Birth weight is the most important predictor of abnormal retinal vascularisation in moderately preterm infants

Allvin, Kerstin; Hellström, Ann; Dahlgren, Jovanna; Grönlund, Marita Andersson

doi:10.1111/apa.12599

Cited by 18 publications

(24 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with the findings of a neonatal study on MLP infants, BW seems to be an important marker for abnormal retinal vascularization (Allvin et al. ). Visual acuity was found to be correlated with GA, that is with every gain of one gestational week, decreases the risk of poor visual outcome.…”

Section: Discussionsupporting

confidence: 85%

Ophthalmological findings in relation to auxological data in moderate‐to‐late preterm preschool children

Raffa

Aring

Dahlgren

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To evaluate ophthalmological findings in preschool children born moderate-to-late preterm (MLP) and relate the findings to auxological data at birth and at 5.5 years of age. Methods: Seventy-eight MLP children [gestational age (GA) 32-36 weeks; 34 girls; mean age 5.7 years] were investigated. Gestational age, weight, length and head circumference at birth and at the time of assessment were registered. Visual acuity (VA), refraction, orthoptic evaluation, slit-lamp examination and ophthalmoscopy were conducted, and a history of visuoperceptual problems was recorded. The data were compared with age-and sex-matched controls born full term (n = 35). Results: Ophthalmological abnormalities were noted in 82% of MLP children and 47% of controls (p = 0.0004). There was a significant difference with regard to impaired motility (p = 0.03), heterophoria at distance (p = 0.006) and refraction expressed as spherical equivalent dioptre (p = 0.01). Amongst auxological data at birth, birthweight (BW) was the strongest predictor to ophthalmological abnormalities (p = 0.0003). In a stepwise logistic regression, GA was the strongest predictor of VA outcome at time of assessment (p = 0.0036). Moderate-to-late preterm birth showed a 2.4-fold increased risk of refractive errors compared with full-term children (RR 2.39: 95% CI 1.10-5.20; p = 0.02). Conclusion: Based on our findings, MLP birth may be associated with increased ocular morbidity compared with their full-term counterparts. Auxological data at birth, especially BW, seems to be an important factor when conducting an ophthalmological diagnosis in preschool MLP children, and an increased VA was correlated to a higher GA.

show abstract

Section: Discussionsupporting

confidence: 85%

Ophthalmological findings in relation to auxological data in moderate‐to‐late preterm preschool children

Raffa

Aring

Dahlgren

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…This might distort perceptions of the role of growth restriction in disease processes (8). A recent study found that among moderate-to-late preterm infants, low birthweight was the strongest predictor of abnormal retinal vascularisation (3). Despite the abnormal vascularisation, none of these infants had ROP, likely due to the older gestational age of the sample (≥32-week gestation at birth).…”

Section: Discussionmentioning

confidence: 99%

“…Low gestational age and low birthweight due to intrauterine growth restriction (IUGR) are independent risk factors for retinopathy of prematurity (ROP) (1,2). In moderately to late preterm infants, low birthweight has been associated with abnormal retinal vascularisation (3).…”

Section: Introductionmentioning

confidence: 99%

Prethreshold retinopathy in premature infants with intrauterine growth restriction

et al. 2014

View full text Add to dashboard Cite

Aim To determine, among very preterm newborns, if those who are growth restricted are at increased risk of retinopathy of prematurity (ROP), and to explore if the mixed findings of prior studies are the consequence of sampling based upon birth weight instead of gestational age. Methods Using data from the ELGAN Study, we created logistic regression models of pre-threshold ROP risk to adjust for confounders and calculate odds ratios and 99% confidence intervals. We created scatter plots to display the gestational age/birth weight relationship in infants enrolled in studies with different selection criteria. Results Low gestational age (23–24 weeks, OR 11.6 (2.9, 47); 25–26 weeks, 8.1 (2.1, 32)) and severe growth restriction (birth weight Z-score <−2, OR 9.1 (1.1, 76)) were associated with increased risk of pre-threshold ROP. We documented in scatter plots that a sample defined by birth weight has an excess of gestationally-older, severely growth-restricted newborns. Conclusion In this sample, low gestational age and severe growth restriction were associated with increased risk of pre-threshold ROP.

show abstract

“…from 30 weeks of gestation to 18 years. We found 23 studies reporting on measures of weight status (88%) as exposure, 23,28,38,39,[55][56][57][58][59][60][61][62][63][64][65][68][69][70][71][72][73][74][75] while measures of PA were present in six studies (23%) 41,64-67, 73 and SB was assessed in three studies (12%) 28,41,73 ; four studies (15%) reported measures of weight status and PA/SB. 28,64,65,73 Adiposity assessments included birthweight (n = 5), BMI (n = 11), OCT device, non-mydriatic vessel analyzer and a spectralis OCT device (4% each).…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 97%

“…We found 20 cross-sectional studies. The exposures varied between birthweight, 56,59,70,73 BMI, 23,28,38,39,55,[57][58][59]61,62,65,69,72 WC, 28,38,55,57 other measures of adiposity, 28,39,58,61,68,71 SB 28,41,73 and PA. 41,65,67,73 One study stated that children born with low-birth-weight were 4% more likely to have abnormal vascularisation than normal birthweight children. 70 Also, Kandasamy et al, 56 found that low birthweight was related to larger arterioles and venules.…”

Section: Cross-sectional Associationsmentioning

confidence: 99%

Systematic review on retinal microvasculature, physical activity, sedentary behaviour and adiposity in children and adolescents

et al. 2020

View full text Add to dashboard Cite

Aim As retinal microvasculature (RMV) can be assessed non‐invasively, it presents an opportunity to examine the health and disease of the human microcirculation, as RMV alterations have been recognised as one of the earliest signs of cardiovascular risk. This review summarises current literature on the associations between physical activity (PA), sedentary behaviour (SB) and/or adiposity and RMV in children and adolescents aged 0‐18 years. Methods Six databases were searched (MEDLINE, Scopus, Web of Science, ScienceDirect, PsycINFO and CINAHL), through to December 11, 2019. English, Portuguese, French, Spanish or Dutch were the languages searched. Meta‐analyses were performed using the meta‐analyst software. Results A total of 6796 studies were screened, and 26 studies were included, representing 24 448 participants, from 12 different countries. Studies reporting results on weight status were twenty‐three, PA was assessed in six studies, and SB was assessed in three studies. Four studies examined weight status and PA/SB. Meta‐analysis was performed for two studies and showed that children with obesity have smaller retinal arterioles (−2.38 µm difference, 95% CI 0.62, 4.15 µm) and larger retinal venules (2.74 µm difference, 95% CI −4.78, −0.72 µm) than children without obesity. Conclusion Results showed that adiposity was associated with microvascular alterations in children and adolescents. Increased adiposity, lack of PA and high levels of SB were negatively correlated with vessel width parameters.

show abstract

Birth weight is the most important predictor of abnormal retinal vascularisation in moderately preterm infants

Abstract: In this population of moderately to late preterm newborns, birth weight appeared to affect the retinal vascular system.

Cited by 18 publications

References 28 publications

Ophthalmological findings in relation to auxological data in moderate‐to‐late preterm preschool children

Ophthalmological findings in relation to auxological data in moderate‐to‐late preterm preschool children

Prethreshold retinopathy in premature infants with intrauterine growth restriction

Systematic review on retinal microvasculature, physical activity, sedentary behaviour and adiposity in children and adolescents

Contact Info

Product

Resources

About