Birth Weight and Neurocognition in Schizophrenia Spectrum Disorders

Freedman, David; Bao, Yuanyuan; Kremen, William S.; Vinogradov, Sophia; McKeague, Ian W.; Brown, Alan S.

doi:10.1093/schbul/sbs008

Cited by 22 publications

(31 citation statements)

References 34 publications

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“…These findings have implications for understanding brain development because they point toward a diagnosis-independent dose response, rather than dichotomous, association between prenatal adversities, and adult cortical anatomy and outcome, not only in LBW or psychotic subjects, as previously reported, 7,19 but also in healthy and normal BW subjects. This is of importance to general obstetric health care, and in particular, the care for pregnant women with psychotic disorders or women with disadvantaged environmental living conditions.…”

Section: Discussionsupporting

confidence: 60%

“…The positive association between BW and working memory was present in all groups except in schizophrenia patients, in contrast to a study of a smaller cohort in which BW was associated with working memory in schizophrenia patients but not controls. 19 It is biologically plausible that abnormalities in cortical circuitry underlying cognitive impairments have a prenatal origin because cortical neurons are generated, cortical pathways develop, and cortical synaptogenesis begins prenatally. 41 BW was, however, not associated with IQ, in contrast to previous reports, 17 including a study that used the same premorbid IQ estimate.…”

Section: Discussionmentioning

confidence: 99%

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Normal Birth Weight Variation Is Related to Cortical Morphology Across the Psychosis Spectrum

Haukvik

Rimol

Roddey

et al. 2013

Schizophrenia Bulletin

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Background: Normal birth weight variation affects schizophrenia risk and cognitive performance in schizophrenia patients and healthy controls. Brain cortical anatomy is altered in psychotic disorders and in low birth weight subjects, but if birth weight variation relates to cortical morphology across the psychosis spectrum is not known. Methods: Magnetic Resonance Imaging brain scans and clinical-, neurocognitive-, and medical birth registry data were collected from 359 adults including patients with a DSM-IV diagnosis of schizophrenia (n = 90, mean age 29.4 ± 10.2 [95% CI], 62% male), bipolar disorder (n = 79, age 29.4 ± 11.8, 39% male) or other psychosis (n = 40, age 26.3 ± 10.0, 56% male), and healthy controls (n = 140, age 30.8 ± 12.0,53% male). We explored the relationship between whole-range birth weight variation and cortical surface area and thickness and their possible associations to cognitive performance. Results: Across all groups, lower birth weight was associated with smaller total surface area (t = 3.87, P = .0001), within specific regions of the temporal, parietal, and frontal cortex bilaterally. There were no associations between birth weight and cortical thickness, and no diagnosis by birth weight interaction effects on cortical thickness or surface area. Smaller cortical area (t = 2.50, P = .013) and lower birth weight (t = 2.53, P = .012) were significantly related to poorer working memory performance in all diagnostic groups except schizophrenia. Conclusion: Birth weight relates to adult cortical surface area, but not cortical thickness, in patients across the psychosis spectrum and in healthy controls. Cortical area appears to be a diagnosis-independent general marker of early neurodevelopment, with a doseresponse association to normal birth weight variation.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Normal Birth Weight Variation Is Related to Cortical Morphology Across the Psychosis Spectrum

Haukvik

Rimol

Roddey

et al. 2013

Schizophrenia Bulletin

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“…10 Retrospective cognitive analyses showed that, at age 13 years, individuals in whom schizophreniform disorder subsequently developed performed significantly worse on the TMT than controls. 34 In addition to an association with deviations during adolescence, TMT impairment in patients with schizophrenia has also been associated with deviations during fetal life (in utero maternal infection exposures).…”

Section: Discussionmentioning

confidence: 99%

“…8 An association between lower birth weight, a global proxy measure of uterine "optimality," 9 and neurocognitive deficits has also been found in patients with schizophrenia-spectrum disorders compared with controls. 10 In this context, the aim of our study was to investigate the influences of early brain deviation on executive deficit in patients with schizophrenia. We considered different clinical and radiological markers of early brain development that were reportedly associated with schizophrenia liability and cognitive impairments: neurological soft signs (NSS), 11 mixed handedness, 12 ventricle enlargement 13 and cortex morphology (sulcation).…”

Section: Introductionmentioning

confidence: 99%

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Plaze

Oppenheim

Gaillard

et al. 2017

JPN

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“…For instance, maternal nutritional deficits can induce persistent changes in metabolism within the offspring (2) Hence, brain development throughout childhood and adolescence (and beyond) may be influenced by factors that occur in utero. Cognitive functioning and behavioral problems, such as in Attention Deficit Hyperactivity Disorder, personality disorders, and schizophrenia (3,4) as well as other psychopathology (5) with an established neural basis, have been linked with fetal growth and adversity. However, normal variation in birth weight, one of the most commonly used indicators of fetal growth and perinatal health, is substantial, even among typically developing individuals.…”

mentioning

confidence: 99%

Long-term influence of normal variation in neonatal characteristics on human brain development

Walhovd

Fjell

Brown³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

165

163

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It is now recognized that a number of cognitive, behavioral, and mental health outcomes across the lifespan can be traced to fetal development. Although the direct mediation is unknown, the substantial variance in fetal growth, most commonly indexed by birth weight, may affect lifespan brain development. We investigated effects of normal variance in birth weight on MRI-derived measures of brain development in 628 healthy children, adolescents, and young adults in the large-scale multicenter Pediatric Imaging, Neurocognition, and Genetics study. This heterogeneous sample was recruited through geographically dispersed sites in the United States. The influence of birth weight on cortical thickness, surface area, and striatal and total brain volumes was investigated, controlling for variance in age, sex, household income, and genetic ancestry factors. Birth weight was found to exert robust positive effects on regional cortical surface area in multiple regions as well as total brain and caudate volumes. These effects were continuous across birth weight ranges and ages and were not confined to subsets of the sample. The findings show that (i) aspects of later child and adolescent brain development are influenced at birth and (ii) relatively small differences in birth weight across groups and conditions typically compared in neuropsychiatric research (e.g., Attention Deficit Hyperactivity Disorder, schizophrenia, and personality disorders) may influence group differences observed in brain parameters of interest at a later stage in life. These findings should serve to increase our attention to early influences.

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Birth Weight and Neurocognition in Schizophrenia Spectrum Disorders

Cited by 22 publications

References 34 publications

Normal Birth Weight Variation Is Related to Cortical Morphology Across the Psychosis Spectrum

Normal Birth Weight Variation Is Related to Cortical Morphology Across the Psychosis Spectrum

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Long-term influence of normal variation in neonatal characteristics on human brain development

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