Birth mode is associated with development of atopic dermatitis in infancy and early childhood

Hoel, Sveinung T.; Wiik, Johanna; Carlsen, Karin C. Lødrup; Endre, Kim M.A.; Guðmundsdóttir, Hrefna; Haugen, Guttorm; Hoyer, Angela; Jonassen, Christine Monceyron; LeBlanc, Marissa; Nordlund, Björn; Rudi, Knut; Skjerven, Håvard Ove; Staff, Anne Cathrine; Hedlin, Gunilla; Söderhäll, Cilla; Vettukattil, Riyas; Aaneland, Hilde; Rehbinder, Eva Maria

doi:10.1016/j.jacig.2023.100104

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Mode of delivery, stood out as a significant factor, with infants delivered vaginally showing a higher odds ratio for AD. Previous research supports that uncomplicated vaginal delivery is protective against allergic diseases, but research is limited for AD [ 33 , 34 , 35 ]. In their study, Mubanga et al, in 1,399,406 children, reported a higher risk of AD when children are delivered by instrumental vaginal delivery, emergency cesarean section, or elective cesarean section [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Nurturing Infants to Prevent Atopic Dermatitis and Food Allergies: A Longitudinal Study

Vassilopoulou,

Rallis,

Milani

et al. 2023

Nutrients

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Background: Atopic dermatitis (AD) at a young age often precedes the development of food allergies. Although AD affects millions of infants worldwide, prenatal and postnatal risk factors, and their association with the development of food allergies later on, are not fully elucidated. This study seeks to investigate AD epidemiology in infancy and its risk factors, examining early-life factors (both prenatal and postnatal) that could contribute to the later development of food allergies. Methods: Between January 2019 and December 2019, 501 infants were included in this prospective cohort study. Longitudinal data collection was performed through maternal interviews, the first one conducted within three days after the delivery and the second within 24 to 36 months after the delivery, encompassing variables such as demographics, family history of atopy, maternal smoking, antibiotic use during pregnancy, the mode of delivery, breastfeeding history, food practices, and greenness exposure within 3 days from delivery, while they were still in the hospital. Results: Maternal smoking during pregnancy (p = 0.001) and an older sibling atopy history (p = 0.03) was significantly linked to AD incidence. Cesarean section delivery (p = 0.04) was associated with a higher risk of food allergies in infants with AD. Having a garden at home correlated with a higher likelihood of AD (p = 0.01), and food elimination without medical guidance (p = 0.02) due to AD correlated with an elevated risk of food allergies. Conclusions: Encouraging timely allergenic food introduction while promoting dietary diversity, rich in plant-based foods, maternal smoking cessation, and professional dietary guidance may help minimize AD and food allergy risk. Future studies should address the role of greenness in the development of AD and food allergies.

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