Bis(hydrogen<scp>L</scp>-glutamato)palladium(II)

Seifert, Antje; Wagner, Christoph; Merzweiler, Kurt

doi:10.1107/s1600536811035860

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Bis-(glutamic acid)palladium(II) was characterized by elemental analysis and based on titration stoichiometry against ethylenediamine to form the [Pd(en) 2 ] 2+ cation and against thiourea to form the [Pd(thio) 4 ] 2+ cation. Seifert reported the crystal structure confirming the normal chelation of the alpha O, N groups [ 20 ]. Bis-(aspartic acid)palladium(II) was characterized in an identical manner.…”

Section: Introductionmentioning

confidence: 88%

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Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

et al. 2021

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The reaction of palladium(II) acetate with acyclic amino acids in acetone/water yields square planar bis-chelated palladium amino acid complexes that exhibit interesting non-covalent interactions. In all cases, complexes were examined by multiple spectroscopic techniques, especially HRMS (high resolution mass spectrometry), IR (infrared spectroscopy), and 1H NMR (nuclear magnetic resonance) spectroscopy. In some cases, suitable crystals for single crystal X-ray diffraction were able to be grown and the molecular structure was obtained. The molecular geometries of the products are discussed. Except for the alanine complex, all complexes incorporate water molecules into the extended lattice and exhibit N-H···O and/or O···(HOH)···O hydrogen bonding interactions. The non-covalent interactions are discussed in terms of the extended lattice structures exhibited by the structures.

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Section: Introductionmentioning

confidence: 88%

“…Basic R-groups are present in the palladium(II) complexes of histidine, arginine, and lysine (Figure 21). 19), arginine (20), and lysine (21). N,N chelation modes are possible for all of these complexes.…”

Section: Amino Acids With Charged Basic R-groupsmentioning

confidence: 99%

Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

et al. 2021

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Compounds of Amino Acids as Anions

Fleck

Petrosyan

2014

Salts of Amino Acids

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This chapter deals with salts formed from metal cations and amino acid anions. All amino acids can act as monovalent anion; the acidic members glutamic acid and aspartic acid as well as cysteine and tyrosine can form both monovalent and divalent anions. Due to the large number of available cations, a multitude of combinations is possible and in fact found (for the standard twenty amino acids, over 150 crystal structures are published, and many more species have been characterized by other methods). Different hydration states (as reported for the pristine amino acid crystals) occur as well, and the existence of polymorphs is also documented for some cases. The formation of metal-amino acid complexes has been studied in several works (both for a given amino acid and a given cation), and the flexibility of amino acid molecules as ligands allows coordination of cations with different chemical properties (such as charge or ionic radius). Several coordination modes are found for amino acids -the molecules can act as monodentate, bidentate, tridentate, and bridging ligands. The connectivity of the coordination polyhedra of the metal cations is considered -isolated units are frequent, but chains and layers occur as well. Moreover, these units can connect via amino acid molecules to form higher-dimensional structures. Hydrogen bonds (also involving water molecules, both in coordination or in the interstices as crystal water) further stabilize the units, forming relatively stable phases. The frequency of salts varies among the different amino acids, and most examples are reported for glycinate salts, whereas crystals of cations and basic and weakly soluble amino acids are difficult to obtain (e.g., arginate and lysinate salts have not been reported in crystalline state). Finally, the aspect of symmetry is considered (the chirality of most amino acids playing a crucial role), and, consequently, the properties of these salts have impact on applications in the fields of physics, biology, and medicine.

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Catalytic transfer hydrogenation and anticancer activity of arene–ruthenium compounds incorporating bi-dentate precursors

et al. 2015

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Ruthenium based organometallic compounds are presently a subject of great attention as anticancer drugs and appear to work reasonably well on tumor cells. We develop a series of mononuclear arene-ruthenium compounds incorporating N,O and N,N bidentate ligands, and their activity as anticancer drugs against human hormone-refractory metastatic prostate cancer (HRMPCs) cell lines are investigated. The ruthenium compounds also act as effective catalysts in the transfer hydrogenation of the -C[double bond, length as m-dash]O- → -CH(OH)- system. Three types of ligands, namely, sodium glutamate, C4H3NH(2-CH2NH(t)Bu), and C4H3NH(2-CH[double bond, length as m-dash]NR) are separately coupled with [(η(6)-cymene)RuCl2]2 () (cymene = 4-isopropyltoluene) to synthesize five Ru-derivatives: [(η(6)-cymene)RuCl(κ(2)-N,O-OOCCHNH2CH2CH2COOH)] (), {(η(6)-cymene)RuCl[C4H3N(2-CH2NH(t)Bu)]} (), {(η(6)-cymene)RuCl[C4H3N(2-CH[double bond, length as m-dash]NCH2Ph)]} (), {(η(6)-cymene)RuCl{C4H3N[2-CH[double bond, length as m-dash]NCH2(C4H7O)]}} () and {(η(6)-cymene)RuCl[C4H3N(2-CH(n)BuNHCH2(C4H7O))]} (). To the best of our knowledge, the aforementioned Ru compounds are not only characterized by (1)H and (13)C NMR spectroscopy, but for the first time their structures have been established by single crystal X-ray diffractometry. Compound influences a concentration-dependent apoptosis in PC-3 cells and initiates the conversion rate in transfer hydrogenation.

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Bis(hydrogenL-glutamato)palladium(II)

Cited by 3 publications

References 9 publications

Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

Compounds of Amino Acids as Anions

Catalytic transfer hydrogenation and anticancer activity of arene–ruthenium compounds incorporating bi-dentate precursors

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