Birth prevalence for congenital limb defects in the northern Netherlands: a 30-year population-based study

Vasluian, Ecaterina; Sluis, Corry K. van der; Essen, Anthonie J. van; Bergman, Jorieke E. H.; Dijkstra, Pieter U.; Reinders-Messelink, Heleen A.; Walle, Hermien E. K. de

doi:10.1186/1471-2474-14-323

Cited by 86 publications

(87 citation statements)

References 28 publications

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“…Polydactyly and syndactyly were the second and third most common CLDs in our study, which is consistent with other studies in both western and Asian countries (Aro et al ; Padilla et al ; Zhang et al ; Li et al ; Vasluian et al ) including the studies in Thailand noted earlier (Siripoonya and Tejavej ; Dissaneevate et al ). Polydactyly occurred in the upper extremities three times as often as in the lower extremities, while syndactyly affected the lower extremities at twice the rate as in the upper extremities.…”

Section: Discussionsupporting

confidence: 93%

“…The prevalence rate of congenital limb reductions in our study was 0.18 per 1000 births which is within the variance of prevalence rates reported in other Asian countries of 0.15–0.42 per 1000 births (Siripoonya and Tejavej ; Dissaneevate et al ; Makhoul et al ; Padilla et al ; Zhang et al ; Li et al ). The reason for lower prevalence rates of limb reductions in Asian countries than the prevalence rates in western countries of 0.50–0.79 per 1000 births (Aro et al ; Froster‐Iskenius and Baird ; Evans et al ; McQuirk et al ; Rankin et al ; Dolk et al ; Parker et al ; Gold et al ; Vasluian et al ; Calzolari et al ) is currently unknown, but could be related to different genetic and environmental factors. In our study, limb reduction involved an upper limb or limbs about twice as often as lower limb or limbs, a finding which is similar to studies from both Caucasian and Asian countries (Aro et al ; Froster‐Iskenius and Baird ; Evans et al ; McQuirk et al ; Parker et al ; Gold et al ; Zhang et al ; Li et al ; Vasluian et al ; Calzolari et al ).…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence rates of CLD vary widely among countries, from 1–4 per 1000 live births depending on the definitions and classifications, notably in the inclusion or exclusion of minor limb defects (Aro et al ; Froster‐Iskenius and Baird ; Evans et al ; McQuirk et al ; Makhoul et al ; Padilla et al ; Byron‐Scott et al ; Rankin et al ; Dolk et al ; Parker et al ; Gold et al ; Zhang et al ; Li et al ; Vasluian et al ; Calzolari et al ; Seravalli et al ). There are currently few studies available of prevalences of limb anomalies in Asian countries.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand

Jaruratanasirikul

Tangtrakulwanich

Rachatawiriyakul

et al. 2016

Congenital Anomalies

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This is the first population-based study in Thailand on the prevalence of congenital limb defects (CLD). Data were obtained from recently established birth defects registries in three southern Thailand provinces during 2009-2013. Entries in the birth defects registries included live births, stillbirths after 24 weeks gestational age, and terminations of pregnancy following a prenatal diagnosis of fetal anomaly. The total of 186 393 births recorded included 424 CLD cases, giving an average prevalence of 2.27 per 1000 births (95% CI, 2.05-2.49). The most common CLD was talipes equinovarus (44.1%), followed by polydactyly (13.9%) and syndactyly (9.4%). The prevalence significantly increased with maternal age from 1.81 in mothers aged <30 years to 2.75 in mothers 30 to < 35 years, and to 2.94 in mothers ≥35 years (P = 0.004). Overall 9.4% of the CLDs were syndromic CLD, again with significantly greater percentages in pregnant women aged ≥35 years than the non-syndromic CLD (32.5% vs 17.5% respectively, P = 0.03). In conclusion, the overall prevalence of CLD in the 3 southern Thailand provinces examined was 2.27 per 1000 births, and syndromic CLD was significantly higher in pregnant women aged ≥35 years than younger pregnant women.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand

Jaruratanasirikul

Tangtrakulwanich

Rachatawiriyakul

et al. 2016

Congenital Anomalies

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“…10 A recent European study reported a prevalence of congenital limb defects as 21.1/10,000. 11 Other studies have reported different incidence of congenital malformations, Perveen and Tyyab reported a prevalence of 11.4/1000 births. In present study, the overall prevalence found was 6.7 per thousand live births.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of congenital limb anomalies in neonates

Parikh

Kalathia

Soodhana

2018

Int J Contemp Pediatr

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Background: Reported birth prevalence of congenital limb defects vary from country to country. Epidemiological studies permit the timely detection of trends in congenital limb anomalies and the associations with other birth defects. The objective of this study was to know the prevalence and the variety of congenital limb anomalies and their association with other anomalies.Methods: A prospective observational study in which all newborns reported to the neonatal department were surveyed to find out the incidence, diversity and association of limb anomalies. Age of the mother, risk factors and other demographic data of the newborns was analyzed. Babies born less than 28 weeks were excluded from the study.Results: The prevalence was 6.34 per thousand live births. The majority of the neonates were term babies and female. 28 % of the babies were born out of consanguineous marriage. The mean age of the mother was 25. Median parity was 1. 9.52 % of the babies had a history of anomaly in the sibling. 4.76 % had a history of still birth. The most common congenital anomaly was congenital talipo equino varus. The other congenital limb anomalies observed were polydactyly, syndactyly, bifid thumb and absence of the radius. There were multiple congenital anomalies in 28.57 % of the babies.Conclusions: The study has given us an insight into the variety of congenital limb malformations and also into the possible etiological factors. A study done on a larger population would probably help us assess the incidence and pattern of occurrence of limb anomalies and help us counsel the parents.

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“…1–8 To date, there is no commonly accepted measure of self-reported hand function among these children. Although some aspects of hand function can easily be obtained by functional assessment, such as grip or pinch strength, these measures do not always reflect disability.…”

mentioning

confidence: 99%

Applying the Patient-Reported Outcomes Measurement Information System to Assess Upper Extremity Function among Children with Congenital Hand Differences

Waljee

Carlozzi

Franzblau

et al. 2015

Plastic and Reconstructive Surgery

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Purpose Few studies have evaluated self-assessment tools among children with congenital hand differences. We compared three upper extremity disability instruments with the Patient Reported Outcomes Measurement Information System (PROMIS®) Pediatric Upper Extremity Item Bank. Methods Thirty-three children (ages 6–17) with congenital hand differences completed the Pediatric Outcomes Data Collection Instrument (PODCI), the Michigan Hand Outcomes Questionnaire (MHQ), the Disability of the Arm, Shoulder, and Hand (DASH), and the PROMIS® Upper Extremity short form (SF) and computerized adaptive test (CAT). Hand function was also assessed using grip and pinch strength and the Nine-Hole Peg Test. We used Spearman correlation coefficients to determine construct validity, and examined feasibility by comparing completion time, reading level, need for assistance, and patient preference among the instruments. Results PROMIS® demonstrated good construct validity. SF and CAT versions of PROMIS® were highly correlated with DASH scores (r > 0.80, p<0.001) and all PODCI domains except sports (r>0.70, p<0.001). Correlations with the MHQ were moderate (r> 0.40, p < 0.05). PROMIS® SF and CAT scores also correlated with grip strength (r≥0.60, p<0.001) and pinch strength (r>0.50, p<0.001). Compared to the other questionnaires, PROMIS® was much more feasible. It took the least time to complete, fewer children required assistance, and it is written at a lower, more age-appropriate reading level than the MHQ and DASH. Conclusions PROMIS® is highly correlated with both functional tests and traditional hand function questionnaires. Our results provide encouraging evidence that PROMIS® may be an efficient, feasible option to capture hand function among children with congenital hand differences. Level of Evidence: III

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Birth prevalence for congenital limb defects in the northern Netherlands: a 30-year population-based study

Cited by 86 publications

References 28 publications

Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand

Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand

Clinical profile of congenital limb anomalies in neonates

Applying the Patient-Reported Outcomes Measurement Information System to Assess Upper Extremity Function among Children with Congenital Hand Differences

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