Birth outcomes of cases with left-sided obstructive defects of the heartin the function of maternal socio-demographic factors: a population-based case-control study

Vereczkey, Attila; Kósa, Zsolt; Csáky-Szunyogh, Melinda; Czeizel, Andr̀ew E.

doi:10.3109/14767058.2012.712568

Cited by 5 publications

(8 citation statements)

References 20 publications

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“…The main characteristics of the included studies are presented in Table S1 . As shown, 10 studies [28] – [30] , [32] , [33] , [35] , [36] , [39] , [43] , [44] were conducted in the United States or Canada, 6 in Europe [31] , [37] , [38] , [40] – [42] , and 1 in Asia [34] . Among these studies, 16 investigated the association between maternal parity as a binary variable and CHD risk [28] – [43] , and 14 examined the association of maternal parity number with CHD risk [28] , [30] – [34] , [36] , [38] – [44] .…”

Section: Resultsmentioning

confidence: 94%

“…Publication bias was not evident based on the Egger test ( P = 0.973) or Begg test ( P = 0.101), and no asymmetry was observed in the funnel plots. The 13 study-specific relative risks of parity ranged from a low of 1.05 (95% CI, 1.02–1.08; Q = 56.94; P = 0.000; I 2 = 78.9%) after omission of the study by Vereczkey and colleagues [40] to a high of 1.06 (95% CI, 1.03–1.10; Q = 51.12; P = 0.000; I 2 = 76.5%) after omission of the study by Cedergren and colleagues [42] .…”

Section: Resultsmentioning

confidence: 98%

“…3 ) with no publication bias (Begg's test: P = 0.443, Egger's test: P = 0.883). The 13 study-specific relative risks when considering the parity number ranged from a low of 1.17 (95% CI, 1.07–1.27; Q = 61.84; P = 0.000; I 2 = 80.6%) after omission of the study by Vereczkey and colleagues [40] to a high of 1.22 (95% CI, 1.12–1.34; Q = 59.74; P = 0.000; I 2 = 79.9%) after omission of the study by Batra and colleagues [30] .…”

Section: Resultsmentioning

confidence: 99%

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Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Feng

Chen

et al. 2014

PLoS ONE

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BackgroundEpidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted.MethodsWe searched MEDLINE and EMBASE for articles catalogued between their inception and March 8, 2014; we identified relevant published studies that assessed the association between maternal parity and CHD risk. Two authors independently assessed the eligibility of the retrieved articles and extracted data from them. Study-specific relative risk estimates were pooled by random-effects or fixed-effects models. From the 11272 references, a total of 16 case-control studies and 3 cohort studies were enrolled in this meta-analysis.ResultsThe overall relative risk of CHD in parous versus nulliparous women was 1.01 (95% CI, 0.97–1.06; Q = 32.34; P = 0.006; I2 = 53.6%). Furthermore, we observed a significant association between the highest versus lowest parity number, with an overall RR = 1.20 (95% CI, 1.10–1.31; (Q = 74.61, P<0.001, I2 = 82.6%). A dose–response analysis also indicated a positive effect of maternal parity on CHD risk, and the overall increase in relative risk per one live birth was 1.06 (95% CI, 1.02–1.09); Q = 68.09; P<0.001; I2 = 80.9%). We conducted stratified and meta-regression analyses to identify the origin of the heterogeneity among studies. A Galbraith plot was created to graphically assess the sources of heterogeneity.ConclusionIn summary, this meta-analysis provided a robust estimate of the positive association between maternal parity and risk of CHD.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Feng

Chen

et al. 2014

PLoS ONE

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“…The body of literature searched on the subject identified 26 studies which examined SES in relation to CHD development as listed in Table 1. The majority of the studies (18/26, 69%) examined individual maternal SES variables and the risk of CHD [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level [38][39][40][41], and still others (4/26, 15%) examined the individual, family and neighborhood SES to weigh the relative contribution of each level of the SES variables in CHD development [42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

“…Education was the variable most commonly assessed in these studies and the findings were largely inconclusive with some reporting associations between maternal education and CHD [21,[26][27][28] and others finding no associations [25,29,30]. Low skilled occupations and low income similarly were associated with CHD in some studies [22,26,32,33,37] and not in others [20,23,24,30,31]. In the United States, Egbe et al reported interesting findings on the relationship between income and CHD, where they documented an increased incidence of mild CHD among Caucasian populations in the upper quartiles of SES [34][35][36] compared to non-Caucasian minority populations.…”

Section: Advances In Pediatric Researchmentioning

confidence: 99%

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Ngwezi¹,

Hornberger²,

Osornio-Vargas³

2018

apr

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Introduction: Congenital heart disease (CHD) is the most common congenital anomaly affecting 1% of all live births of which the etiology remains unknown. The incidence is higher in developing countries likely related to low literacy, poverty and higher exposures to hazardous environmental nuisances. The role of socioeconomic status (SES) in CHD development has recently received attention. To gain the breadth of knowledge generated from existing publications, we undertook a scoping review of studies examining the relationship between SES and CHD. Methods: We searched databases using individual or combination of keywords which included non-Medical Subject Heading (non-MeSH) and MeSH terms. We included original observational studies using cohort, case control or ecologic study designs written in English and from 1980-2017. Results: We identified 26 studies, most of which were conducted in developed economies with very few from developing economies. The majority (18/26, 69%) examined individual maternal SES variables and the risk of CHD, whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level and others (4/26, 15%) examined the individual, family and neighborhood SES levels to weigh the relative contribution of each SES level in CHD development. Individual maternal low education and low skilled occupation were associated with CHD in half of the studies and another half of the studies found no associations between these variables and CHD. Evidence regarding the influence of neighborhood SES alone or multiple SES variables has been inconclusive as well. Conclusion: There is a paucity of studies from both developed and even more so from developing countries that have examined the influence of SES in CHD development. More knowledge regarding the contribution of various SES measures (i.e., individual, area level, and combinations) on CHD occurrence is required before relevant and effective interventions can be implemented.

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Risk Factors in the Origin of Congenital Left-Ventricular Outflow-Tract Obstruction Defects of the Heart: A Population-Based Case–Control Study

Csáky-Szunyogh¹,

Vereczkey²,

Kósa³

et al. 2013

Pediatr Cardiol

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The aim of our project was to study possible etiological factors in the origin of congenital heart defects (CHDs) because in the majority of patients the underlying causes are unclear. Cases with different CHD entities as homogeneously as possible were planned for evaluation in the population-based large data set of the Hungarian Case Control Surveillance of Congenital Abnormalities. Dead or surgically corrected 302 live-born cases with different types of left-ventricular outflow tract obstructive defects (LVOT, i.e., valvular aortic stenosis 76, hypoplastic left heart syndrome 76, coarctation of the aorta 113, and other congenital anomalies of aorta 32) were compared with 469 matched controls, 38,151 controls without any defects, and 20,750 malformed controls with other isolated defects. Medically recorded pregnancy complications and chronic diseases were evaluated based on prenatal maternity logbooks, whereas acute diseases, drug treatments, and folic acid/multivitamin supplementation were analyzed both on the basis of retrospective maternal information and medical records. The results of the study showed the role of maternal diabetes in the origin of LVOT in general, while panic disorder was associated with a higher risk of hypoplastic left heart syndrome and ampicillin treatment with a higher risk of coarctation of the aorta (COA). High doses of folic acid had a protective effect regarding the manifestation of LVOT, particularly COA. In conclusion, only a minor portion of causes was shown in our study; thus, further studies are needed to understand better the underlying causal factors in the origin of LVOT.

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Birth outcomes of cases with left-sided obstructive defects of the heartin the function of maternal socio-demographic factors: a population-based case-control study

Abstract: The general pattern of birth outcomes and maternal variables were similar in the types of LSOD cases, but the higher rate of preterm birth and low birthweight indicated some association with their adverse fetal development.

Cited by 5 publications

References 20 publications

Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Risk Factors in the Origin of Congenital Left-Ventricular Outflow-Tract Obstruction Defects of the Heart: A Population-Based Case–Control Study

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