Birth outcomes of cases with conotruncal defects of heart – a population-based case-control study

Abstract

Objective. In general the previous epidemiological studies evaluated cases with congenital heart defects (CHDs) together. However, different CHD-entities have different etiology, but in the vast majority of patients the underlying causes are unclear. The concept of our project is to evaluate the possible etiological factors in the origin of CHD-entities as homogeneous as possible. The aim of this study is to describe the birth outcomes of 4 different types of cases with conotruncal defects (CTDs), i.e. common truncus (truncus arteriosus), transposition of great vessels, tetralogy of Fallot, and double-outlet right ventricle. Results. There was a male excess s in cases with CTD with usual gestational age and preterm birth rate (except in cases with common truncus), but their mean birth weight was smaller and had a high rate of low birthweight. These data indicate intrauterine growth restriction of fetuses affected with CTD with some sex-difference and the birth outcomes al so showed some difference among the 4 types of CTD cases.Conclusions. Fetal CTD had no effect for gestational age at delivery but CTD associated with an obvious risk for fetal development inducing intrauterine growth restriction.

Maternal Hypertension During Pregnancy and the Risk of Congenital Heart Defects in Offspring: A Systematic Review and Meta-analysis

“…2) (one additional study evaluated a CHD subtype but not CHDs overall [39]). Untreated maternal hypertension was significantly associated with CHDs overall (random-effect RR 1.4; 95 % CI 1.2, 1.7; heterogeneity p < 0.001).…”

“…Only one estimate of the effect of overall hypertension was considered in each study for this analysis. Thus, we used the effect estimate from each study based on the following priority: (1) untreated hypertension and CHDs overall; (2) treated hypertension (hypertension medications overall) and CHDs overall; (3) treated hypertension (specific hypertension medication used) and CHDs overall (i.e., some papers only evaluated one specific hypertension medication); and (4) untreated hypertension and specific CHD subtypes (i.e., one paper looked at a specific subtype and did not evaluate CHDs overall) [39]. …”

The Diagnostic Significance of Comorbidities of Congenital Heart Diseases, Low-Set Ears, and Intrauterine Growth Restriction in Neonates With Trisomies 13 and 18

“…The GATA6 gene is present on chromosome 18, and a mutation of this GATA6 gene is found in T18 patients with CHD ( 9 ). The comorbidity of CHD along with IUGR has been reported in some cases and in etiological studies ( 10 ). However, the embryological mechanisms associated with T13/18 remain unknown.…”