Birth order and neural tube defects: a reappraisal

Vieira, Alexandre R.

doi:10.1016/j.jns.2003.08.014

Cited by 25 publications

(24 citation statements)

References 60 publications

(59 reference statements)

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“…It is very likely that spina bifida and anencephaly share some mechanisms but they should always be considered independent entities (Vieira, 2004). NTDs are considered to be etiologically multifactorial, which require both genetic suspectibility and environmental risk factors.…”

Section: Introductionmentioning

confidence: 99%

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Onrat

Seyman²,

Konuk³

2009

Genet. Mol. Res.

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Section: Introductionmentioning

confidence: 99%

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Onrat

Seyman²,

Konuk³

2009

Genet. Mol. Res.

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“…it is well established that both lower and high maternal age and late birth order have contributed to some birth defects [9][10][11][12][13][14][15][16]. nonetheless, little data is available for children with meningomyelocele (MMC) considering future activity.…”

Section: Family Medicine and Primary Care Review 2016; 18 1 27mentioning

confidence: 99%

The role of selected parental and perinatal factors in the future mobility of children with myelomeningocele

Korzeniecka‐Kozerska¹,

Bagińska²,

Liszewska³

et al. 2016

fmpcr

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A -study Design, B -Data Collection, C -statistical analysis, D -Data interpretation, E -Manuscript Preparation, F -Literature search, G -Funds Collection Background. Myelomenigocele (MMC) is the most severe form of spina bifida, caused by genetic and environmental components; it has many serious complications in a patient's future life, where dysfunctional mobility is one of the most troublesome. Objectives. The aim of our study was to explore the role of selected factors: parental and perinatal in children with myelomenigocele and correlate them with their future motor function. Material and methods. This retrospective analysis was based on 95 births that occurred from 1985 to 2013. Clinical data were collected using medical records and supplemented by a questionnaire for parents. standard deviation of WHo scores (Z-scores) for weight, length, and body mass index (BMi) at birth were calculated. Hoffer's scale was used to assess MMC children's motor function.Results. There were no statistically significant differences between 53 girls and 42 boys who were enrolled in the study, excluding the month of conception. The tested parameters did not vary substantially according to maternal age. Maternal age correlated positively with paternal age at conception, birth order, and stillbirth rate. Mode of delivery was strongly associated with apgar scale and birth weight. apgar score, birth length, and thus WHo Z-score for length-for-age had positive correlations with future mobility of MMC children. Conclusions. 1. Perinatal factors have a significant effect on children's physical activity. 2. There is no clinical evidence that cesarean section improves early neurological outcome of MMC infants. 3. Parental factors, particularly maternal age, do not determine the future mobility of children with myelomeningocele. Key words: myelomeningocele, parental factors, perinatal factors, motor function.Wstęp. Przepuklina oponowo-rdzeniowa jest najcięższą postacią rozszczepu kręgosłupa, której przyczyny mogą być genetyczne i środowiskowe; daje wiele ciężkich powikłań w przyszłym życiu pacjentów, wśród których trudności w poruszaniu się są jednymi z najbardziej uciążliwych. Cel pracy. ocena wybranych czynników: rodzicielskich i okołoporodowych i ich korelacja z czynnością motoryczną dzieci z przepukliną oponowo-rdzeniową. Materiał i metody. Retrospektywnej analizie poddano 95 historii pacjentów objętych opieką w latach od 1985 do 2013. Dane zostały uzupełnione wywiadem od rodziców dzieci. Dla takich parametrów jak: ciężar ciała, długość oraz wskaźnik masy ciała (BMi) w momencie urodzenia wyliczono odchylenia standardowe według WHo. Do oceny czynności motorycznej uży-to skali Hoffera. Wyniki. nie wykazano istotnych statystycznie różnic między 53 dziewczynkami i 42 chłopcami, z wyjątkiem miesiąca urodzenia. Wartości badanych parametrów nie różniły się istotnie w zależności od wieku matki. Wiek matki korelował pozytywnie z wiekiem ojca w momencie poczęcia dziecka, rodzajem porodu i częstością poronień. Rodzaj porodu korelował ze skalą ...

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“…Previous pregnancy has been hypothesized to increase the risk of certain types of defects in human studies, particularly NTDs (specifically spina bifida) (33) and orofacial clefts (34). The effect of increased parity has been controversial, however, with recent studies not finding an effect of parity on these same defects (38).…”

Section: Figure 2 Parity Increases Defects In Twsg1mentioning

confidence: 99%

“…The protective effect of methyl donors on NTD development was previously established in both NTD-susceptible mice (17,71,72) and humans (2,3,7). In contrast to the effect of methyl donor supplementation, increased parity may act to favor NTDs, based on work in humans (33).…”

Section: Figure 2 Parity Increases Defects In Twsg1mentioning

confidence: 99%

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Maternal Diet Supplementation with Methyl Donors and Increased Parity Affect the Incidence of Craniofacial Defects in the Offspring of Twisted gastrulation Mutant Mice

Billington

Schmidt

Zhang

et al. 2013

The Journal of Nutrition

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Diets rich in methyl-donating compounds, including folate, can provide protection against neural tube defects, but their role in preventing craniofacial defects is less clear. Mice deficient in Twisted gastrulation (TWSG1), an extracellular modulator of bone morphogenetic protein signaling, manifest both midline facial defects and jaw defects, allowing study of the effects of methyl donors on various craniofacial defects in an experimentally tractable animal model. The goal of this study was to examine the effects of maternal dietary supplementation with methyl donors on the incidence and type of craniofacial defects among Twsg1 2/2 offspring. Nulliparous and primiparous female mice were fed an NIH31 standard diet (control) or a methyl donor supplemented (MDS) diet (folate, vitamin B-12, betaine, and choline). Observed defects in the pups were divided into those derived mostly from the first branchial arch (BA1) (micrognathia, agnathia, cleft palate) and midline facial defects in the holoprosencephaly spectrum (cyclopia, proboscis, and anterior truncation). In the first pregnancy, offspring of mice fed the MDS diet had lower incidence of BA1-derived defects (12.8% in MDS vs. 32.5% in control; P = 0.02) but similar incidence of midline facial defects (6.4% in MDS vs. 5.2% in control; P = 1.0). Increased maternal parity was independently associated with increased incidence of craniofacial defects after adjusting for diet (from 37.7 to 59.5% in control, P = 0.04 and from 19.1 to 45.3% in MDS, P = 0.045). In conclusion, methyl donor supplementation shows protective effects against jaw defects, but not midline facial defects, and increased parity can be a risk factor for some craniofacial defects.

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Birth order and neural tube defects: a reappraisal

Cited by 25 publications

References 60 publications

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

Incidence of neural tube defects in Afyonkarahisar, Western Turkey

The role of selected parental and perinatal factors in the future mobility of children with myelomeningocele

Maternal Diet Supplementation with Methyl Donors and Increased Parity Affect the Incidence of Craniofacial Defects in the Offspring of Twisted gastrulation Mutant Mice

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