Bis[di(imidazol-2-yl)phosphinato-N3,N3']platinum(II) tetrahydrate

Britten, James F.; Lock, C. J. L.; Wang, Zhixian

doi:10.1107/s0108270192013258

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…[10] In the complexes in the solid state, the amino group can be protonated and the metal ion is bound only by the phosphinate oxygen atom(s) [9,[11][12][13][14][15] or the phosphinic amino acids can behave as chelating ligands bound through amino and phosphinate groups. [8,9,16,17] In addition, the phosphinate moiety serves as a bridge between two metal ions, often forming characteristic eight-membered M-(O-P-O) 2 -M metallacycles. [8,11,[13][14][15] During the last decades, aminoalkylphosphinic acid groups have been used as building blocks in the design of polydentate ligands.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Coordination Behavior of Symmetrical Tetraamine Phosphinic Acids

Kubíček¹,

Řehoř²,

Havlíčková³

et al. 2007

Eur J Inorg Chem

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Two new tetraamine ligands, bis[N‐(2‐aminoethyl)aminomethyl]phosphinic acid (Hen2p) and bis[N‐(3‐aminopropyl)aminomethyl]phosphinic acid (Hpn2p), were synthesized from the corresponding diaminoalkanes and bis(chloromethyl)phosphinic acid. Their acid–base properties and complexation with Cu2+, Ni2+, and Zn2+ ions were studied by potentiometric titrations. Different chain lengths of the ligands result in significantly different coordination abilities. The five‐membered chelate ring of Hen2p leads to a higher stability of its complexes. In comparison with tetraamines having the same number of the bridging atoms separating the amino groups, the presence of the phosphinic acid moiety decreases the basicity of the amine groups, and consequently, the stability of their complexes. Several solid‐state structures were determined by X‐ray diffraction analysis. Four nitrogen atoms coordinate the Cu2+ or Zn2+ ion in a square‐planar fashion, whereas the phosphinic acid group is not coordinated or acts as a bridging unit between neighboring metal ions. The unexpectedly high stability of the Ni2+/Hpn2p complex can be explained by the possible presence of a tetramer in solution as was found in the solid state.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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Section: Introductionmentioning

confidence: 99%

Synthesis and Coordination Behavior of Symmetrical Tetraamine Phosphinic Acids

Kubíček¹,

Řehoř²,

Havlíčková³

et al. 2007

Eur J Inorg Chem

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“…On the other hand, little attention has been paid to coordination properties of (aminoalkyl)phosphinic acids in solution 12 and in the solid state. [13][14][15][16][17][18][19][20] The results indicate that, compared to (aminoalkyl)phosphonic and aminocarboxylic acids, the amino groups in (aminoalkyl)phosphinic acids are weakly basic and the phosphinic acid groups are often strongly acidic. Consequently, the complexes exhibit lower stability constants.…”

Section: Introductionmentioning

confidence: 99%

Complexes of divalent transition metal ions with bis(aminomethyl)phosphinic acid in aqueous solution and in the solid state

et al. 2003

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Bis(aminomethyl)phosphinic acid, (NH 2 CH 2 ) 2 PO 2 H (HL), was synthesized using a new procedure. Its coordination ability towards Co()/(), Ni(), Cu() and Zn() was studied both in solution and in the solid state. Because of the presence of two nitrogen atoms the ligand exhibits a higher overall basicity than common (aminoalkyl)phosphinic acids. Consequently, the values of the determined stability constants are comparable with those found for (aminoalkyl)phosphonic acids. NMR titrations of Zn() point to the interaction of phosphinate with the metal ion in a strong acid solution. The X-ray structures show several coordination modes in the solid state. All-trans-, where M() are Mn(), Co(), Ni(), Cu(), Zn(), Ca(), and Cd(), crystallized from acid solutions. The central ion is octahedrally coordinated with two phosphinate oxygen atoms, two molecules of water and two chlorides in all-trans arrangement. Amine groups are protonated and non-coordinated. Participation of the donor groups in crystals isolated from neutral solutions depends on the metal ion. All donor atoms are coordinated in monomeric fac-N,N,O-trans-O,OЈ-[Co(L-N,N,O) 2 ] ϩ . On the other hand, in the zinc() complex, two phosphinate oxygen atoms and two amine nitrogen atoms (trans to each other) of two different ligand molecules are coordinated in an equatorial plane and two amino groups of the two other ligand molecules are bound in axial positions. Thus, each molecule of the amino acid forms a five-membered N,O-chelate to one zinc() ion and the other amino group is bound to the neighbouring ion creating an infinite chain. Nickel() forms a trans-O,OЈ-[Ni(H 2 O) 2 -(L-N,N) 2 ] complex in which the metal ion is chelated by four amine nitrogen atoms forming two six-membered chelates in an equatorial plane and the octahedron is completed with two water molecules at the apical positions. The phosphinate group is not coordinated. The above results point to a relatively low coordination ability of the phosphinate group; however, due to its low pK A , it is able to bind metal ions at lower pH than other coordinating groups do.

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“…Such a type of ligand decomposition by P-C cleavage reactions has already been observed in analogous monophosphanes. For example, tris(imidazol-2-yl)phosphane (2-TIP NH ) decomposes to the corresponding bis(imidazol-2-yl)phosphinic acid [30,31], and a recent example from our group also shows this reactivity for bis(N-methylimidazol-2-yl)phenyl phosphane (2-BIP NMe ) [32]. In the structures 3 and 5, the center of the ethylene group is localized on a two-fold rotational axis and a center of inversion respectively.…”

Section: Decomposition Of 2-dimpementioning

confidence: 99%

Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex

Noffke

Bongartz

Wätjen

et al. 2011

Journal of Organometallic Chemistry

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The tetranuclear ruthenium arene compound [(cym)4Ru4(2)Cl6]Cl2 (3) (cym = 6-p-cymene, 2 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane) was prepared and characterised by one-and twodimensional NMR techniques. Its cytotoxicity against four different cell lines was determined and, with an approximate IC50 of >100 M 3 can be regarded as non-toxic. Its partition coefficient in n-octanol/water (log D7.4) was also determined. The structures of complex 3 as well as of the related compound [(cym)2Ru2(4)Cl2]Cl2 (5) (4 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane dioxide) were determined by single crystal structure analysis. Upon oxidation in protic solvents, ligand 2 shows P-C bond cleavage reactions to yield P,P-bis(N-methylimidazol-2-yl)ethylene diphosphinic acid (6). [ ‡] X-ray structure analysis. KeywordsImidazolylphosphanes, Phosphane Ligands, PN Ligands, Ruthenium AbstractThe tetranuclear ruthenium arene compound [(cym) 4 Ru 4 (2)Cl 6 ]Cl 2 (3) (cym = η

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Bis[di(imidazol-2-yl)phosphinato-N3,N3']platinum(II) tetrahydrate

Cited by 4 publications

References 5 publications

Synthesis and Coordination Behavior of Symmetrical Tetraamine Phosphinic Acids

Synthesis and Coordination Behavior of Symmetrical Tetraamine Phosphinic Acids

Complexes of divalent transition metal ions with bis(aminomethyl)phosphinic acid in aqueous solution and in the solid state

Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex

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