Birth of the Major Histocompatibility Complex

Klein, Jan; Sato, Akie

doi:10.1046/j.1365-3083.1998.00292.x

Cited by 63 publications

(49 citation statements)

References 64 publications

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“…Although the class I and class II loci presumably arose from a single ancestral gene by duplication (2), this presumption does not automatically imply that they were originally together in the same region. Tandem duplication is certainly one possible explanation of their origin, but another is the duplication of the ancestral chromosome bearing the undifferentiated Mhc gene (13). The former possibility is the more parsimonious of the two, because separating into two different parts of the genome is more likely than coming together in the same part of previously separated genes.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in all these taxa, the Mhc segment also contains two other groups of loci. In one group are loci that are structurally unrelated to but functionally involved with the class I loci; in the other are loci that are structurally and functionally unrelated to both the class I and class II loci (13). The former group comprises the proteasome subunit ␤ type (PSMB), 4 the TAP (TAP), and the TAP binding (TAPBP) loci (14).…”

Section: A Contig Map Of the Mhc Class I Genomic Region In The Zebrafmentioning

confidence: 99%

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A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny

Michalová

Murray

Sültmann

et al. 2000

The Journal of Immunology

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In contrast to the human and mouse Mhc, in which the clusters of class I and class II loci reside in close vicinity to one another, in the zebrafish, Danio rerio, they are found in different linkage groups. Chromosome walking using BAC (bacterial artificial chromosome) and PAC (P1 artificial chromosome) clones reveals the zebrafish class I region to occupy a segment of ∼450 kb and to encompass at least 19 loci. These include three class I (Dare-UDA, -UEA, -UFA), five proteasome subunit β (PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A, TAP2B), and one TAP binding protein (TAPBP). This arrangement contrasts with the arrangements found in human and mouse Mhc, in which the orthologues of the PSMB, TAP, and TAPBP loci reside within the class II region. In addition to this main zebrafish class I contig, a shorter contig of about 150 kb contains two additional class I (UBA, UCA) and at least five other loci. It probably represents a different haplotype of part of the class I region. The previously identified UAA gene shares an identical 5′ part with UEA, but the two genes differ in their 3′ parts. One of them is probably the result of an unequal crossing over. The described organization has implications for the persistence of syntenic relationships, coevolution of loci, and interpretation of the origin of the human/mouse Mhc organization.

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Section: Discussionmentioning

confidence: 99%

Section: A Contig Map Of the Mhc Class I Genomic Region In The Zebrafmentioning

confidence: 99%

A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny

Michalová

Murray

Sültmann

et al. 2000

The Journal of Immunology

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“…The identification of these polymorphic MHC genes and also of TCR and Ig genes (6) indicates that the acquired immune system is already complex at the level of fish, although current data indicate that jawed fish form the most primitive group with an MHC/ TCR system (7).…”

mentioning

confidence: 97%

Classical MHC Class I Genes Composed of Highly Divergent Sequence Lineages Share a Single Locus in Rainbow Trout (Oncorhynchus mykiss)

Aoyagi

Dijkstra

Xia

et al. 2002

The Journal of Immunology

127

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The classical MHC class I genes have been known to be highly polymorphic in various vertebrates. To date, putative allelic sequences of the classical MHC class I genes in teleost fish have been reported in several studies. However, the establishment of their allelic status has been hampered in most cases by the lack of appropriate genomic information. In the present study, using heterozygous and homozygous fish, we obtained classical-type MHC class I sequences of rainbow trout (Oncorhynchus mykiss) and investigated their allelic relationship by gene amplification and Southern and Northern hybridization analyses. The results indicated that all MHC class I sequences we obtained were derived from a single locus. Based on this, a unique polymorphic nature of the MHC class I locus of rainbow trout has been revealed. The mosaic combination of highly divergent ancient sequences in the peptide-binding domains is notable, and the variable nature around the boundary between the α3 and transmembrane domains is unprecedented.

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“…Paralogous genes separated by gene duplication events, which has been proposed to be a major force in MHC evolution, while the orthologous genes separated by speciation events. (Klein et al, 1998). The gene duplication has been observed in the genetic organization of MHC genes in many mammals.…”

Section: Phylogenetic Analyses Of Mhc Class II Genes In Cetaceansmentioning

confidence: 99%

“…Genetic and antigenic diversity of the MHC could be important in a host's ability to accommodate rapidly evolving infectious agents that periodically afflict natural populations (Klein & Sato, 1998). Exactly how much MHC diversity is required to ensure long-term population viability remains a fundamental question in conservation genetics.…”

Section: Introductionmentioning

confidence: 99%

Sequence Analysis of MHC Class II Genes in Cetaceans

Yang¹,

Chou²,

Hu³

2012

Histocompatibility

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Birth of the Major Histocompatibility Complex

Abstract: Klein J, Sato A. Birth of the Major Histocompatibility Complex. Scand J Immunol 1998;47:199–209

Cited by 63 publications

References 64 publications

A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny

A Contig Map of theMhcClass I Genomic Region in the Zebrafish Reveals Ancient Synteny

Classical MHC Class I Genes Composed of Highly Divergent Sequence Lineages Share a Single Locus in Rainbow Trout (Oncorhynchus mykiss)

Sequence Analysis of MHC Class II Genes in Cetaceans

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