Bis(trichloromethyl) Carbonate in Organic Synthesis

Cotarca, Livius; Delogu, Pietro; Nardelli, A.; Šunjić, Vitomir

doi:10.1055/s-1996-4273

Cited by 208 publications

(104 citation statements)

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“…The catalyst is filtered off easily, and the inorganic reagent is washed In order to avoid the synthesis of the isocyanate using phosgene, three alternatives were tested. Diphosgene and triphosgene [16][17][18][19] are colourless solids and stable under ambient conditions. One molecule diphosgene releases two, triphosgene three equivalents of phosgene in situ.…”

Section: Resultsmentioning

confidence: 99%

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline

Olma¹,

Neumaier²,

Coenen³

2006

Labelled Comp Radiopharmac

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Four different no carrier added (n.c.a.) 4‐[18F]fluorophenylurea derivatives are synthesized as model compounds via two alternative routes. In both cases carbamate‐4‐nitrophenylesters are used as intermediates. Either n.c.a. 4‐[18F]fluoroaniline reacts with carbamates of several amines, or the carbamate of n.c.a. 4‐[18F]fluoroaniline is formed at first and an amine is added subsequently to yield the urea derivative. The choice of the appropriate way of reaction depends on the possibilities of precursor synthesis.The radiochemical yields reach up to 80% after 50 min of synthesis time while no radiochemical by‐products can be determined. These high yields were possible due to an optimized preparation of n.c.a. 4‐[18F]fluoroaniline with a radiochemical yield of up to 90%. From the various ways of its radiosynthesis, the substitution with n.c.a. [18F]fluoride on dinitrobenzene is chosen, using phosphorous acid and palladium black for reduction of the second nitro group. Copyright © 2006 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline

Olma¹,

Neumaier²,

Coenen³

2006

Labelled Comp Radiopharmac

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“…[22] Phosphorus-chlorine bonds are very useful for the elaboration of organophosphorus compounds. Triphosgene or (CCl 3 O) 2 CO, a crystalline substitute for toxic phosgene, [23] has been shown to efficiently transform primary phosphines to the dichlorides RPCl 2 and secondary phosphines to the chlorides RR'PCl. [24] Accordingly, the primary phosphine 2 and the secondary phosphine 5 were treated with triphosgene in THF as shown in Scheme 4 (middle, bottom).…”

Section: Derivatives and Related Chemistrymentioning

confidence: 99%

Convenient Modular Syntheses of Fluorous Secondary Phosphines and Selected Derivatives

2005

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“…Triphosgene was synthesized by chlorination of dimethylcarbonate; 13,14 it melted at 79°C, IR (KBr, cm…”

Section: Synthesismentioning

confidence: 99%

Synthesis and biological activity of novel N‐benzoyl‐N‐tert‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines

Wang

Cheng

Huang

2002

Applied Organom Chemis

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A series of new N-benzoyl-N-tert-butyl-N'-(b-triphenylgermyl)propionylhydrazines were synthesized by the condensation reaction of b-triphenylgermyl propanoic acid with N-benzoyl-N-tertbutylhydrazines in good yields by using N,N'-dicyclohexylcorbodiimide as dehydrating agent. These title compounds were evaluated for molting hormone mimicking activity. The results of bioassay showed that the compounds exhibit moderate larvicidal activity, and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We found that the title compounds possess potential anticancer activities in vitro.

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Bis(trichloromethyl) Carbonate in Organic Synthesis

Cited by 208 publications

References 0 publications

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline

Convenient Modular Syntheses of Fluorous Secondary Phosphines and Selected Derivatives

Synthesis and biological activity of novel N‐benzoyl‐N‐tert‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines

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Bis(trichloromethyl) Carbonate in Organic Synthesis

Cited by 208 publications

References 0 publications

4‐[18F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[18F]fluoroaniline

4‐[18F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[18F]fluoroaniline

Convenient Modular Syntheses of Fluorous Secondary Phosphines and Selected Derivatives

Synthesis and biological activity of novel N‐benzoyl‐N‐tert‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines

Contact Info

Product

Resources

About

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline

4‐[¹⁸F]fluorophenyl ureas via carbamate‐4‐nitrophenyl esters and 4‐[¹⁸F]fluoroaniline