Bisphenol A affects germination and tube growth in Picea meyeri pollen through modulating Ca2+ flux and disturbing actin-dependent vesicular trafficking during cell wall construction

Chang, Tongjie; Fan, Chengyu; Man, Yi; Jun-hui, Zhou; Jing, Yanping

doi:10.1016/j.plaphy.2015.06.010

Cited by 16 publications

(3 citation statements)

References 39 publications

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“…It was also reported that approximately 50-100 ppm BPA disrupted microtubule arrays, thereby inhibiting cell division in pea (Pisum sativum L.), the gymnosperm Abies cephalonica, Triticum turgidum (durum wheat) and Allium cepa (onion) (Adamakis et al, 2019(Adamakis et al, , 2016(Adamakis et al, , 2013. In addition, 5-10 ppm BPA inhibited pollen tube growth by decreasing the deposition of cell wall components through disrupting Ca 2+ gradients and actin filaments in Picea meyeri (Chang et al, 2015). In mung bean (Vigna radiata), BPA treatment caused root and shoot growth retardation at the concentration of 750 ppm and 1000 ppm in soil, respectively (Kim et al, 2018a).…”

Section: Introductionmentioning

confidence: 98%

The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

Bahmani

Kim

Modareszadeh

et al. 2020

Environmental Pollution

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Bisphenol A (BPA) is a harmful environmental contaminant acting as an endocrine disruptor in animals, but it also affects growth and development in plants. Here, we have elucidated the functional mechanism of root growth inhibition by BPA in Arabidopsis thaliana using mutants, reporter lines and a pharmacological approach. In response to 10 ppm BPA, fresh weight and main root length were reduced, while auxin levels increased. BPA inhibited root growth by reducing root cell length in the elongation zone by suppressing expansin expression and by decreasing the length of the meristem zone by repressing cell division. The inhibition of cell elongation and cell division was attributed to the enhanced accumulation/redistribution of auxin in the elongation zone and meristem zone in response to BPA. Correspondingly, the expressions of most auxin biosynthesis and transporter genes were enhanced in roots by BPA. Taken together, it is assumed that the endocrine disruptor BPA inhibits primary root growth by inhibiting cell elongation and division through auxin accumulation/redistribution in Arabidopsis. This study will contribute to understanding how BPA affects growth and development in plants.

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Section: Introductionmentioning

confidence: 98%

The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

Bahmani

Kim

Modareszadeh

et al. 2020

Environmental Pollution

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“…The BPA is a ubiquitous environmental pollutant that affects pollen tube Ca (2 + ) flux in P. meyeri , resulting in troublesome AF association, subsequent to irregular actin-dependent vesicle trafficking. Furthermore, it disrupts the deposition of cell wall components, and these discoveries offer a fresh comprehension of the mechanism behind the toxicity of BPA in the formation of pollen tube tips [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

Synergism of vesicle trafficking and cytoskeleton during regulation of plant growth and development: A mechanistic outlook

Khoso,

Zhang,

Khoso

et al. 2023

Heliyon

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“…Bisphenol A (BPA) is a kind of phenolic compound widely used in the production of polycarbonate, polystyrene resin, epoxy resins, electronic equipment and food and beverage packaging (Chang et al, 2015;Staples et al, 1998). In 2015, the global consumption of BPA reached 7.7 million metric tons.…”

Section: Introductionmentioning

confidence: 99%

Involvement of NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis In BPA-Induced Apoptosis of Neuroblastoma Cells

Wang

Huang

et al. 2021

Preprint

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BackgroundBisphenol A (BPA) is an additive in polycarbonate and epoxy resin particles with endocrine disrupting effects. Previously it has been reported that BPA is neurotoxic via induction of cell apoptosis and inflammation, and our recent studies showed that even at nanomolar concentrations BPA accelerated the apoptosis and death of human neuroblastoma cells from both genders, whose mechanisms remain, however, unidentified.ResultsHuman neuroblastoma cell lines developed from male and female subjects, IMR-32 and SK-N-SH, respectively, were exposed to BPA at concentrations ranging from 1 nM to 100 μM, for 24 h, with or without epigallocatechin gallate (EGCG, 4 or 8 μM), Z-YVAD-FMK (1 or 10 μM, caspase-1 inhibitor), and ICI182.780 (100 nM or 3 μM, estrogen receptor inhibitor) as modulators. The results showed that BPA nonlinearly upregulated the levels of IL-18, ASC, GSDMD and NLRP3 mRNAs and that of NLRP3, caspase-1, GSDMD and IL-1β proteins in IMR-32 and SK-N-SH cells. Noticeably, the mRNA levels of caspase-1 and IL-1β were changed differently in the two cell lines: the level of caspase-1 mRNA was enhanced in IMR-32 cells but suppressed in SK-N-SH cells, and that of IL-1β was suppressed in IMR-32 cells but enhanced in SK-N-SH cells. The level of GSDMD expression in situ was along with the increase in the release of IL-1β, IL-18, caspase-1 and lactate dehydrogenase (LDH). Additionally, Z-YVAD-FMK, ICI182.780 and EGCG significantly reversed the changes of the above mRNAs/proteins induced by BPA. BPA significantly reduced the level of the reactive oxygen species and the rate of LDH leakage and apoptosis, while obviously increased the cell viability and the mitochondrial membrane potential. Meanwhile, Z-YVAD-FMK and ICI182.780 abruptly reduced the levels of Bak1, Bax, Bcl-2 and caspase-3 proteins induced by BPA. ConclusionAs mediated by the estrogen receptor, BPA may induce the pyroptosis of neuroblastoma cells through NLRP3/caspase-1/GSDMD signaling pathway, and caspase-1-dependent pyroptosis may be involved in BPA-induced apoptosis, which is alleviated by EGCG, an anti-oxidation agent.

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Bisphenol A affects germination and tube growth in Picea meyeri pollen through modulating Ca2+ flux and disturbing actin-dependent vesicular trafficking during cell wall construction

Cited by 16 publications

References 39 publications

The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

The mechanism of root growth inhibition by the endocrine disruptor bisphenol A (BPA)

Synergism of vesicle trafficking and cytoskeleton during regulation of plant growth and development: A mechanistic outlook

Involvement of NLRP3/Caspase-1/GSDMD-Dependent Pyroptosis In BPA-Induced Apoptosis of Neuroblastoma Cells

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