1998
DOI: 10.1056/nejm199802263380905
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Births after Intracytoplasmic Injection of Sperm Obtained by Testicular Extraction from Men with Nonmosaic Klinefelter's Syndrome

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Cited by 217 publications
(61 citation statements)
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“…So, beside the psychological benefit for these patients to know the etiology of their infertility, detection of Klinefelter syndrome allows for androgenic substitutive therapy and follow-up for other health problems that can accompany this genetic problem. In our experience the majority of patients with Klinefelter syndrome chose assisted reproduction with a donor without reluctance, but some patients with nonmosaic Klinefelter syndrome can rely on ICSI with testicular sperm extraction after genetic counseling (Palermo et al, 1998;Reubinoff et al, 1998).…”
Section: Discussionmentioning
confidence: 97%
“…So, beside the psychological benefit for these patients to know the etiology of their infertility, detection of Klinefelter syndrome allows for androgenic substitutive therapy and follow-up for other health problems that can accompany this genetic problem. In our experience the majority of patients with Klinefelter syndrome chose assisted reproduction with a donor without reluctance, but some patients with nonmosaic Klinefelter syndrome can rely on ICSI with testicular sperm extraction after genetic counseling (Palermo et al, 1998;Reubinoff et al, 1998).…”
Section: Discussionmentioning
confidence: 97%
“…Most KS patients have small testes and azoospermia (no spermatozoa in the semen). The treatment for infertility in KS patients consists of the combination of testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI) (Palermo et al, 1998;Poulakis et al, 2001). Interestingly, Schiff et al performed micro-dissection TESE on 54 adult KS patients with azoospermia and successfully retrieved spermatozoa from 29 KS patients.…”
Section: Discussionmentioning
confidence: 99%
“…A recent study demonstrated gradual germ-cell depletion in early puberty as testicular volume increases, accompanied by a gradual increase of gonadotropin levels, explaining the resultant hypergonadotropic hypogonadism and infertility [22]. However, cases of proven paternity in mosaic or non-mosaic Klinefelter men have been documented, and assisted reproduction techniques with intracytoplasmic sperm injection (ICSI technique) offer the possibility of paternity even in cases of non-mosaic Klinefelter syndrome patients [23, 24]. However, increased incidence of chromosomal aneuploidies is documented in the offsprings of these men [25, 26].…”
Section: Discussionmentioning
confidence: 99%