Birth Weight and Blood Cholesterol Level: A Study in Adolescents and Systematic Review

Owen, Christopher G.; Whincup, Peter H.; Odoki, Katherine; Gilg, Julie; Cook, Derek G

doi:10.1542/peds.111.5.1081

Cited by 86 publications

(68 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our unadjusted estimate combined for both sexes is similar to that found in a recent meta-analysis of the association between birth weight and total cholesterol in which an increase in 1 kg of birth weight was associated with a 0.05-mmol/L reduction in total cholesterol. 10 Some of the previous studies in smaller European samples of a similar age have reported a significant negative association between birth weight and total cholesterol 6,52 consistent with our unadjusted findings in men. Others report no association, 3,11,12,14,53 and one study showed a significant negative association after adjustment for age, smoking, alcohol, and BMI.…”

Section: Discussionsupporting

confidence: 90%

“…No study found an association with LDL cholesterol and some have found an association with HDL. 11,14,45,52 Although some studies of adults found significant relationships when men and women were analyzed together, 10 when males and females were analyzed separately in these same studies significant relationships were only seen in men. 13,42,54 These agree with our findings of a possible sex difference in effect in total cholesterol, and studies that have analyzed men and women together may have obscured a relationship in men.…”

Section: Discussionmentioning

confidence: 96%

“…3,4 Results from studies relating markers of fetal growth to adult lipid levels have, however, been inconsistent 3,[5][6][7][8][9] and a recent meta-analysis estimated a decrease of only 0.05 mmol/L per 1 kg increase in birth weight. 10 To our knowledge, all except one study 7 of European adults 3,5,6,8,[11][12][13][14][15] have fewer than 800 subjects and may therefore have lacked the power to test for sex differences. Sex differences in the association between fetal growth and later coronary heart disease risk might be anticipated if fetal nutrition is the underlying mechanism because male fetuses grow at a faster rate, on average, than female fetuses.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Birth Weight and Lipids in a National Birth Cohort Study

Skidmore

Hardy

Kuh

et al. 2004

ATVB

View full text Add to dashboard Cite

Objective-To investigate the association between birth weight and lipid levels in a 53-year-old birth cohort from England, Scotland, and Wales. Methods and Results-Lipid levels were obtained from nonfasting blood samples, collected at the most recent follow-up of the MRC National Survey of Health and Development, for 2559 men and women. Regression models indicated that in men, a 1-kg increase in birth weight was associated with a 0.13-mmol/L decrease (95% CI: Ϫ0.23, Ϫ0.01) in total cholesterol at age 53 years (Pϭ0.03), compared with a 0.02-mmol/L (95% CI: Ϫ0.11, 0.15) increase in women and a 0.06-mmol/L (95% CI: Ϫ0.15, 0.02) decrease in men and women combined. Adjustment for current height and body mass index (BMI) in men reduced the size of the relationship, with height being responsible for the reduction. Adult height and height at 2 and 4 years were significantly associated with total cholesterol in men and in men and women combined. The negative association between total cholesterol and birth weight was strongest among men with high BMI at age 53 years (Pϭ0.03 for test for interaction between birth weight and BMI). There was no significant association between birth weight and LDL or HDL cholesterol in men or women before adjustment, but there was a positive association with HDL in women. When both sexes were analyzed together, an association was seen after adjustment for current body size. No confounding of these findings with social class was observed in this study. Conclusions-Our results suggest that the small effect of birth weight on lipid levels at age 53 years has a limited public health impact. The findings suggest that childhood height growth may be more important than prenatal growth. Key Words: birth weight Ⅲ height Ⅲ body mass index Ⅲ cholesterol Ⅲ epidemiology H igh blood cholesterol is an important risk factor for cardiovascular disease 1 and may be programmed in early life. 2 According to Barker's fetal origins hypothesis, 2 impaired fetal growth that leads to changes in lipid metabolism is one explanation for the observed inverse associations between birth weight and other measures of size at birth and adult cardiovascular disease. 3,4 Results from studies relating markers of fetal growth to adult lipid levels have, however, been inconsistent 3,5-9 and a recent meta-analysis estimated a decrease of only 0.05 mmol/L per 1 kg increase in birth weight. 10 To our knowledge, all except one study 7 of European adults 3,5,6,8,[11][12][13][14][15] have fewer than 800 subjects and may therefore have lacked the power to test for sex differences. Sex differences in the association between fetal growth and later coronary heart disease risk might be anticipated if fetal nutrition is the underlying mechanism because male fetuses grow at a faster rate, on average, than female fetuses. 16 However, discussion of sex differences based on separate analyses for males and females, without statistical tests of interaction, may result in an overemphasis of chance differences. 17 Adjustment of the birth weight effec...

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Birth Weight and Lipids in a National Birth Cohort Study

Skidmore

Hardy

Kuh

et al. 2004

ATVB

View full text Add to dashboard Cite

show abstract

“…Secondly, it is said that people who were exposed to famine in the uterus will develop non-communicable diseases (NCD) with "thrifty genes" expressing insulin resistance (Barker 2004). Several systematic reviews have reported inverse associations between birth weight and blood pressure (Huxley et al 2000), serum glucose level (Whincup et al 2008), total cholesterol concentration (Owen et al 2003) and metabolic syndrome (Silveira and Horta 2008). Miura et al (2001) reported inverse associations between birth weight and blood pressure and serum cholesterol in a Japanese cohort population.…”

mentioning

confidence: 99%

Association between Low Birth Weight and High Adult Waist-to-Height Ratio in Non-Obese Women: A Cross-sectional Study in a Japanese Population

Harada

Torii

Saruwatari

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Low birth weight has been associated with cardiovascular diseases. The waist-to-height ratio is a good indicator of risks for these diseases. The objective of this study was to examine the associations between birth weight and adult waist-to-height ratio in a Japanese population. A cross-sectional study, comprised of 851 subjects (401 men and 450 women) aged 35-62 years who were born at full term, was conducted at a medical checkup. The subjects responded to a questionnaire about weight at birth, and data on physical characteristics were collected from the results of the medical checkup. The subjects were stratified with sex and a Body Mass Index of 25 kg/m 2 to elucidate the effects of birth weight on adult waist-to-height ratio. Analysis of covariance was used to compare the physical condition among the 4 birth weight categories. After adjusting for age, alcohol consumption, smoking status and exercise, the height was significantly lower in the birth weight < 2,500 g category among men (P < 0.001) and women (P < 0.001), while the waist-to-height ratio was significantly higher in the birth weight < 2,500 g category, compared with the > 3,500 g category in the non-obese women (P = 0.004), but not in the obese women. In conclusion, low birth weight was independently associated with a low adult height among men and women and with a high adult waist-to-height ratio among non-obese women. Our results suggest that intrauterine environmental insults might lead to accumulation of visceral fat among non-obese women.

show abstract

“…Obesity has a strong effect on lipoprotein metabolism, regardless of ethnic groups [24][25][26] . Increased weight is a determinant of higher levels of triglycerides, elevated LDL-C, and low HDL-C. Conversely, weight loss is associated with a healthier lipoprotein profile in both genders.…”

Section: Obesity and Other Cardiovascular Risk Factorsmentioning

confidence: 99%

Obesity and cardiovascular disease

Pérez

Muñoz

Cortés

et al. 2007

Public Health Nutr.

View full text Add to dashboard Cite

Background: The prevalence of obesity has reached epidemic proportions, and in terms of the extent of its negative impact on the health has been compared to those of tobacco and alcohol. One of the first medical consequences of obesity to be recognised was cardiovascular disease (CVD). Obesity, particularly abdominal obesity, predisposes a person to a number of other cardiovascular risk factors, and is an independent predictor of clinical CVD including coronary death, coronary heart disease, heart failure and stroke. Materials and methods: A Medline search using the following keywords (obesity, cardiovascular disease, body mass index, cardiovascular risk factors, type 2 diabetes, metabolic syndrome) was performed looking for high impact factor English-written references. Results: Ninety-nine (N 5 99) relevant articles published in the last 15 years were selected and commented. As detailed throughout the text, current therapies available for weight management can improve or prevent many of these obesityrelated risk factors for CVD. However, there is some controversy as to whether weight loss is beneficial for health, and large clinical outcome trials such as the Look-AHEAD (Action for Health in Diabetes) trial or the SCOUT (Sibutramine Cardiovascular Outcomes Trial) study are currently ongoing. Discussion: In the present review, we summarise the effects of obesity as well as the efficacy of weight-loss interventions on cardiovascular risk factors and CVD.

show abstract

Birth Weight and Blood Cholesterol Level: A Study in Adolescents and Systematic Review

Abstract: The relation of fetal nutrition to TC appears to be weak and is probably of limited public health importance when compared with the effects of childhood obesity.

Cited by 86 publications

References 56 publications

Birth Weight and Lipids in a National Birth Cohort Study

Birth Weight and Lipids in a National Birth Cohort Study

Association between Low Birth Weight and High Adult Waist-to-Height Ratio in Non-Obese Women: A Cross-sectional Study in a Japanese Population

Obesity and cardiovascular disease

Contact Info

Product

Resources

About