Bis[(3-hydroxymethyl-5-methyl pyrazol)-1-yl Thiocarbonyl] Disulfide

Abstract

This experiment is performed according to literature method [1][2][3][4]. To a solution of bis[(3methoxycarbonyl-5-methyl pyrazol)-1-yl thiocarbonyl] disulfide 1 (7.3x10 -2 mol) in dry diethyl ether was added a solution of LiAlH 4 (2.78 g, 7.3x10 -2 mol) in 10 mL of dry ether. The mixture was stirred for 6h at 30 °C and the product was extracted with CHCl 3 dried over Na 2 SO 4 and filtred. The solvent was removed under reduced pressure and the product was dried under high vacuum.

Anticancer Activities of bis(pyrazol-1-ylthiocarbonyl)disulfides against HeLa cells

“…IR spectra of compounds 4-6 showed bands assignable to the υ(C=S) and υ(C-S) vibrational modes in the region of 1334-1254 cm -1 and 869-901 cm -1 , respectively. The structures of 4 and 5 were confirmed by single crystal X-ray crystallography, and have structures similar to the closely related bis [(3,5-dimethylpyrazol-1-yl)ethyl]disulfide reported by Mills et al 18 and bis[(3-hydroxymethyl-5-methylpyrazol-1-yl) thiocarbonyl]disulfide reported by El ldrissi et al 19 Orange crystals suitable for single crystal X-ray analysis were obtained from slow evaporation of THF solutions of 4 and 5. The crystal data are presented in Table 1, while molecular structures and selected bond distances and angles are shown in Compounds 1-6 (Scheme 1) were screened for their antitumour activities against human cervix epithelial carcinoma (HeLa) cells and human lymphocytes (PBMCs).…”