Bis(benzimidazole) Complexes, Synthesis and Their Biological Properties: A Perspective

Abstract

Benzimidazoles are a very well-known, broad group of compounds containing nitrogen atoms in their structure that can mimic properties of DNA bases. The compounds show not only biological activities but also are used for spectral and catalytic properties. Biological activity of benzimidazoles can be tuned and accelerated in coordination compounds. This minireview is focused on preparation of bis(benzimidazoles), their complexes, and biological properties that can be found from 2015.

Bis[2,6-bis(benzimidazol-2-yl)pyridine-κ3 N,N′,N′′]nickel(II) bis(trifluoromethanesulfonate) diethyl ether monosolvate

“…Complexes bearing 2,6-bis(2-benzimidazolyl)pyridine (bbp) as a chelating ligand have garnered considerable interest due to their application in biological systems (Icsel et al, 2020a;Singh et al, 2023;S ˇindela ´r ˇ& Kopel, 2023). Recently, a nickel(II) saccharinate 2,6bis(2-benzimidazolyl)pyridine complex has shown considerable anticancer effects against A549 and MCF-7 cancer cells (Icsel et al, 2020b).…”

Design, synthesis, antimicrobial activity and molecular docking study of cationic bis‐benzimidazole‐silver(I) complexes

“…Therefore, the development of new drug candidates against antimicrobial resistance is a necessity and therefore of interest to researchers. Consequently, the benzimidazole platform is particularly interesting due to its nitrogen atom being able to coordinate with transition metals [ 16–19 ] and especially with silver [ 20,21 ] or as a precursor of N ‐heterocyclic carbenes, for example, for bis‐silver complexes. [ 22,23 ]…”

“…Consequently, the benzimidazole platform is particularly interesting due to its nitrogen atom being able to coordinate with transition metals [16][17][18][19] and especially with silver [20,21] or as a precursor of N-heterocyclic carbenes, for example, for bis-silver complexes. [22,23] In this context, we now report the synthesis of eight cationic silver(I) complexes, in which two benzimidazole entities were coordinated through their nitrogen atom to the metal, and their antimicrobial activities against Gram-negative, Gram-positive, and Fungi strains.…”