Birth order and paediatric allergic disease: A nationwide longitudinal survey

Kikkawa, Tomonobu; Yorifuji, Takashi; Fujii, Yoichi; Yashiro, Masato; Okada, Ayumi; Ikeda, Masanori; Doi, Hiroyuki; Tsukahara, Hirokazu

doi:10.1111/cea.13100

Cited by 23 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The noted positive associations between adiposity, cesarean delivery, and parental history of FA and the prevalence of study-defined FA are consistent with the findings of prior investigations 53, 54, 55. Similarly, the observed inverse association between birth order and the prevalence of study-defined FA is consistent with the findings of prior studies 4, 56. Although emerging evidence suggests that exposure to dogs in early life reduces the risk of FA,4, 52 our study showed that exposure to dogs in infancy was associated with an increased prevalence of study-defined FA, an association that needs further corroboration.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study

Ziyab

2019

World Allergy Organization Journal

View full text Add to dashboard Cite

Background Food allergy (FA) is a common public health problem that affects both children and adults. Empirical knowledge of the burden of FA in Kuwait is limited. This study sought to estimate the prevalence of FA among schoolchildren in Kuwait and assess associations between FA and the coexistence and severity of asthma, rhinitis, and eczema. Methods Schoolchildren aged 11–14 years (n = 3,864) were enrolled in a cross-sectional study. Parents completed questionnaires regarding their children's early life exposures and clinical history of FA and allergic diseases. Study-defined FA was ascertained by a convincing clinical history. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated. Results The 12-month prevalence of study-defined FA was estimated to be 4.1% (154/3,738), with more girls being affected than boys (aPR = 1.44, 95% CI: 1.04–1.99). Egg (2.7%), fish (1.6%), shellfish (1.3%), peanut (1.3%), and tree nut (1.2%) were the most reported offending food allergens. Underweight and adiposity, cesarean section delivery, exposure to household dogs during infancy, and parental history of doctor-diagnosed FA were associated with an increased prevalence of study-defined FA. However, later birth order was associated with a reduced prevalence of study-defined FA. The prevalence of eczema only was higher in children with study-defined FA than in those without study-defined FA (aPR = 3.49, 95% CI: 2.37–5.14). In contrast, this association was not pronounced for children who had asthma only (aPR = 1.56, 95% CI: 0.94–2.57) or rhinitis only (aPR = 1.40, 95% CI: 0.86–2.28). Study-defined FA was associated with a 9.20-fold (95% CI: 4.50–18.78) higher prevalence of coexisting asthma, rhinitis, and eczema. Moreover, study-defined FA was associated with increased severity of symptoms of asthma, rhinitis, and eczema. Conclusions FA affects a considerable proportion of schoolchildren in Kuwait, and the most reported offending food allergens are similar to those reported in Western countries. Study-defined FA was associated with the coexistence and increased severity of asthma, rhinitis, and eczema, indicating that FA may link the comanifestations of allergic diseases and contribute to their chronicity and severity.

show abstract

Section: Discussionsupporting

confidence: 88%

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study

Ziyab

2019

World Allergy Organization Journal

View full text Add to dashboard Cite

show abstract

“…The severity of AD has been associated with reduced levels of serum nutrients, such as omega-3 and -6 fatty acids, calcium, folate and vitamin D (29, 30) as well as a higher body mass index (31); while supplementation with a concoction of prebiotics and probiotics showed a significant improvement of AD, particularly among children with more severe AD forms (32). Furthermore, immune response to biological agents, such as S. aureus, has recently been indicated to influence the severity of AD (33), while higher levels of house dust mites have been reported to correlate with more severe AD in children (34). Thus, severe and persistent childhood AD, that represents a risk factor for the development of atopic comorbidities, such as allergic rhinitis or asthma, seems to be the result of complex interplay of genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Parental History of Atopic Diseases and Presence of Allergic Rhinitis and Asthma in Children with Atopic Dermatitis

Gazibara

Reljić

Nikolić

et al. 2020

CEJoP

View full text Add to dashboard Cite

Objective − To assess the prevalence of allergic rhinitis and asthma in children with and without parental history of atopic dermatitis (AD) as well as to explore the association between parental history of atopic diseases and presence of allergic rhinitis or asthma in children diagnosed with AD. Methods − From January to June 2014, we recruited a total of 98 children with AD and their parents who presented at the Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Serbia. The parents filled in a questionnaire. The severity of AD was assessed using the SCORing Atopic Dermatitis (SCORAD) Index. Results − Of 98 parents, 33 (33.7%) reported having history of AD. In children with parental history of AD, the prevalence of allergic rhinitis and asthma was 18.2% and 24.2%, respectively. In children without parental history of AD, the prevalence of allergic rhinitis and asthma was 12.3% and 23.1%, respectively. Adjusted logistic regression analyses showed that: neither mothers' nor fathers' history AD were associated with presence of allergic rhinitis or asthma; fathers' history of asthma was associated with presence of asthma and mothers' history of asthma was associated with presence of allergic rhinitis. Fathers' history of allergic rhinitis was associated with presence of allergic rhinitis and mothers' history of allergic rhinitis was associated with presence of asthma. Conclusion − Our findings suggest that, compared to parental history of AD, parental history of asthma and allergic rhinitis were stronger contributors to the presence of atopic comorbid disorders in children with AD.

show abstract

“…Fifteen covariates were a priori selected based for their potential impact on severe asthma from the data reported in literature: (15,16,31) Lifestyle factors (1 factor) : smoking (never vs. ever) (21,22,32) Early-life factors (6 factors): growing in countryside/farm (33), parental smoking (34), parental asthma and/or allergy (35), severe childhood infections (pneumonia before or during school age or hospitalization due to infection at ≤3 years of age) (36), number of siblings (<2 vs. ≥ 2) (24), birth order (1st vs. other) (24,37,38) Asthma characteristics (1 factor): non-steroidal anti-in ammatory drug (NSAID) -exacerbated respiratory disease (NERD) (17) Chronic comorbidities (3 factors): ≥1 other allergic disease ever [e.g. allergic rhinitis (AR)/allergic conjunctivitis (AC)/atopic dermatitis (AD)] (16,24), nasal polyps (NP) (18), ≥1 other chronic disease(s) (7,21,32).…”

Section: Covariatesmentioning

confidence: 99%

Risk Factors of Severe Adult-onset Asthma: A Multi-factor Approach

Toppila‐Salmi

Lemmetyinen

Chanoine

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The aim was to identify risk factors of severe adult-onset asthma.Methods: We used data from 1350 population-based asthmatics (Adult Asthma in Finland) with adult-onset asthma (age range 31-93 years) from Finnish national registers. Severe asthma was defined as self-reported severe asthma AND asthma symptoms causing much harm AND regular impairment AND (≥1 oral corticosteroid course/year OR regular oral corticosteroids OR wake up in the night due to asthma symptoms/wheezing attach ≥ a few times/month). Sixteen covariates covering several domains (personal characteristics, education, life-style, early life factors, asthma characteristics and multimorbidities) were selected based on literature and were studied in association with severe asthma using logistic regressions. Results: The study population included 100 (7.4 %) individuals with severe asthma. In a univariate analysis, severe asthma was associated with male sex, age, low education, no professional training, ever smoking, ≥ 2 siblings, ≥ 1 chronic comorbidity and Non-steroidal anti-inflammatory drug (NSAID) -exacerbated respiratory disease (NERD) (p<0.05); and trends for association (p<0.2) were observed for severe childhood infection, presence of chronic rhinosinusitis with nasal polyps, and being the 1st child. The 10 variables (being 1st child was removed due to multicolinearity) were thus entered in a multivariate regression model and severe asthma was significantly associated with male sex (OR [CI95%] = 1.96 [1.16-3.30]), ever smoking (1.98 [1.11-3.52]), chronic comorbidities (2.68 [1.35-5.31]), NERD (3.29 [1.75-6.19]), and ≥ 2 siblings (2.51 [1.17-5.41]). There was a dose-response effect of the total sum of these five factors on severe asthma (OR [CI95%] = 2.30 [1.81-2.93] for each increase of one unit of the score). Conclusions: Male sex, smoking, NERD, comorbidity, age and number of siblings were independent risk factors for self-reported severe asthma. The effects of these factors seem to be additive; each additional risk factor gradually increase with the risk of severe asthma.

show abstract

Birth order and paediatric allergic disease: A nationwide longitudinal survey

Abstract: The influence of birth order depended on the type of allergic disease and the childhood period. Childhood is unique in terms of physical and immunological development, and the immune response to the post-natal environment in childhood appears to be heterogeneous.

Cited by 23 publications

References 34 publications

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study

Parental History of Atopic Diseases and Presence of Allergic Rhinitis and Asthma in Children with Atopic Dermatitis

Risk Factors of Severe Adult-onset Asthma: A Multi-factor Approach

Contact Info

Product

Resources

About