Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies

Park-Wyllie, Laura; Mazzotta, Paolo; Pastuszak, Anne; Moretti, Myla E; Béïque, L; Hunnisett, Laura; Friesen, Mark; Jacobson, Sheila; Kasapinovic, Sonja; Chang, Debra; Diav–Citrin, Orna; Chitayat, David; Nulman, Irena; Einarson, Thomas R.; Koren, Gideon

doi:10.1002/1096-9926(200012)62:6<385::aid-tera5>3.0.co;2-z

Cited by 803 publications

(283 citation statements)

References 45 publications

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“…This is a steroid prodrug that is activated in the mucosae and is therefore devoid of systemic side effects [45]. In regards to systemic corticosteroids (oral or injected), the data obtained in women with severe asthma, taking high doses of steroids, would suggest a modestly increased risk of cleft lip and pre-eclampsia [46]. Nonetheless, in AR, systemic corticosteroids are recommended only as short courses (3 days) and only to control intractable obstruction [6].…”

Section: Pregnancy Rhinitissupporting

confidence: 83%

Allergic Rhinitis in Women

Passalacqua

2007

Womens Health (Lond Engl)

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Allergic rhinitis is a high-prevalence disease that significantly impairs the quality of life. Its pathogenesis is quite well understood, and involves numerous cells, cytokines and mediators, which result in an inflammatory process. The triggering IgE-mediated reaction does not differ between men and women, but in females some aspects, related mainly to the hormonal frame, must be taken into account. In fact, cyclic hormonal changes can affect the severity of rhinitis, as can pregnancy, which may result in a particular form of ‘pregnancy rhinitis’. The most important and challenging aspect is the management of allergic rhinitis in pregnancy, which require a careful evaluation of the risk:benefit ratio. This review will examine the aforementioned aspects, with particular regard to the pharmacotherapy of rhinitis in pregnancy.

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Section: Pregnancy Rhinitissupporting

confidence: 83%

Allergic Rhinitis in Women

Passalacqua

2007

Womens Health (Lond Engl)

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“…An earlier case-control study of 1092 children born with various congenital anomalies found that women who were exposed to steroids in the month before conception and during the first trimester had a greater prevalence of infants born with orofacial clefts [70]. This was confirmed in a meta-analysis reporting a summary OR of 3.35 (95% CI: 1.97-5.69) for cleft palates, but the overall risk of major malformations was low (OR: 1.45; 95% CI: 0.80-2.60) [71]. Observations from transplant literature suggest steroid use may lead to premature rupture of membranes and adrenal suppression in the mother and, much more rarely, in the newborn.…”

Section: Corticosteroidsmentioning

confidence: 56%

Management of inflammatory bowel disease in pregnancy

Ng¹,

2013

Expert Review of Clinical Immunology

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“…Prednisone does not represent a major teratogenic risk in humans at therapeutic doses. 9 Calibration of steroid therapy is done according to 24 hours' urine protein excretion. Treatment with steroids is often found to be associated with obstetric complications like IUGR, PROM and other infections.…”

Section: Discussionmentioning

confidence: 99%

Maternal and perinatal outcome in a pregnancy with nephrotic syndrome

Mishra

Agarwal

Lamba

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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The influence of pregnancy on the subsequent course of pre-existing nephrotic syndrome is controversial as also the effect of membranous glomerulonephritis on maternal and perinatal outcome. We describe a case of successful pregnancy outcome in Hepatitis B reactive patient with pre-existing nephrotic syndrome (renal biopsy proven case of Membrano-proliferative Glomerulonephritis). She had regular nephrology consultation and her renal disease was well compensated. After sonographic confirmation of live intrauterine pregnancy at 9th gestational week, patient was given methylprednisolone (5mg once daily). Antihypertensive drugs were also given. At 35 weeks of gestation, patient went in labour and cesarean section was performed in view of previous caesarean section. Feto-maternal outcome was good. The intrapartum and postpartum period was uneventful. Renal functions were well preserved. A vigourous healthy 1.93 kg baby was discharged with mother in a stable condition after receiving hepatitis B immunoglobulin.

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Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies

Cited by 803 publications

References 45 publications

Allergic Rhinitis in Women

Allergic Rhinitis in Women

Management of inflammatory bowel disease in pregnancy

Maternal and perinatal outcome in a pregnancy with nephrotic syndrome

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