Bismuth-nanoparticles decorated multi-wall-carbon-nanotubes cast-coated on carbon paste electrode; an electrochemical sensor for sensitive determination of Gallic Acid at neutral pH

Madhusudhana,; Manasa, G.; Bhakta, Arvind K.; Mekhalif, Zineb; Mascarenhas, Ronald J.

doi:10.1016/j.mset.2019.10.001

Cited by 28 publications

(10 citation statements)

References 43 publications

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“…The linear relationship was noticed with the regression equation as E p = 1.15–0.0578 pH; R 2 = 0.97. The experimental slope value is closer to the theoretical Nernst value (0.059 V/pH), thus confirming the participation of two numbers of electrons in the hydronium-ion-coupled reaction mechanism [ 38 ]. Furthermore, the number of hydronium ions involved in the electrode process was determined by using the Nernst equation (Equation (2)).…”

Section: Resultssupporting

confidence: 68%

Direct and Sensitive Electrochemical Evaluation of Pramipexole Using Graphitic Carbon Nitride (gCN) Sensor

Shanbhag

Malode

et al. 2022

Biosensors

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Pramipexole (PMXL) belongs to the benzothiazole class of aromatic compounds and is used in treating Parkinson’s disease; however, overdosage leads to some abnormal effects that could trigger severe side effects. Therefore, it demands a sensitive analytical tool for trace level detection. In this work, we successfully developed an electrochemical sensor for the trace level detection of PMXL, using the voltammetric method. For the analysis, graphitic carbon nitride (gCN) was opted and synthesized by using a high-temperature thermal condensation method. The synthesized nanoparticles were employed for surface characterization, using transmission electron microscopy (TEM), X-ray diffraction (XRD), and atomic force microscopy (AFM) techniques. The electrochemical characterization of the material was evaluated by using the electrochemical impedance spectroscopy (EIS) technique to evaluate the solution–electrode interface property. The cyclic voltammetry (CV) behavior of PMXL displayed an anodic peak in the forward scan, indicating that PMXL underwent electrooxidation, and an enhanced detection peak with lower detection potential was achieved for gCN-modified carbon paste electrode (gCN·CPE). The influence of different parameters on the electrochemical behavior was analyzed, revealing the diffusion governing the electrode process with an equal number of hydronium ions and electron involvement. For the fabricated gCN·CPE, good linearity range was noticed from 0.05 to 500 µM, and a lower detection limit (LD) of 0.012 µM was achieved for the selected concentration range (0.5 to 30 µM). Selectivity of the electrode in PMXL detection was investigated by conducting an interference study, while the tablet sample analysis demonstrates the sensitive and real-time application of the electrode. The good recovery values for the analysis illustrate the efficiency of the electrode for PMXL analysis.

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Section: Resultssupporting

confidence: 68%

Direct and Sensitive Electrochemical Evaluation of Pramipexole Using Graphitic Carbon Nitride (gCN) Sensor

Shanbhag

Malode

et al. 2022

Biosensors

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“…The amperometric response observed remained constant throughout the experiment. The surface of the electrodes did not undergo any fouling; hence, this attests to the proposed sensor’s stability [ 43 ]. The stability was again analyzed using the above concentrations of the analytes using DPV on the first day using two modified electrodes, which was then stored for 10 days at room temperature in the laboratory.…”

Section: Resultsmentioning

confidence: 82%

“…The results suggest that the nanoparticles’ presence can facilitate electron transfer between the electrode surface and the redox solution, thereby increasing electro-conductibility. Hence, Fe 3 O 4 nanoparticle was very efficient for developing an electrochemical sensor for the analysis of phenolic compounds [ 23 , 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Sensor for Determination of Various Phenolic Compounds in Wine Samples Using Fe3O4 Nanoparticles Modified Carbon Paste Electrode

et al. 2021

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Phenolic compounds contain classes of flavonoids and non-flavonoids, which occur naturally as secondary metabolites in plants. These compounds, when consumed in food substances, improve human health because of their antioxidant properties against oxidative damage diseases. In this study, an electrochemical sensor was developed using a carbon paste electrode (CPE) modified with Fe3O4 nanoparticles (MCPE) for the electrosensitive determination of sinapic acid, syringic acid, and rutin. The characterization techniques adapted for CPE, MCPE electrodes, and the solution interface were cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Scan rate and pH were the parameters subjected to optimization studies for the determination of phenolic compounds. The incorporation of Fe3O4 nanoparticles to the CPE as a sensor showed excellent sensitivity, selectivity, repeatability, reproducibility, stability, and low preparation cost. The limits of detection (LOD) obtained were 2.2 × 10−7 M for sinapic acid, 2.6 × 10−7 M for syringic acid, and 0.8 × 10−7 M for rutin, respectively. The fabricated electrochemical sensor was applied to determine phenolic compounds in real samples of red and white wine.

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“…Over the past few years, in efforts to achieve sensitive OC biomarker detection, efforts in the direction of simple, inexpensive, and accurate point-of-care (POC) assays, especially electrochemical (EC) sensors and biosensors, have attracted considerable attention worldwide, , as comparatively traditional bioassays are expensive and laborious, requiring specialized technicians. The EC sensors are easy to operate and produce rapid results; they are affordable and portable. − Also, they require multiple-step processes and additional reading equipment, whereas biosensors incorporate the sensing element and the signal reader together in one device. The operational principle behind the EC sensor is that the detection layer can be developed on the EC transducer, and when the recognition event occurs between the target analyte and the detection layer, the environment around the transducer is altered, thereby allowing the measurement. − Depending on the nature of EC changes detected during the course of the recognition reaction, EC sensors or biosensors are categorized into five subclasses, viz., (i) potentiometry, (ii) conductometry, (iii) voltammetry, (iv) amperometry, and (v) impedance.…”

Section: Ec Biosensing Of Oncomarkersmentioning

confidence: 99%

Biomarkers for Early Diagnosis of Ovarian Carcinoma

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Biomater. Sci. Eng.

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The leading cause of gynecological cancer-related morbidity and mortality is ovarian cancer (OC), which is dubbed a silent killer. Currently, OC is a target of intense biomarker research, because it is often not discovered until the disease is advanced. The goal of OC research is to develop effective tests using biomarkers that can detect the disease at the earliest stages, which would eventually decrease the mortality, thereby preventing recurrence. Therefore, there is a pressing need to revisit the existing biomarkers to recognize the potential biomarkers that can lead to efficient predictors for the OC diagnosis. This Perspective covers an update on the currently available biomarkers used in the triaging of OC to gain certain insights into the potential role of these biomarkers and their estimation that are crucial to the understanding of neoplasm progression, diagnostics, and therapy.

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Bismuth-nanoparticles decorated multi-wall-carbon-nanotubes cast-coated on carbon paste electrode; an electrochemical sensor for sensitive determination of Gallic Acid at neutral pH

Cited by 28 publications

References 43 publications

Direct and Sensitive Electrochemical Evaluation of Pramipexole Using Graphitic Carbon Nitride (gCN) Sensor

Direct and Sensitive Electrochemical Evaluation of Pramipexole Using Graphitic Carbon Nitride (gCN) Sensor

Electrochemical Sensor for Determination of Various Phenolic Compounds in Wine Samples Using Fe3O4 Nanoparticles Modified Carbon Paste Electrode

Biomarkers for Early Diagnosis of Ovarian Carcinoma

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