Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy

Sharma, Bhavya; Bugga, Pradeep; Madison, Lindsey R.; Henry, Anne Isabelle; Blaber, Martin G.; Greeneltch, Nathan G.; Chiang, Naihao; Mrksich, Milan; Schatz, George C.; Duyne, Richard P. Van

doi:10.1021/jacs.6b07331

Cited by 107 publications

(73 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[13] Thei ncreased nucleation sites can be achieved owing to the uniform electric field and charge distribution through the surface modification of PA M. Therefore,z inc tends to grow uniformly and eventually forms as mooth plating surface.F rom the Raman spectra (Figure 1b), the characteristic peaks of pristine PA Misobserved at 839 cm À1 (CÀCs ide-chain vibration), 1106 cm À1 (CÀC skeletal stretching), 1319 cm À1 (C À Hbending), 1441 cm À1 (C À Ns tretching), 1610 cm À1 (N À Hb ending), 1665 cm À1 (C = O stretching), and 2925 cm À1 (C À Hs tretching), respectively, indicating that PA Mi salong-chain polymer with abundant acyl groups. [15] Thee lectrolytes with different concentrations of PA M were investigated to optimize the amount of PA M. [16] In the comparison of the electrochemical windows (Figure 1f), the zinc plating potential is decreased from À0.103 to À0.041 Vw ith the added amount of PA Mincreasing,which can be attributed to the activation of PA Mi nt he zinc plating process.T he oxygen evolution potential increases about 0.1 Vafter the addition of PA M. This widened electrochemical window is beneficial to expanding the available voltage range of the batteries.T he chemical stability of zinc was examined by immersing zinc foil in the electrolytes for 7days.The surface morphologies of the soaked zinc foils in the electrolytes with different PA Mc oncentrations are shown in Figure 1g-j. Thei ntensity changes of these peaks are clearly shown in the Supporting Information, Table S1, from which we can conclude that PA M is lied on the metal substrate by the absorption of acyl groups at side chains.O wing to the surface-enhanced Raman scattering,t he group absorbed on the metal surface generally exhibits the relatively strong intensity of Raman signal.…”

Section: Introductionmentioning

confidence: 99%

The Three‐Dimensional Dendrite‐Free Zinc Anode on a Copper Mesh with a Zinc‐Oriented Polyacrylamide Electrolyte Additive

et al. 2019

View full text Add to dashboard Cite

Rechargeable aqueous zinc-ion batteries have been considered as ap romising candidate for next-generation batteries.H owever,t he formation of zinc dendrites are the most severe problems limiting their practical applications.T od evelop stable zinc metal anodes,asynergistic method is presented that combines the Cu-Zn solid solution interface on ac opper mesh skeleton with good zinc affinity and ap olyacrylamide electrolyte additive to modify the zinc anode,whichcan greatly reduce the overpotential of the zinc nucleation and increase the stability of zinc deposition. The as-prepared zinc anodes show adendrite-free plating/stripping behavior over awide range of current densities.T he symmetric cell using this dendrite-free anode can be cycled for more than 280 hw ith av ery lowv oltage hysteresis (93.1 mV) at ad ischarged epth of 80 %. The high capacity retention and low polarization are also realized in Zn/MnO 2 full cells.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

show abstract

Section: Introductionmentioning

confidence: 99%

The Three‐Dimensional Dendrite‐Free Zinc Anode on a Copper Mesh with a Zinc‐Oriented Polyacrylamide Electrolyte Additive

et al. 2019

View full text Add to dashboard Cite

show abstract

“…SESORS-based measurements can now monitor glucose in vivo for more than than 17 days. More recently, the DT/MH system has been replaced with one based on a thiol-containing bis(boronic acid) receptor, which rapidly and preferentially binds glucose over other sugars 50 . The resulting Raman data could be interpreted using multivariate statistical analysis to distinguish normal, hypoglycemic and hyperglycemic responses.…”

Section: [H1] Key Advances In In Vivo Sensingmentioning

confidence: 99%

“…For example, the use of non-targeting and targeting probes allows specific and non-specific binding to be discerned during cancer detection, 49 and more sophisticated nanoprobes have improved glucose selectivity. 50 We are hopeful that the full benefits of SERS will be realised in the coming years, as the technique continues to be pushed further towards in vivo clinical use. Despite only 11 years having passed since the first in vivo study, many promising studies have already surfaced, including some in glucose sensing 29,48,51 and cancer diagnosis.…”

mentioning

confidence: 99%

Surface-enhanced Raman spectroscopy for in vivo biosensing

et al. 2017

View full text Add to dashboard Cite

| Surface enhanced Raman scattering (SERS) is of interest for biomedical analysis and imaging due to its sensitivity, specificity and multiplexing capabilities. The successful application of SERS for in vivo biosensing necessitates probes to be biocompatible and procedures to be minimally invasive, challenges that have respectively been met by the design of nanoprobes and instrumentation. This Review presents recent developments in these areas, describing case studies in which sensors have been implemented, as well as outlining shortcomings that have to be addressed before SERS sees clinical use.In 1928, C. V. Raman first reported the scattering phenomenon that now bears his name.1,2 Raman scattering has since become a powerful analytical technique, including for biomedical applications, 3 where label-free and objective tissue diagnostics 4-6 ex vivo and in vivo, as well as drug-cell interaction studies in vitro have been conducted. [7][8][9] The majority of incident photons experience elastic (Rayleigh) scattering, with only about 1 in 10 7 photons undergoing inelastic (Raman) scattering. 10 In 1974, Fleischmann and co-workers described a phenomenon that would later become known as surface enhanced Raman scattering (SERS) 11 . They observed a large enhancement in inelastic scattering from pyridine when the analyte was adsorbed onto a Ag electrode, an effect that had previously been mentioned by the team of A. J. McQuillan in 1973, 12 with Van Duyne later attributing the signal enhancement to the roughened metal surface via the physical phenomenon he coined SERS.13 Unlike conventional Raman spectroscopy, SERS analyses require samples to be labelled, a disadvantage offset by the large intensity enhancement that makes SERS an important analytical tool with high sensitivity and low detection limits.14,15 The exact mechanism of SERS is not fully understood but an electromagnetic enhancement factor plays the major role 16 , whereby free electrons in a metal nanoparticle (NP) encounter applied radiation whose electromagnetic field varies at a frequency matching the oscillation frequency of electrons in the NPs. Such plasmon resonance at the NP surface arises from an intense electric field, which intensifies Raman modes arising from molecules near or attached to the NP surface. The Raman signals can also be enhanced due to the formation of chargetransfer complexes between the roughened metal surface and molecules bound to it. We now leave our discussion of the SERS mechanism, but refer readers interested in these fundamental principles to some comprehensive articles on the subject. [17][18][19] Well-known selection rules allow for one to predict if a given vibrational mode is infrared-and/or Raman-active. Indeed, by considering the magnitude of the change in dipole moment or polarizability associated with a vibration, one can rationalize infrared or Raman data, respectively. Compared to Raman spectroscopy, SERS involves analyte molecules interacting with a roughened metal substrate, such that the symmetry ...

show abstract

“…[67] This strategy shares several analogies with the triosmium carbonyl cluster approach. In order to overcome this limitation, Van Duyne's group, who previously used self-assembled monolayers for SERS detection of glucose, reported a new sensing strategy using bisboronic acid receptors (two units of 4-amino-3-fluorophenylboronic acid).…”

Section: Detection Of Saccharidesmentioning

confidence: 99%

Plasmonic Detection of Carbohydrate‐Mediated Biological Events

Garcı́a

Mosquera

Plou

et al. 2018

Advanced Optical Materials

View full text Add to dashboard Cite

regulation of a variety of physiological and pathological processes, such as proliferation and adhesion, immune response, and cell differentiation. [8] The biological roles of carbohydrates as signaling effectors and recognition markers are associated to specific molecular recognition events in which proteins [9] or other carbohydrates [10] are involved. However, individual carbohydrate-based molecular interactions have been shown to be generally weak and, therefore, biomolecules usually present clusters of carbohydrates that interact cooperatively with their natural ligands (multivalent effect), thereby increasing the binding strength. [11] Interestingly, the multivalent carbohydrate presentation can be mimicked by man-made multivalent systems, which involve multiple synthetic oligosaccharides, [12][13][14][15][16][17] and have been used to address basic studies, but also as probe molecules and drugs. Mammalian cells are covered by a dense array of carbohydrates known as glycocalyx. The glycocalyx composition depends on the specific cellular state, and therefore it can provide information about diseases. For example, an increase of α-2,6-sialylation, fucosylation, and/or other tumor-associated carbohydrate antigens on the cellular membrane is considered as a biomarker of cancer progression, with diagnostic value. [18,19] In addition, oligosaccharides can be used as disease biomarkers for targeted therapy, and therefore the analysis and characterization of the composition of cellular glycans provide information of relevance to the diagnosis of several diseases. [20] Different strategies can be used to label glycans, including the use of covalent recognizing ligands (e.g., boronic acid), using specific carbohydrate-binding proteins, and via metabolic labeling.Plasmonics is based on the excitation of surface plasmons, that is, coherent oscillations of electrons induced by an electromagnetic radiation at metal-dielectric interfaces. [21] When the dimensions of plasmonic nanostructures are smaller than the wavelength of the incident light, the interaction between the electromagnetic field and surface charges results in nonpropagating oscillations denoted as localized surface plasmon resonances (LSPR). [22] LSPR frequencies in metal nanoparticles depend on their size, shape, organization, interparticle distance, and dielectric environment, ranging from the visible through the near-infrared (NIR). [23,24] A large volume of research has been devoted to the development of reliable methods for the preparation of plasmonic nanostructures with well-defined shape, size, and/or interparticle spacing, as basic components of various analytical applications. [25,26] Another important element, the surface chemistry of plasmonic The incorporation of nanomaterials in glycoscience research enables the design of highly selective and sensitive bioanalytical devices for the detection of disease-associated biomarkers. In particular, localized surface plasmon resonance (LSPR) and surface enhanced Raman scattering (SERS) spectroscopies ar...

show abstract

Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy

Cited by 107 publications

References 40 publications

The Three‐Dimensional Dendrite‐Free Zinc Anode on a Copper Mesh with a Zinc‐Oriented Polyacrylamide Electrolyte Additive

The Three‐Dimensional Dendrite‐Free Zinc Anode on a Copper Mesh with a Zinc‐Oriented Polyacrylamide Electrolyte Additive

Surface-enhanced Raman spectroscopy for in vivo biosensing

Plasmonic Detection of Carbohydrate‐Mediated Biological Events

Contact Info

Product

Resources

About