Bis(3,5‐dimethyl‐4‐vinylpyrazol‐1‐yl)acetic Acid: A New Heteroscorpionate Building Block for Copolymers that Mimic the 2‐His‐1‐carboxylate Facial Triad

Abstract

The new N,N,O ligand bis(3,5-dimethyl-4-vinylpyrazol-1-yl)-acetic acid (Hbdmvpza) (4) suitable for copolymerisation was synthesised in a multi-step synthesis starting from bis(3,5-dimethylpyrazol-1-yl)methane (1). The

Transition metal complexes bearing a 2,2-bis(3,5-dimethylpyrazol-1-yl)propionate ligand: one methyl more matters

“…Due to their k 3 -N,N,O coordination behaviour they are especially of interest for model complexes regarding zinc and iron enzymes with a 2-His-1-carboxylate metal binding motif. 8 Nevertheless, we decided to study the influence of substituents at the bridging position in detail. So far, a variety of such ligands has been designed by implementing suitable solid phase linkers or polymerization active groups at the bridging carbon atom of Hbdmpza (1) (Fig.…”

“…1-5 In our past investigations, we focused on the modification of bis(pyrazol-1-yl)acetic acids in order to make them suitable for solid phase fixation. [6][7][8]11 decays rapidly at -40 • C, the tetramethyl substituted macrocyclic ligand TMC increases the lifetime of the Fe(IV) O moiety drastically, due to a restricted access to the oxo group. 1).…”

One-pot microwave-assisted synthesis of 2,5-bis(pyrazol-4-yl)[1,3]thiazolo[5,4-d][1,3]thiazoles from pyrazole-4-carbaldehydes and dithiooxamide

“…[18][19][20][21][22][23] Furthermore, pyrazoles are used as agrochemicals, and applied in modern practical disinsection. [24][25][26] Pyrazoles are used in supramolecular and polymer chemistry, 27 as cosmetic colorings and UV stabilizers. 19,28 They are also used to design of complexes with unusual magnetic properties.…”

Novel directed synthesis of functionalized pyrazole derivatives via regioselective solvent-free thiylation of 3-alkenylpyrazoles with arenethiols

“…18 Some pyrazole ligands can be used in transition metal-catalyzed reactions. 19 Pyrazoles are used in supramolecular 20 and polymer chemistry, 21 in the food industry, as cosmetic colorings 22 and UV stabilizers 23 and some possess liquid crystal properties. 24,25 They are also applied in the design of complexes with unusual magnetic properties.…”

“…[1][2][3][4][5][6][28][29][30][31][32][33][34][35][36][37][38][39] The chemical transformations of alkenylpyrazoles are still poorly understood. It is known that N-alkenyl-and some 4-alkenylpyrazoles can participate in polymerization, 21,29 complex formation, 30,31 thiylation, 32 and cycloaddition. [33][34][35] Imidoalkylation of 1-, 3-, 4-, and 5-vinylpyrazoles with N-(2,2,2-trichloroethylidene)ethoxycarbonylamines is also reported 34,36 Chemical transformations of the difficult-to-access 3-alkenylpyrazoles 36-38 and 3-alkenyl-5-chloropyrazoles 28 are even less studied and only very few reactions with oxygen and sulphur nucleophiles have been published.…”