Bismuth(III) complexes with 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones: Antimicrobial and cytotoxic activities and effects on the clonogenic survival of human solid tumor cells

Abstract

Complexes [Bi(2AcPh)Cl2]·0.5H2O (1), [Bi(2AcpClPh)Cl2] (2), [Bi(2AcpNO2Ph)Cl2] (3), [Bi(2AcpOHPh)Cl2]·2H2O (4), [Bi(H2BzPh)Cl3]·2H2O (5), [Bi(H2BzpClPh)Cl3] (6), [Bi(2BzpNO2Ph)Cl2]·2H2O (7) and [Bi(H2BzpOHPh)Cl3]·2H2O (8) were obtained with 2-acetylpyridine phenylhydrazone (H2AcPh), its -para-chloro-phenyl- (H2AcpClPh), -para-nitro-phenyl (H2AcpNO2Ph) and -para-hydroxy-phenyl (H2AcpOHPh) derivatives, as well as with the 2-benzoylpyridine phenylhydrazone analogues (H2BzPh, H2BzpClPh, H2BzpNO2Ph, H2BzpOHPh). Upon coordination to bismuth(III) antibacterial activity against Gram-positive and Gram-negative bacterial strains significantly improved except for complex (4). The cytotoxic effects of the compounds under study were evaluated on HL-60, Jurkat and THP-1 leukemia, and on MCF-7 and HCT-116 solid tumor cells, as well as on non-malignant Vero cells. In general, 2-acetylpyridine-derived hydrazones proved to be more potent and more selective as cytotoxic agents than the corresponding 2-benzoylpyridine-derived counterparts. Exposure of HCT-116 cells to H2AcpClPh, H2AcpNO2Ph and complex (3) led to 99% decrease of the clonogenic survival. The IC50 values of these compounds were three-fold smaller when cells were cultured in soft-agar (3D) than when cells were cultured in monolayer (2D), suggesting that they constitute interesting scaffolds, which should be considered in further studies aiming to develop new drug candidates for the treatment of colon cancer.

[Ag(L)NO3] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules

“… 4 , 16 The signals of all carbons are also duplicated in the 13 C NMR spectra of the hydrazones, according to the presence of the Z and E isomeric forms in solution. 3 …”

Nanoparticles for treatment of bovine Staphylococcus aureus mastitis

“…Metal nanoparticles are a broad field of attention to prevent MRSA infections development (Hibbitts & O'Leary, 2018). The common metals nanoparticles which have a robust antimicrobial feature, representing an ability to eliminate MRSA biofilms (Mocan et al, 2014;Vijayakumar et al, 2015;Ferreira et al, 2016;Alhadrami & Al-Hazmi, 2017;Aswathanarayan & Vittal, 2017;Guo et al, 2017;Hsueh et al, 2017;Mekkawy et al, 2017), as explained in (Table 3).…”

“…" Radiation-stimulated formation of free radical and damage of DNA" (Ferreira et al, 2016) Note. Ag NPs: Silver Nanoparticles; ZnO: Zinc Oxide; Cu/CuO: Copper/Copper Oxide; TiO 2 : Titanium Oxide; MgX 2 : Magnesium with X 2 referring to a bonded halide; Au: Gold; Bi: Bismuth.…”

Preparation, Characterization, and Catalytic Property of a Cu(II) Complex with 2-Carboxybenzaldehyde-p-Toluenesulfonyl Hydrazone Ligand

“…For example, they have been widely exploited for luminescence [1][2][3][4], antitumor [5][6][7][8], antibacterial [9][10][11][12], gas storage [13], as well as magnetic [14][15][16][17]. Meanwhile, metal complex materials have also been attracted interests due to their excellent catalytic activities for many organic reactions [18][19][20][21][22].…”