Birth order in gout

Chase, Peter; Ellman, Alexander

doi:10.1002/art.1780100409

Cited by 2 publications

(1 citation statement)

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“…We found no association between number of older siblings and risk for gout and neither did Wallace et al in their study from 1967 [ 24 ]. Having older siblings has been used as a proxy for infections during childhood and adolescence with possible effects on the immune system, the higher number of older siblings the higher exposure to infections.…”

Section: Discussioncontrasting

confidence: 93%

Association between perinatal factors and future risk for gout—a nested case-control study

Dehlin

Jacobsson

2022

Arthritis Res Ther

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Background Increased level of urate is the strongest risk factor for gout development but since only a minority of hyperuricemics are affected by gout, other pathogenic factors must be considered. Low birth weight is associated with future morbidities causing hyperuricemia, such as diabetes and renal disease. The purpose of this study was to investigate if, and to what extent, maternal and perinatal factors, including birth weight, are associated with future risk of being diagnosed with gout. Methods A population-based retrospective nested case-control registry study based on regional and national health care registers in Sweden. All incident cases of gout born in 1973 and onward who had received ≥1 diagnosis of gout from 2000 through 2019 in the region of western Sweden were included. Up to 5 non-gout controls were matched to each case by age, sex, and county at the year of first gout diagnosis. A range of maternal, gestational, and perinatal factors were analyzed for their potential association to future gout development. This included the health of the mother, gestational length, birth weight, number of siblings, and congenital malformations. Results Maternal diabetes, any congenital malformation, and being small for gestational age were factors that significantly increased the risk for future gout development, odds ratio (95% CI) 3.1 (1.3 to 7.4) (p=0.01), 1.33 (1.04 to 1.7) (p=0.02), and 1.75 (1.3 to 2.3) (p<.0001), respectively. Conclusions In this study, maternal diabetes and being small for gestational age increased the risk for future gout development in young adults. As of today, these conditions are becoming more prevalent and may contribute to the ongoing gout epidemic. These results require both confirmation and further delineation of underlying mechanisms.

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Section: Discussioncontrasting

confidence: 93%