Bis- and mixed-ligand copper(II) complexes of nalidixic acid the antibacterial drug: Mode of nalidixate coordination determines DNA binding and cleavage and cytotoxicity

Sharma, Mitu; Ganeshpandian, Mani; Sanjeev, Airy; Ajaykamal, Tamilarasan; Mattaparthi, Venkata Satish Kumar; Islam, Nashreen S.; Palaniandavar, Mallayan

doi:10.1016/j.ica.2020.119450

Cited by 17 publications

(8 citation statements)

References 82 publications

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“…The axial elongation in these ). [38][39][40][41] The distortions in the octahedral structures of complexes 1b, 2b, and 3b is further confirmed by the sum of bond angles 338.00°, 339.30°, and 345.05°, respectively, which (1b: ∠N-Cu-N′ = 176.17 (3)°), suggest that the equatorial plane is not perfectly square planar around the copper(II) center. 38,40,41 The relatively short bond lengths of the Cu-C bond of the NHC complexes (1b: 1.920(4), 2b: 1.935(8), 3b: 1.925(2) Å) in comparison to some of the previously reported Cu(II)-C bond lengths in the range of 1.91 to 2.01 Å may potentially leads to strong σ donation and π back bonding, attributable to the high stability of the complexes.…”

Section: Resultsmentioning

confidence: 85%

Three water-soluble copper(ii) N-heterocyclic carbene complexes: toward copper-catalyzed ketone reduction under sustainable conditions

Sharma,

Perkins,

Awoyemi

et al. 2024

Dalton Trans.

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Section: Resultsmentioning

confidence: 85%

Three water-soluble copper(ii) N-heterocyclic carbene complexes: toward copper-catalyzed ketone reduction under sustainable conditions

Sharma,

Perkins,

Awoyemi

et al. 2024

Dalton Trans.

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“…10 ). The molecular docking results with DNA show that these coordination compounds also interact in the minor groove [ 20 , 60 , 63 , 65 – 69 ]. Although the van der Waals contacts appear to be pivotal for the interaction with this groove, hydrogen bonding with nucleobases seems to be important for the stabilization into the domain [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium

et al. 2021

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Two square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies revealed that the two isostructural compounds were interacting differently with DNA. In both cases, the initial interaction involves electrostatic contacts of the CPYA ligand in the minor groove (as suggested by molecular docking), but subsequent strong binding occurs with the palladium(II) complex 2, whereas the binding with the copper complex 1 is weaker and concentration dependent. The strong binding of 2 eventually leads to the cleavage of the double strand and the redox activity of 1 allows to oxidatively cleave the biomolecule. Graphic abstract

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“…In 2020, another report was published by Islama and Palaniandavar's group [240] in continuation of their studies on NAL. They evaluated pUC19 DNA cleavage and cytotoxicity of Cu(II) complex, [Cu(ethylenediamine) 2 (NAL) 2 ] (100-Cu) , Fig.…”

Section: Amss In Pharma Studiesmentioning

confidence: 99%

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

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Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.

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Bis- and mixed-ligand copper(II) complexes of nalidixic acid the antibacterial drug: Mode of nalidixate coordination determines DNA binding and cleavage and cytotoxicity

Cited by 17 publications

References 82 publications

Three water-soluble copper(ii) N-heterocyclic carbene complexes: toward copper-catalyzed ketone reduction under sustainable conditions

Three water-soluble copper(ii) N-heterocyclic carbene complexes: toward copper-catalyzed ketone reduction under sustainable conditions

DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

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