Bis- and Trisindolylmethanes (BIMs and TIMs)

Recent progress of Ammonium chloride as catalyst in organic synthesis

“…23a,b On the other hand condensation of carbonyls and indoles give diindolylmethanes that show a wide variety of biological activities. 24 It was found that Ammonium chloride effectively catalyses both types reactions. …”

Comparison of the Catalytic Activity of Copper Nanostructures in Friedel‐Crafts‐Type Condensation Reactions

“…[5] Bis(indolyl)methanes, on the other hand, are known to have diverse biological activities, and their synthesis has received considerable attention during the past two decades. [6] Bis(indolyl)methanes also have been used as precursors for the synthesis of colorimetric chemosensors due to their affinity to a variety of anions and metal ions. [7À9] Condensation of indoles with aldehydes or ketones is a general route for the synthesis of bis(indolyl)methanes in the presence of either protic or Lewis acids.…”

“…[7À9] Condensation of indoles with aldehydes or ketones is a general route for the synthesis of bis(indolyl)methanes in the presence of either protic or Lewis acids. [6] Metal oxide nanoparticles, to a lesser extent, were used in the synthesis of bis(indolyl) methanes. Examples include SiO 2 nanoparticles in presence of ultrasound, [10] sulfated zirconia nanoparticles, [11] H 5 PW 10 V 2 O 40 / pyridino-Fe 3 O 4 nanoparticles, [12] TiO 2 nanoparticles, [13] sulfonic acid functionalized magnetic nanoparticles [14] and Fe(ox)-Fe 3 O 4 nanoparticles.…”

PEG1000-Based Dicationic Acidic Ionic Liquid/Solvent-Free Conditions: An Efficient Catalytic System for the Synthesis of Bis(Indolyl)methanes

“…Numerous indoles occur in many active medicine compounds for human health [1,2]. In particular, bis(indolyl)methanes possess a wide range of pharmaceutical activities, such as serving as anti-bacterial and anti-fungal agents [3][4][5][6].…”