Birthweight Discordance in Multiple Pregnancy

Blickstein, Isaac; Kalish, Robin B.

doi:10.1375/136905203322686536

Cited by 88 publications

(51 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is an extensive medical literature examining the determinants of birth weight differences (called discordance) among twins. See Blickstein and Kalish [2003] for a summary.…”

Section: Datamentioning

confidence: 99%

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes

Black¹,

Devereux²,

Salvanes³

2005

182

219

View full text Add to dashboard Cite

Lower birth weight babies have worse outcomes, both short-run in terms of one-year mortality rates and longer run in terms of educational attainment and earnings. However, recent research has called into question whether birth weight itself is important or whether it simply reflects other hard-to-measure characteristics. By applying within twin techniques using an unusually rich dataset from Norway, we examine the effects of birth weight on both short-run and long-run outcomes for the same cohorts. We find that birth weight does matter; despite short-run twin fixed effects estimates that are much smaller than OLS estimates, the effects on longer-run outcomes such as adult height, IQ, earnings, and education are significant and similar in magnitude to OLS estimates.

show abstract

“…There is an extensive medical literature examining the determinants of birth weight differences (called discordance) among twins. See Blickstein and Kalish [2003] for a summary.…”

Section: Datamentioning

confidence: 99%

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes

Black¹,

Devereux²,

Salvanes³

2005

182

219

View full text Add to dashboard Cite

show abstract

“…Thought to represent a special category of stunted fetal growth, twins have a higher risk of diseases associated with lower birth weight and major incidence of morbidity and mortality (Blickstein & Kalish, 2003). In particular, monochorionicity has been associated with an increased rate of adverse perinatal outcomes when compared with dichorionicity.…”

mentioning

confidence: 99%

Selective Intrauterine Growth Restriction in Monochorionic Twin Pregnancies: Markers of Endothelial Damage and Metabolomic Profile

et al. 2013

View full text Add to dashboard Cite

The aim of this study was to assess the aorta-intima thickness (aIT) and serum metabolomic profile in selective intrauterine growth-restricted (sIUGR) monochorionic diamniotic (MCDA) twin fetuses presenting Doppler velocimetry alterations. Fetal abdominal aIT was measured by ultrasound at 32 weeks of gestation, enrolling 24 MCDA twin fetuses (8 sIUGR and 16 controls). sIUGR twin fetuses were classified into two groups: Group 1 consisted of sIUGR with abnormal umbilical artery (UA) Doppler waveforms and Group 2 included sIUGR with normal UA Doppler. Group 3 were control fetuses appropriate for gestational age (AGA). Fetal blood samples were obtained from the umbilical vein immediately after fetal extraction. A non-targeted metabolomic profiling investigated fetal metabolism alterations by using liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Median fetal aIT was significantly larger in Group 1 (median value = 0.9 mm; range = 0.8-1.0 mm; p < .002) and Group 2 (median value = 0.8 mm; range = 0.7-0.8 mm; p < .002) than in AGA Group 3 (median value = 0.5 mm; range = 0.4-0.6 mm; p < .002). Metabolomic analyses, performed on four sIUGR cases (Group 1) compared with four AGA co-twins, showed an upregulation of phenylalanine, sphingosine, glycerophosphocholine, and choline, and a downregulation of valine, tryptophan, isoleucine, and proline sIUGR Group 1 compared with AGA. Although for metabolomics data only a statistical tendency (and not a statistical significance) was reached due to the small sample size, we believe that our results represent a valid starting point for further in-depth metabolomic and proteomic investigations of sIUGR in MCDA fetuses.

show abstract

“…Future pharmaceutical therapies and innovative alternative nutritional/environmental strategies even could maximize population-based wellbeing [45]. …”

Section: Resultsmentioning

confidence: 99%

Application of Intima Media Thickness Measurement and Omics in Intrauterine Growth Restriction Disease

Cosmi¹

2014

Cardiol Pharmacol

View full text Add to dashboard Cite

Intrauterine growth restriction is defined as a fetus with an estimated fetal weight less than 10th percentile for gestational age and cardiovascular changes, usually detected by means of Doppler ultrasonography. Noncommunicable diseases (such as cardiovascular diseases -CVD-and diabetes) still represent the main cause of mortality and morbidity in the industrialized world. Various studies support the hypothesis, formulated by Barker, that an adverse intrauterine environ-ment results in physiological adaptations of the fetus, maximizing its immediate chances for survival, but with detri-mental effects in adulthood. Low birth weight caused by IUGR was recently known to be associated with increased rates of CVD, non-insulin dependent diabetes in adult life, and neuromotor development alteration.The ultrasound-based measurement of fetal aorta intima media thickness (aIMT) represents an easy marker to investigate the pre-atherosclerotic changes.Omics research holds great promise for discoveries in nutrition research, including profiles and characteristics of dietary and body proteins; metabolism of nutrients; functions of nutrients and other dietary factors in growth, reproduction, and health. The proteome and metabolome analysis are expected to play an important role in understanding pathophysiological molecular mechanisms and in solving major nutrition-associated problems in humans, such as IUGR and cardiovascular disease.This review focuses the importance to identify a class of fetuses at risk of cardiovascular disease in utero, childhood and adult life, combining clinical and omics markers. It should be interesting to combine functional and structural information discovered to develop preventative and/or interventional therapeutic strategies.

show abstract

Birthweight Discordance in Multiple Pregnancy

Cited by 88 publications

References 25 publications

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes

Selective Intrauterine Growth Restriction in Monochorionic Twin Pregnancies: Markers of Endothelial Damage and Metabolomic Profile

Application of Intima Media Thickness Measurement and Omics in Intrauterine Growth Restriction Disease

Contact Info

Product

Resources

About