Birthweight and sodium/proton exchanger activity in the term human placenta

Sibley, Colin P.; D'Souza, S W; Doughty, Ian; Boyd, R. D.; Glazier, Jocelyn D.; Kuruvilla, A; Mahendran, D.

doi:10.1016/0143-4004(95)90105-1

Cited by 5 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its activity was lower in vesicles from placentas of growth-retarded babies and higher in those from macrosomic babies born to diabetic women, compared with vesicles from placentas of normally grown babies; in both cases, however, the effect was significant only at the 10 % level. Nevertheless, when we pooled the data from the two studies (Sibley, D'Souza, Doughty, Boyd, Glazier, Kuruvilla & Mahendran, 1995), we found a highly significant positive correlation between Na+-H+ exchanger activity and birthweight (Fig. 4).…”

Section: Na+-h+ Exchanger Activity and Fetal Growthmentioning

confidence: 99%

See 1 more Smart Citation

Placental transporter activity and expression in relation to fetal growth

Sibley¹,

Glazier²,

D'Souza³

1997

Experimental Physiology

View full text Add to dashboard Cite

SUMMARYThe question of whether there are causative or compensatory changes in placental transport physiology affecting fetal growth is considered. Reductions in uterine and umbilical blood flow in growth retardation will reduce maternofetal exchange of lipophilic solutes, such as 02 and CO2, but will not have a major effect on the transfer of hydrophilic solutes. These solutes are transferred across the placenta by paracellular diffusion, transporter protein-mediated transport and endocytosis-exocytosis. Neither paracellular diffusion nor endocytosis-exocytosis has been investigated in relation to fetal growth. The weight of evidence is that there is no change in the activity and expression of the syncytiotrophoblast GLUT1 glucose transporter in fetal growth retardation. However, there is strong evidence that the activity of the system A amino acid transporter, per milligram of placental membrane protein, is altered in relation to fetal growth, but in a complex manner. There is also some weaker evidence that the activity of the Na+-H+ exchanger, per milligram of placental membrane protein, is directly related to birth-weight. There are no data for other solute transporters; a considerable amount of work still remains to be done in order to understand the relationship between placental function and fetal growth rate.

show abstract

Section: Na+-h+ Exchanger Activity and Fetal Growthmentioning

confidence: 99%

“…The linear regression hats ian r-2 value of 025, P < 0001 (n = 43). From Sibley et al (1995), with permission. (Hiiussinger, Lang & Gerok, 1994).…”

Section: Na+-h+ Exchanger Activity and Fetal Growthmentioning

confidence: 99%