Bismuth Oxyiodide Nanoflakes Showed Toxicity Against the Malaria Vector Anopheles stephensi and In Vivo Antiplasmodial Activity

Murugan, Kadarkarai; Madhavan, Jagannathan; Samidoss, Christina Mary; Panneerselvam, Chellasamy; Aziz, Al Thabiani; Arumugam, Malathi; Rajasekar, Aruliah; Amuthavalli, Pandiyan; Kumar, Suresh; Alarfaj, Abdullah A.; Higuchi, Akon; Benelli, Giovanni

doi:10.1007/s10876-018-1332-3

Cited by 6 publications

(2 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 ). After 4 days of 4,7-dichloroquinoline treated groups exhibited the percentage of parasitemia 10.6 ± 0.8% at 300 mg/kg/day than that of the control drug chloroquine (CQ) 1.0 ± 0.0% 37 , 66 . Tang et al 67 showed antimalarial activities against the P. falciparum strain K173 with EC 50 values ranging from 0.38 to 0.43 mg/kg.…”

Section: Resultsmentioning

confidence: 95%

“…The mosquitoes A. aegypti and A. stephensi were cultured and maintained following Murugan et al 37 . For toxicology studies, 25 individuals of both A. stephensi and A. aegypti larva (1st, 2nd, 3rd, and 4th) and pupae were placed for a 24 h treatment in a tank filled with 500 mL of distilled water at concentrations of 4,7-dichloroquinoline (2, 4, 6, 8 and 10 ppm) 38 .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases

Murugan

Panneerselvam

Subramaniam

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti. In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC50 values of 6.7 nM (CQ-s) and 8.5 nM (CQ-r). Chloroquine IC50 values, as control, were 23 nM (CQ-s), and 27.5 nM (CQ-r). In vivo antiplasmodial studies with P. falciparum infected mice showed an effect of 4,7-dichloroquinoline compared to chloroquine. The quinoline compound showed significant activity against the viral pathogen serotype 2 (DENV-2). In vitro conditions and the purified quinoline exhibited insignificant toxicity on the host system up to 100 µM/mL. Overall, 4,7-dichloroquinoline could provide a good anti-vectorial and anti-malarial agent.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%