Bispectral Index Monitoring Tailors Clinical Anesthetic Delivery and Reduces Anesthetic Drug Consumption

Clinical effectiveness and cost-effectiveness of depth of anaesthesia monitoring (E-Entropy, Bispectral Index and Narcotrend): a systematic review and economic evaluation

“…45,46,[51][52][53] The remaining six studies were conducted in adults, 40,44,[47][48][49]62 with mean ages ranging across the studies from 43 to 64 years. One study was conducted to investigate POCD in an elderly population, defined as > 60 years (no further age information given) (conference abstract).…”

“…> 60%) in three studies. 46,48,51 One study did not report the sex of the included patients. 47 All but one of the studies reported patients' weight.…”

“…44 The countries in which the trials were conducted included the USA, 45,49,52,53 USA/Canada, 44 China, 40,47,51 Germany, 62 Egypt 48 and India. 46 In the Cochrane BIS review 34 the majority of studies were conducted in Europe or the USA.…”

“…There were seven (46%) 45,46,48,52,53,59,62 that included fewer than 100 patients and five (33%) 48,51,61,63,64 that had between 101 and 200 patients. One trial included 921 patients, 47 another included 5309 40 and another, the largest, included 6041 patients.…”

“…Six (55%) 40,44,46,48,49,62 of the 11 BIS trials reported patient attrition. The attrition rate varied from 1.5% 40 to 15% 49 of the total number of patients enrolled.…”