Bis(triphenylphosphine)copper(I) Complexes of Orotate and <scp>l</scp>-Dihydroorotate

Darensbourg, Donald J.; Larkins, David L.; Reibenspies, Joseph H.

doi:10.1021/ic980464m

Cited by 38 publications

(19 citation statements)

References 15 publications

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“…The average calculated of La-O bond lengths agree with the literature [77][78][79][80][81][82] and is specific for the monometallic complexes of lanthanum [60]. The increasing of M-O distances is related to decreasing of O-M-O angles [61].…”

Section: Geometry Optimizationsupporting

confidence: 77%

“…The La-O distances are in the range from 249.0 pm to 253.8 pm ( Table 2). The carboxylate groups exhibit bidentate coordination; the La(III) complex of HAOA, in this way formed, is mononuclear and each local coordination unit around the metal ion contains one 5-aminoorotate ligands [79][80][81][82]. The calculated C-O bond distances of the carboxylate groups from the complex are similar with those of the free ligand (around 132.5 pm) (Tables 1 and 2), value which could confirm that they are involved in hydrogen bonds formation [71,86,89,90].…”

Section: Geometry Optimizationmentioning

confidence: 99%

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Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

2006

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Section: Geometry Optimizationsupporting

confidence: 77%

Section: Geometry Optimizationmentioning

confidence: 99%

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

2006

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“…Other examples of structural characterization of Cu-carboxylate complexes, including both Cu(I) and Cu(II) oxidation states, have been reported. 30,[37][38][39][40][41][42][43][44] The structures of 1 and 2 reveal nearly linear C1-Cu1-O1 linkages with bond angles of 172.5(2)°and 171.1(1)°, respectively. The Cu-O bond distance of 1 is 1.838(2) Å, while that of 2 is 1.867(3) Å.…”

Section: Resultsmentioning

confidence: 99%

Single-Electron Oxidation of Monomeric Copper(I) Alkyl Complexes: Evidence for Reductive Elimination through Bimolecular Formation of Alkanes

et al. 2006

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Monomeric Cu(I) alkyl complexes (NHC)Cu(R) (NHC ) N-heterocyclic carbene; R ) Me or Et) and (dtbpe)Cu(Me) (dtbpe ) 1,2-bis(di-tert-butylphosphino)ethane) have been prepared, isolated, and characterized. Single-electron oxidation of the Cu(I) alkyl complexes upon reaction with AgOTf to form putative Cu(II) intermediates of the type [(L)Cu(R)] + (L ) NHC or dtbpe, R ) Me or Et) results in the rapid production of (L)Cu(X) (X ) OTf) and R 2 . Experimental studies suggest that the reductive elimination of R 2 from Cu(II) occurs through a nonradical bimolecular mechanism. Computational studies of the Cu-C methyl yield bond dissociation enthalpies of [(SIPr)Cu-CH 3 ] n+ (80 kcal/mol for n ) 0 {Cu(I)} and 38 kcal/mol for n ) 1 {Cu(II)}).

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“…24 The monobasic form, hydroorotate, H 2 L − , appears to predominantly form complexes with coordination through the carboxyl oxygen atoms. With the Cu(I) 25 and Zn(II) 26 cations, a bidentate coordination is observed whereas UO 2 (II) coordinates monodentately. 27 Compounds with the Zn(II) 28 and Mg(II) 29 cations, where the H 2 L − anion does not I.…”

Section: Introductionmentioning

confidence: 99%

New cerium(III) and neodymium(III) complexes as cytotoxic agents

Kostova

Rastogi

Kiefer

et al. 2006

Appl. Organometal. Chem.

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The cerium(III) and neodymium(III) complexes of 5-aminoorotic acid were synthesized and characterized by means of spectral data (IR, Raman, 1 H NMR and 13 C NMR) and elemental analysis. Significant differences in the IR spectra of the complexes were observed as compared with the spectrum of the ligand. A comparative analysis of the Raman spectra of the complexes with that of the free 5-aminoorotic acid allowed a straightforward assignment of the vibrations of the ligand groups involved in coordination. 1 H NMR and 13 C NMR spectra confirmed the formation of the complexes. The ligand and the complexes were tested for the cytotoxic activities on the chronic myeloid leukemia-derived K-562, overexpressing the BCR-ABL fusion protein, and the non-Hodgkin lymphoma-derived DOHH-2, characterized by a rexpression of the antiapoptotic protein bcl-2 cell lines. The results obtained indicate that the tested compounds exerted a considerable cytotoxic activity upon the evaluated cell lines in a concentration-dependent manner, which enabled the construction of dose-response curves and the calculation of the corresponding IC 50 values. Cytotoxicity towards tumor cells was determined for a broad concentration range. The inorganic salts exerted a very weak cytotoxic effect on these cells that is in contrast to the lanthanide complexes, which exhibited potent cytotoxic activity towards K-562 and DOHH-2 cell lines.

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Bis(triphenylphosphine)copper(I) Complexes of Orotate and l-Dihydroorotate

Cited by 38 publications

References 15 publications

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid

Single-Electron Oxidation of Monomeric Copper(I) Alkyl Complexes: Evidence for Reductive Elimination through Bimolecular Formation of Alkanes

New cerium(III) and neodymium(III) complexes as cytotoxic agents

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