Birth outcomes of cases with isolated atrial septal defect type II – a population‐based case‐control study

Vereczkey, Attila; Kósa, Zsolt; Csáky-Szunyogh, Melinda; Czeizel, Andr̀ew E.

doi:10.1111/aogs.12062

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…This finding has already been reported in other regions, with female prevalence of ASD that has not been surgical or transcatheter closed being 68% and prevalence in women who underwent surgical or transcatheter closed for ASD being 65% [28]. In an epidemiological study conducted in Hungary, it was found that the number of newborns with ASD was significantly higher in women than men after adjusting for the total number of newborns, suggesting a higher incidence in women [29]. This study may explain the higher prevalence of ASD in women.…”

Section: Discussionsupporting

confidence: 78%

Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam

Tuan

Kien²,

Cường

et al. 2019

JCDD

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Atrial septal defect (ASD) is a non-physiologic communication between the two atria, allowing the shunt between systemic and pulmonary circulation. Data about ASD prevalence among congenital heart disease patients (CHD) in Vietnam are still scarce. We aim to assess the trends in the prevalence of ASD patients and associated factors among CHD patients. This was a cross-sectional study, with data collected from medical records from 1220 CHD patients in Da Nang hospital from 1 January 2010 to 31 December 2015. Descriptive statistics were used to estimate the prevalence of ASD among CHD patients. Comparative statistical methods were used to compare groups and logistic regression to access associated factors with ASD. The overall prevalence of ASD among CHD patients was 18.5% between 2010 and 2015. The prevalence varied between periods, ranging between 15% and 31.9% during the period. The prevalence of ASD women among CHD (25.9%) was significantly higher than for men (16.0%). The prevalence of ASD increased gradually when the age group increased. The factors associated with increased ASD prevalence were being a female and being in an older age group. The findings suggest that targeted policy should provide more-specific health-care services of ASD for women and older patients.

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Section: Discussionsupporting

confidence: 78%

Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam

Tuan

Kien²,

Cường

et al. 2019

JCDD

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“…First, we compared maternal characteristics to select confounders such as age, birth order and employment status as the indicator of socio-economic status (20). These data were reported in our previous paper (13). Conditional logistic regression models were used to estimate the relative risk (odds ratio: OR) with 95% confidence intervals (CI) of ASD-II associated with maternal exposures during pregnancy in the group of cases compared with their matched controls.…”

Section: Discussionmentioning

confidence: 99%

“…Our study included only patients with isolated surgically corrected ASD-II, in order to evaluate cases affected with ASD-II as homogenous as possible in the population-based Hungarian Case-Control Surveillance of Congenital Abnormalities. The aim of the previous study was the evaluation of birth outcomes of patients with ASD-II (13) while the objective of this study is to estimate the possible causal risk factors in the origin of ASD-II.…”

Section: Introductionmentioning

confidence: 99%

Risk and Protective Factors in the Origin of Atrial Septal Defect Secundum - National Population-Based Case-Control Study

Csáky-Szunyogh¹,

Vereczkey

Czeizel

2014

Cent Eur J Public Health

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The aim of this study was to assess the risk factors in the origin of lethal or surgically corrected isolated atrial septal defect secundum. The population-based Hungarian Case-Control Surveillance of Congenital Abnormalities (conducted between 1980 and 1996) comprised 472 atrial septal defect secundum cases, 678 matched controls and 38,151 available controls without any defects; in addition, 21,022 malformed controls with other isolated defects. Medically recorded chronic disorders in the prenatal maternity logbook were evaluated, while acute maternal diseases, drug treatments and pregnancy supplements were analyzed on the basis of both prospective medically recorded data and retrospective maternal information. Acute pelvic inflammatory disease, paroxysmal supraventricular tachycardia and phenolphthalein treatment due to severe constipation of mothers were shown to contribute to the development of atrial septal defect secundum of their children. High doses of folic acid in early pregnancy had positively influenced a minor part of isolated atrial septal defect secundum in foetuses. In conclusion, the obvious genetic predisposition for atrial septal defect secundum is connected with maternal paroxysmal supraventricular tachycardia and triggered by acute pelvic inflammatory diseases and phenolphthalein treatment, while the manifestation of atrial septal defect secundum can be reduced by high doses of folic acid supplementation in early pregnancy.

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“…Three CHD-entities and/or groups are worth more discussion. i) Cases with ASD-II had localized small defect of an atrial septum (Fyler 1992, Vereczkey et al 2013), nevertheless, their mean gestational age was 1.2 wk shorter and their mean birth weight was 412 g smaller than population controls. The rate of PTB, LBW and SGA was 2.4.…”

Section: Discussionmentioning

confidence: 98%

Birth outcomes of cases with different congenital heart defects - a population-based study

Vereczkey

Gerencsér

Czeizel

et al. 2015

IJH

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Background: In general, previous epidemiological studies evaluated congenital heart defects (CHDs) together. The aim of the present study was to identify possible etiological factors of different CHD-entities, because the underlying causes are unclear in the vast majority of patients.Objectives: Different CHD-entities as homogeneously as possible with confirmed diagnoses were analyzed in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities.Methods: 3,750 live-born singleton CHD-patients were analyzed according to birth outcomes, i.e. gestational age at delivery and birth weight, the rate of preterm birth, low birthweight and small for gestational age.Results: The major findings of the study showed that cases with different CHD-entities had shorter gestational age at delivery and lower mean birth weight, and these variables associated with a higher rate of preterm birth and particularly with a much higher rate of low birthweight and small for gestational age. This study showed the importance of sex in the birth outcomes of some CHD-entities. The question is why several CHD-entities manifested more frequently in newborns with intrauterine growth restriction because fetal heart has a passive role before birth without pulmonary circulation.Conclusions: The birth outcomes of cases indicate the effect of CHDs for fetal development. In addition maternal confounders have to consider. Finally, CHDs and intrauterine growth restriction as two developmental errors may have a common route, thus fetal growth and birthweight associated gene polymorphisms may have a role in the origin of CHDs.

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Birth outcomes of cases with isolated atrial septal defect type II – a population‐based case‐control study

Cited by 3 publications

References 21 publications

Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam

Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam

Risk and Protective Factors in the Origin of Atrial Septal Defect Secundum - National Population-Based Case-Control Study

Birth outcomes of cases with different congenital heart defects - a population-based study

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