Bisphenol A affects axonal growth, musculature and motor behavior in developing zebrafish

Wang, Xuechun; Dong, Qian; Chen, Yuanhong; Jiang, Hong; Xiao, Qian; Wang, Yujiang; Li, Wenwen; Bai, Chenglian; Huang, Changjiang; Yang, Dongren

doi:10.1016/j.aquatox.2013.07.011

Cited by 56 publications

(44 citation statements)

References 43 publications

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“…An increasing number of studies pointed out the deleterious impact of BPA on zebrafish central and peripheral developmental processes. Alterations of heart morphology, skeletal muscles organizations have been described in early-life BPAtreated zebrafish [125][126][127][128]. A recent study showed that zebrafish embryos exposed to BPA accumulate lipids, suggesting a role of BPA in the onset of overweight and obesity [129].…”

Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 97%

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Pellegrini

Diotel

Vaillant-Capitaine

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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Estrogens are known as steroid hormones affecting the brain in many different ways and a wealth of data now document effects on neurogenesis. Estrogens are provided by the periphery but can also be locally produced within the brain itself due to local aromatization of circulating androgens. Adult neurogenesis is described in all vertebrate species examined so far, but comparative investigations have brought to light differences between vertebrate groups. In teleost fishes, the neurogenic activity is spectacular and adult stem cells maintain their mitogenic activity in many proliferative areas within the brain. Fish are also quite unique because brain aromatase expression is limited to radial glia cells, the progenitor cells of adult fish brain. The zebrafish has emerged as an interesting vertebrate model to elucidate the cellular and molecular mechanisms of adult neurogenesis, and notably its modulation by steroids. The main objective of this review is to summarize data related to the functional link between estrogens production in the brain and neurogenesis in fish. First, we will demonstrate that the brain of zebrafish is an endogenous source of steroids and is directly targeted by local and/or peripheral steroids. Then, we will present data demonstrating the progenitor nature of radial glial cells in the brain of adult fish. Next, we will emphasize the role of estrogens in constitutive neurogenesis and its potential contribution to the regenerative neurogenesis.Finally, the negative impacts on neurogenesis of synthetic hormones used in contraceptive pills production and released in the aquatic environment will be discussed.

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Section: Adverse Effects Of Endocrine Disruptors During Early Neurogementioning

confidence: 97%

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Pellegrini

Diotel

Vaillant-Capitaine

et al. 2016

The Journal of Steroid Biochemistry and Molecular Biology

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“…not high enough to disrupt the axonal growth of primary and secondary motor neurons in zebrafish (Wang et al, 2013), and E2 is associated with the defect of neurobehavioral development which may seriously affect the activity (Hamad et al, 2007). The decreased locomotor performances can increase lethargy in the shoal of fish.…”

Section: Discussionmentioning

confidence: 97%

“…Saili et al (2012) found that BPA led to hyperactivity of larval fish and learning deficits in adult zebrafish. Wang et al (2013) only reported that BPA exposure altered spontaneous movement, decreased touch response and swimming speed in response to light stimulation in larval zebrafish by inducing axial muscle damage. However, numerous behavioral tasks by chronic BPA exposure are not well known.…”

Section: Introductionmentioning

confidence: 97%

Chronic bisphenol A exposure alters behaviors of zebrafish (Danio rerio)

Wang

Xiong

et al. 2015

Environmental Pollution

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“…Normally, type III collagen fibres show a striated morphology, but when they are formed inside fibrous tissues they are abnormally synthesized and some atypical thickenings, known as microkeloids, are produced, and they turn into rupture-sensitive areas (aBate et al, 2013;rOCheSter, 2013). at present, there are no references regarding direct BPa action in the tendon, and very few related to its action in the muscle (MOrtaVazI et al, 2013;WaNg et al, 2013;GIMéNez et al, 2016). However, in this regard, the modifications observed by gIMéNez et al (2016) could be compatible with those caused by exogenous treatments with hormonal compounds, coinciding at this point with previous studies, in which an increase in abnormal collagen fibre was reported after anabolic steroid administration (JEFFREY and JEFFREY, 1991).…”

Section: Resultsmentioning

confidence: 99%

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

Bellido¹,

Córdoba²,

Abellán³

et al. 2018

Vet. arhiv

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Bisphenol-a is a well-known compound with estrogenic activity, which is produced in tons world-wide and is abundantly used as a component of food containers, so that it frequently migrates into food and appears as an environmental pollutant. this study aimed to assess the effects of Bisphenol-a at the tendon level, possible reversal after it is withdrawn from exposure, and its recovery after the application of plate-enriched plasma. For this purpose, 16 animals were randomly distributed to one of the experiment groups: control group, group treated with BPa (for 4 months), group BPa-withdrawal (treated for 2 months with BPa and two months without BPa), and platelet-rich plasma (PrP) group (treated for 2 months with BPa, when it was withdrawn and the PrP treatment began for 2 months). at the end of the treatments biopsy of the achilles tendon was carried out. the samples were analysed by optical and electron microscopy and immunohistochemistry. histopathology was a fundamental tool in the evaluation of the tendon after exposure to Bisphenol-a. Our results showed how, after withdrawal of BPa, there was recovery from the lesions caused, with diminution in the type III collagen fibres along with tendon vascularization processes; in the group to which PRP was applied, almost complete recovery from the lesions caused occurred, and the immunocytochemistry test was negative for the type III collagen fibres. Our results indicate that tendons were affected after BPA exposure, but that the lesions were partially reversible after BPa was withdrawn. PrP application enabled tendon lesions to recuperate and all signs of inflammation disappeared.

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Bisphenol A affects axonal growth, musculature and motor behavior in developing zebrafish

Cited by 56 publications

References 43 publications

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

Chronic bisphenol A exposure alters behaviors of zebrafish (Danio rerio)

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

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