Birth Outcomes and Rehospitalizations Among Pregnant Women With Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Offspring

Singh, Namrata; Sabo, Julianna; Crane, Deborah A.; Doody, David R.; Schiff, Melissa A.; Mueller, Beth A.

doi:10.1002/acr.25087

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…During these intervals, close monitoring was essential for minimizing harmful effects. The infants of women with SLE were more susceptible to abnormalities and death 11 .…”

Section: Discussionmentioning

confidence: 99%

Fetal and Neonatal Outcomes of Maternal Rheumatic diseases in a tertiary care centre of Lahore, Pakistan

Aslam¹,

Yasin²,

Ullah³

et al. 2023

PJMHS

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Background: Pregnancy may worsen underlying autoimmune rheumatologic illnesses. The trans-placental transmission of autoantibodies can harm the foetus or newborn. Aim: To determine the impact of maternal rheumatological disorders on fetal and newborn outcomes. Methods: A descriptive longitudinal study was conducted at Fatima Memorial Hospital enrolling 32 pregnant women with rheumatologic disorders by consecutive sampling. Data was collected regarding maternal demographics, diagnosis, serum markers, Fetal & neonatal outcome factors (IUGR, Fetal distress, Umbilical Doppler findings, Fetal Echo, Place of birth, Mode of delivery, discharge status, Term/pre-term birth, Gender, Low Birth Weight, Cardiac defect, NICU stay, the reason for NICU stay) Results: The diagnosis of 50% of the subjects was SLE. 25%subjects were suffering from RA. Regarding serum markers, 50% of the mothers were Anti ds DNA positive followed by ANA with 34.4% & Lupus anticoagulant with 21.9% positivity. IUGR was recorded in 9.4%, fetal distress in 28.1%, abnormal umbilical doppler in 9.4%, and 12.5% of a newborn could not survive. Pre-term delivery was recorded in 31.3% of cases, low birth weight in 34.4%, cardiac defects in 6.3%, thrombocytopenia in 6.3%, NICU stay was required in 31.3%, EOS was reason in 12.5% and RDS in 25%. Conclusion: Prevalence of IUGR, fetal distress, low birth weight, preterm delivery, cardiac defects and admission to NICU was high in autoimmune rheumatological pregnant females. Pre-term delivery, fetal distress and LBW were significantly associated with SLE. Keywords: Pregnancy outcome, rheumatic disease outcome, fetus, neonate, SLE

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“…During these intervals, close monitoring was essential for minimizing harmful effects. The infants of women with SLE were more susceptible to abnormalities and death 11 .…”

Section: Discussionmentioning

confidence: 99%

Fetal and Neonatal Outcomes of Maternal Rheumatic diseases in a tertiary care centre of Lahore, Pakistan

Aslam¹,

Yasin²,

Ullah³

et al. 2023

PJMHS

View full text Add to dashboard Cite

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A Cohort Study of Pregnancy and Fetal Complications Among Patients with Rheumatologic Disorders

Tafreshian,

Salari,

Mirfeizi

et al. 2024

J Obstet Gynecol India

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Rheumatoid arthritis and cardiovascular complications during delivery: a United States inpatient analysis

Zahid,

Mohamed,

Rajendran

et al. 2024

European Heart Journal

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Background and Aims Persons with rheumatoid arthritis (RA) have an increased risk of obstetric-associated complications, as well as long-term cardiovascular (CV) risk. Hence, the aim was to evaluate the association of RA with acute CV complications during delivery admissions. Methods Data from the National Inpatient Sample (2004–2019) were queried utilizing ICD-9 or ICD-10 codes to identify delivery hospitalizations and a diagnosis of RA. Results A total of 12 789 722 delivery hospitalizations were identified, of which 0.1% were among persons with RA (n = 11 979). Individuals with RA, vs. those without, were older (median 31 vs. 28 years, P < .01) and had a higher prevalence of chronic hypertension, chronic diabetes, gestational diabetes mellitus, obesity, and dyslipidaemia (P < .01). After adjustment for age, race/ethnicity, comorbidities, insurance, and income, RA remained an independent risk factor for peripartum CV complications including preeclampsia [adjusted odds ratio (aOR) 1.37 (95% confidence interval 1.27–1.47)], peripartum cardiomyopathy [aOR 2.10 (1.11–3.99)], and arrhythmias [aOR 2.00 (1.68–2.38)] compared with no RA. Likewise, the risk of acute kidney injury and venous thromboembolism was higher with RA. An overall increasing trend of obesity, gestational diabetes mellitus, and acute CV complications was also observed among individuals with RA from 2004–2019. For resource utilization, length of stay and cost of hospitalization were higher for deliveries among persons with RA. Conclusions Pregnant persons with RA had higher risk of preeclampsia, peripartum cardiomyopathy, arrhythmias, acute kidney injury, and venous thromboembolism during delivery hospitalizations. Furthermore, cardiometabolic risk factors among pregnant individuals with RA rose over this 15-year period.

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Birth Outcomes and Rehospitalizations Among Pregnant Women With Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Offspring

Cited by 5 publications

References 40 publications

Fetal and Neonatal Outcomes of Maternal Rheumatic diseases in a tertiary care centre of Lahore, Pakistan

Fetal and Neonatal Outcomes of Maternal Rheumatic diseases in a tertiary care centre of Lahore, Pakistan

A Cohort Study of Pregnancy and Fetal Complications Among Patients with Rheumatologic Disorders

Rheumatoid arthritis and cardiovascular complications during delivery: a United States inpatient analysis

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