. LOCK. Can. J. Chem. 65, 2855 (1987). The complex [Pt(C9H14N2)2]C12 .4H20 was isolated from a reaction mixture containing K2[PtCI4] and a norbornane-based diamine, C9H !4N2. This product was analyzed with use of elemental analysis, nuclear magnetic resojance spectrosco y, and X-ray crystallography. [Pt(C9H14N2)2]C12.4H20 crystallized in the triclinic system, space group P I , a = 9.437(1) 1, b = 9.975(1) A, c = 6.888(1) A, a = 109.54(1)", P = 109.71(1)", y = 93.63(1)", Z = 1. The X-ray data were collected with use of a Syntex P2, diffractometer and MoKa radiation and the structure solved by the heavy atom method. Based on 1983 reflections, the structure was refined to R = 0.0310 and R,, = 0.0408. The platinum resides on an inversion center and is coordinated to the nitrogen atoms of the secondary amines. The chelating N-Pt-N angle is 79" but otherwise the bond lengths and angles agree well with values for similar structures.
IntroductionThe anti-cancer drug cis-dichlorodiammineplatinum(II), cisplatin, represents a group of platinum(I1) complexes that show anti-tumour activities (1). The major drawback to administering cisplatin is its renal toxicity (2). It has been shown, however, that replacement of the amine ligands by either cyclic amines or bulky amines reduces the toxicity (3, 4). We have attempted to prepare platinum complexes of the bulky polycyclic amine 2,7-diazatetracyclo[6.3.0.04~9.05~11]undecane, C9H14N2. TWO compounds were isolated from the reaction, the first a brown, insoluble powder, probably of a polymeric nature, and the second as colourless, plate-like crystals. This second compound was identified by single crystal X-ray diffraction and was shown to be trans-bis(2,7-diazatetracyclo[6.3 .0.04*9.~5,' 'lundecane-N,Nf)platinum(II) dichloride tetrahydrate, A. The compounds were also examined by infrared and 'H and 13c nmr spectroscopy. The expected 1 : 1 p1atinum:diamine complex, cis-dichloro(2,7-diazatetracyclo[6.3.0.04~9.05~1 'Iundecane-N,Nr )-platinum(II), B, was not isolated.