Abstract:A simple and efficient method has been developed for the synthesis of amides promoted by PIFA [(bis(trifluoroacetoxy)iodo)benzene]. In this method, PIFA [(bis(trifluoroacetoxy)iodo)benzene] has been used as a useful promoter for the transamidation of dimethylformamide (DMF) with the amines. Besides, this hypervalent iodine smoothly promoted the N-formylation of various aromatic amines with formic acid. Notably, the small quantity of PIFA is found to be efficient for both strategies and large-scale synthesis ca… Show more
“…Due to the paramount importance of the amide functionality, numerous synthetic strategies have evolved over time. Kamble et al 50 presented an effective, mild, metal-free procedure for catalyzing the transamidation reaction using PIFA (Scheme 1). High yields of amide analogs 3 were achieved by employing various aromatic amines 1, predominantly those featuring fluoro substituents.…”
Iodine-containing molecules have garnered substantial attention in the realm of organic synthesis during recent decades. Higher oxidation state iodine compounds, often denoted as 'hypervalent iodine compounds,' have proven to be...
“…Due to the paramount importance of the amide functionality, numerous synthetic strategies have evolved over time. Kamble et al 50 presented an effective, mild, metal-free procedure for catalyzing the transamidation reaction using PIFA (Scheme 1). High yields of amide analogs 3 were achieved by employing various aromatic amines 1, predominantly those featuring fluoro substituents.…”
Iodine-containing molecules have garnered substantial attention in the realm of organic synthesis during recent decades. Higher oxidation state iodine compounds, often denoted as 'hypervalent iodine compounds,' have proven to be...
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