Bisphenol A: Acute Aquatic Toxicity

Alexander, H. C.; Dill, D. C.; Smith, Ladd W.; Guiney, Patrick D.; Dorn, Philip B.

doi:10.1897/1552-8618(1988)7[19:baaat]2.0.co;2

Cited by 19 publications

(28 citation statements)

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“…Sohoni et al [18] exposed fathead minnows to BPA for 164 d and observed an inhibition of egg production in the 1,280‐μg/L group. The 96‐h LC50 of BPA was 4,600 μg/L in fathead minnows [24], about threefold higher than their LOEC for impaired reproduction. We speculate that the apparent differences between the reproductive effects of BPA in medaka and those in fathead minnows may be due to differences between the organisms and test durations used.…”

Section: Discussionmentioning

confidence: 99%

Effects of bisphenol a on the reproduction of Japanese medaka (Oryzias latipes)

Kang

Yokota

Oshima³

et al. 2002

Enviro Toxic and Chemistry

142

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We elucidated the effects of bisphenol A (BPA) on the reproductive capacity (fecundity and fertility) and estrogenic response of adult Japanese medaka (Oryzias latipes) and studied the transgenerational effects (F, generation growth and sex) of this agent on the F1 offspring. Eight mating pairs of medaka were exposed to BPA for three weeks at a measured concentration of 837, 1,720, or 3,120 microg/L. Throughout the exposure period, we observed no reduction of fecundity and fertility in any treatment group and no reduction in survival and growth or any imbalance of the sex ratio of the offspring. However, histologic examination revealed testis-ova in 13% of the males in the 837-microg/L treatment group, 86% of those in the 1,720-microg/L group, and 50% of those that received 3,120 microg BPA/L. In addition, concentrations of hepatic vitellogenin were increased significantly in males treated with BPA at 3,120 microg/L (p = 0.0148). These results suggest that BPA is a weakly estrogenic compound that has the potential to alter sexual development and induce vitellogenin in male medaka but that has no adverse effect on reproductive success.

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Section: Discussionmentioning

confidence: 99%

Effects of bisphenol a on the reproduction of Japanese medaka (Oryzias latipes)

Kang

Yokota

Oshima³

et al. 2002

Enviro Toxic and Chemistry

142

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“…The lowest concentration (0.2 g/L) was spiked purely with 14 bisphenol A and the other concentrations with both labeled and nonlabeled bisphenol A in the following mixing ratios: Concentration in exposure water, 1.5 g/L (33% of 14 C-labeled bisphenol A from total amount of bisphenol A), 10.5 g/L (4.8%), and 100.5 g/L (0.50%). The exposure waters were aerated for 24 to 48 h and, thereafter, spiked with 14 Clabeled bisphenol A ([propyl-2-14 C]; specific activity, 2,074 MBq/mmol; radiochemical purity, 99.9%; Moravek Biochemicals, Brea, CA, USA) and/or with nonlabeled bisphenol A (purity, Ͼ99%; Sigma-Aldrich, Gillingham, UK).…”

Section: Water and Chemicalsmentioning

confidence: 99%

Environmental temperature changes uptake rate and bioconcentration factors of bisphenol A in tadpoles of Rana Temporaria

Honkanen

Kukkonen

2006

Enviro Toxic and Chemistry

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Toxicokinetics of radiolabeled (14C) bisphenol A was studied in the common frog (Rana temporaria) at two experimental temperatures (7 and 19 degrees C). The growth rate of the tadpoles during the 96-h experiment was very slow at 7 degrees C, but the weight of tadpoles almost tripled at 19 degrees C. At all tested exposure concentrations (0.2, 1.5, 10, and 100 microg/L), conditional uptake rate constants (ku) were 69 to 82%, and elimination rates (ke) 79 to 90% lower, at 7 degrees C than at 19 degrees C. On the contrary, bioconcentration factors (BCFs) were higher at 7 degrees C than at 19 degrees C. Total accumulated bisphenol A per individual was higher at 19 degrees C, which is in agreement with higher k, at 19 degrees C. Exposure concentrations did not have any constant effect on BCFs at the two temperatures. The results of the current experiment suggest that higher temperature increases uptake and total amount of chemical in frog tadpoles but does not necessarily lead to higher BCFs. High temperature may have increased the growth rate more than the uptake rate, resulting in a net dilution of bisphenol A in tadpole tissues. The observed difference in BCFs also could be a result of temperature-induced changes in allometric relationships (increased surface area to volume ratio) and/or more effective elimination in more developed tadpoles at high temperature.

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“…Although BPA was one of the toxicity causative chemicals in the landfill leachate, BPA toxicity was not determined by the SPE manipulation tests of treatability-based TIE, because toxicity of ammonia was relatively large so that the toxicity of BPA was shadowed. According to the previous studies on the toxicity of BPA, the acute toxicity data showed that BPA was moderately toxic to the invertebrates tests [14]. Shoji et al tried to find toxicity-controlling chemicals in waste landfill leachate [7] and waste samples such as various sludges [15].…”

Section: Resultsmentioning

confidence: 99%

Analysis of Ammonia Toxicity in Landfill Leachates

et al. 2011

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Toxicity identification evaluation (TIE) phase I manipulations and toxicity test with D. magna were conducted on leachates from an industrial waste landfill site in Japan. Physicochemical analysis detected heavy metals at concentrations insufficient to account for the observed acute toxicity. The graduated pH and aeration manipulations identified the prominent toxicity of ammonia. Based on joint toxicity with additive effects of unionized ammonia and ammonium ions, the unionized ammonia toxicity (LC50,NH3(aq)) was calculated as 3.3 ppm, and the toxicity of ammonium ions (LC50,NH4+) was calculated as 222 ppm. Then, the contribution of ammonia toxicity in the landfill leachate toxicity was calculated as 58.7 vol% of the total toxicity in the landfill leachate. Other specific toxicants masked by ammonia's toxicity were detected. Contribution rate of the toxicants other than by ammonia was 41.3 vol% of the total toxicity of the landfill leachate.

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Bisphenol A: Acute Aquatic Toxicity

Cited by 19 publications

References 0 publications

Effects of bisphenol a on the reproduction of Japanese medaka (Oryzias latipes)

Effects of bisphenol a on the reproduction of Japanese medaka (Oryzias latipes)

Environmental temperature changes uptake rate and bioconcentration factors of bisphenol A in tadpoles of Rana Temporaria

Analysis of Ammonia Toxicity in Landfill Leachates

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