, 2012; Han et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the acceleration of development time and the change in body size that we observed may be due to atrazine acting as an endocrine disruption chemical (EDC) and affecting some component of the endocrine system such as the insulin signaling pathway. Other chemicals that have been classified as EDCs, such as bisphenol A (BPA), alter growth and development time in Drosophila and mice (Nikaido et al, 2004; Weiner et al, 2014). Clearly additional work, such as tighter time point monitoring and a better understanding of how atrazine is metabolized during development, will be required to understand the mechanisms underlying the observed effects on development rate and body size.…”

Section: Discussionmentioning

confidence: 99%

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

Marcus

Fiumera

2016

Journal of Insect Physiology

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Atrazine is the one of the most widely used herbicides in the United States and non-target organisms may encounter it in the environment. Atrazine is known to affect male reproduction in both vertebrates and invertebrates but less is known about its effects on other fitness traits. Here we assessed the effects of five different chronic exposure levels on a variety of fitness traits in Drosophila melanogaster. We measured male and female longevity, development time, proportion pupated, proportion emerged, body size, female mating rate, fertility and fecundity. Atrazine exposure decreased the proportion pupated, the proportion emerged and adult survival. Development time was also affected by atrazine and exposed flies pupated and emerged earlier than controls. Although development time was accelerated, body size was actually larger in some of the exposures. Atrazine exposure had no effect on female mating rate and the effects on female fertility and fecundity were only observed in one of the two independent experimental blocks. Many of the traits showed non-monotonic dose response curves, where the intermediate concentrations showed the largest effects. Overall this study shows that atrazine influences a variety of life history traits in the model genetic system, D. melanogaster, and future studies should aim to identify the molecular mechanisms of toxicity.

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“…In conclusion, it is well‐known that anthropogenic effects on ecosystems, such as contamination of water with toxic chemicals, such as EDs, have an effect on the fitness of individuals (Anway & Skinner, ; Colborn et al., ; Depledge & Billinghurst, ; Weiner et al., ). Despite this, the present study did not find a significant effect of EDs (i.e., BPA and NP) on the developmental time or fertility of two generations of D. melanogaster .…”

Section: Discussionmentioning

confidence: 92%

The multigenerational effects of water contamination and endocrine disrupting chemicals on the fitness of Drosophila melanogaster

Quesada-Calderón

Bacigalupe

Toro-Vélez

et al. 2017

Ecology and Evolution

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Water pollution due to human activities produces sedimentation, excessive nutrients, and toxic chemicals, and this, in turn, has an effect on the normal endocrine functioning of living beings. Overall, water pollution may affect some components of the fitness of organisms (e.g., developmental time and fertility). Some toxic compounds found in polluted waters are known as endocrine disruptors (ED), and among these are nonhalogenated phenolic chemicals such as bisphenol A and nonylphenol. To evaluate the effect of nonhalogenated phenolic chemicals on the endocrine system, we subjected two generations (F0 and F1) of Drosophila melanogaster to different concentrations of ED. Specifically, treatments involved wastewater, which had the highest level of ED (bisphenol A and nonylphenol) and treated wastewater from a constructed Heliconia psittacorum wetland with horizontal subsurface water flow (He); the treated wastewater was the treatment with the lowest level of ED. We evaluated the development time from egg to pupa and from pupa to adult as well as fertility. The results show that for individuals exposed to treated wastewater, the developmental time from egg to pupae was shorter in individuals of the F1 generation than in the F0 generation. Additionally, the time from pupae to adult was longer for flies growing in the H. psittacorum treated wastewater. Furthermore, fertility was lower in the F1 generation than in the F0 generation. Although different concentrations of bisphenol A and nonylphenol had no significant effect on the components of fitness of D. melanogaster (developmental time and fertility), there was a trend across generations, likely as a result of selection imposed on the flies. It is possible that the flies developed different strategies to avoid the effects of the various environmental stressors.

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Bisphenol A affects larval growth and advances the onset of metamorphosis in Drosophila melanogaster

Cited by 21 publications

References 41 publications

Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling

Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

The multigenerational effects of water contamination and endocrine disrupting chemicals on the fitness of Drosophila melanogaster

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