“…In propofol-based anaesthesia, there is a dose-dependent decrease in the BIS. The administration of low doses of propofol increases the amplitude and the EEG alpha waves rhythm, followed by a shift to EEG gamma and theta frequency and when higher doses are given, there is burst suppression and a decrease of the amplitude of the EEG (Yate et al 1986;Hazeaux et al 1987;Billard et al 1997;Glass et al 1997;Liu et al 1997;Struys et al 1998;Bousoula et al 2003;Bruhn et al 2003;Ellerkmann et al 2006).…”