Birth defects after exposure to misoprostol in the first trimester of pregnancy: Prospective follow-up study

Vauzelle, C.; Beghin, Delphine; Cournot, Maxime; Eléfant, Élisabeth

doi:10.1016/j.reprotox.2012.11.009

Cited by 50 publications

(42 citation statements)

References 19 publications

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“…38,39 Exposure to misoprostol in the first trimester of pregnancy has also been associated with birth defects and congenital trismus. 40 In the case of our patient, there was no radiologic evidence to suggest structural malformations as a possible cause and there was no evidence of birth defects, and the mother denied taking any medications other than prenatal vitamins.…”

Section: Figurementioning

confidence: 56%

“…These commonly include (pre) masseteric fibrous bands, [30][31][32] oral synechiae, 4, 33 distal arthrogryposis, 34 and elongation/hypertrophy of the coronoid process. 35,36 Other causes of congenital trismus include neonatal tetanus, [37][38][39] drug induced, 40 autoimmune, 41 neoplastic, 42 and neurologic (congenital suprabulbar paresis). 43 Neonatal tetanus is still prevalent in the developing world with high morbidity and mortality, but is rare in the Western world.…”

Section: Figurementioning

confidence: 99%

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Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature

et al. 2016

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Trismus refers to any condition inducing limited mouth opening and may present as a result of acquired or congenital pathology. We present the case of a newborn who presented with severe, congenital trismus due to brainstem dysgenesis. We describe the course of his investigations, and a multidisciplinary approach to the management of his care and follow-up. To our knowledge, this is one of the earliest reported cases of congenital trismus attributable to brainstem dysgenesis. A literature review was conducted to provide an overview of the differential pathogenesis as it presents in congenital cases and discuss the complexity of managing congenital trismus due to brainstem dysgenesis in a neonate and infant.

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Section: Figurementioning

confidence: 56%

Section: Figurementioning

confidence: 99%

Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature

et al. 2016

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“…Currently the available data for teratogenic effect misoprostol originate mostly from illegal use for abortion and are mainly retrospective, or more recently prospective follow up studies [25]. This association of the drug and the presenting abnormality in the neonates is dependent on maternal history of drug exposure.…”

Section: Discussionmentioning

confidence: 99%

“…However most of these deformities are reported in retrograde studies, based on positive history of mothers for misoprostol induction [7]. The sparse data of focused experimental studies, with live embryo exposure and control comparison, leaves gaps in facts for establishing the teratogenic effects of misoprostol and other drugs [8].…”

Section: Introductionmentioning

confidence: 99%

Utilizing Chick Embryo in Ovo Model System to Study the Effects of Misoprostol on Early Embryogenesis - A Pilot Study

Zareen

Karim

Akhtar

et al. 2017

JSRT

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Misoprostol, a synthetic prostaglandin E1analogue, is an effective anti-ulcer drug as well as prescription drug for abortion induction. It is also illegally used for unsupervised self-induction of pregnancy termination. However failed abortion, leads to embryo exposure to the drug and is reported to result in congenital anomalies.The current study reports preliminary results of a pilot project designed for evaluating the effects of misoprostol administration on developing chick embryos. The project comprised of two groups of fertilized chicken eggs. The groups were labelled as "A" for control (n=5) and "B" for treated (n = 5) specimens. The treated group embryos were exposed to 4 µg of misoprostol by injecting the drug directly into the yolk sac, while same volume of normal saline was injected in the control group. Whole mount examination of sacrificed embryos after 33 hours of incubation revealed normal stage of development (HH-stage 10) in the control group embryos. While in the treated group, 02 out of 05 embryos lagged in their developmental stage (HH-stage 8), with no brain vesicles formation and lesser number of somite pairs.It is concluded that exposure of developing chick embryos to Misoprostol in a corresponding therapeutic dose of adult females can potentially cause developmental delay and growth regression of the embryos.

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“…The cause of Moebius syndrome is unknown, but rhomboencephalic maldevelopment and brainstem ischemia between 5 to 8 weeks of gestation 3 are two possible etiological hypotheses in children with normal karyotype. The list of potential associated teratogenic events includes hyperthermia, trauma, thrombus formation, embolism, hemorrhage, as well as in utero exposure to various medications including misoprostol 4 . The inheritance patterns of Moebius syndrome are heterogeneous and can be autosomal recessive, autosomal dominant or even X-linked.…”

Section: Introductionmentioning

confidence: 99%

Moebius Syndrome: Challenges of Airway Management

Budić

Surdilovic

Slavkovic

et al. 2016

ACC

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SUMMARY -Moebius syndrome is a rare nonprogressive congenital neurological disorder with a wide range of severity and variability of symptoms. This diversity is a consequence of dysfunction of different cranial nerves (most often facial and abducens nerves), accompanying orofacial abnormalities, musculoskeletal malformations, congenital cardiac diseases, as well as specific associations of Moebius and other syndromes. The authors present anesthesia and airway management during the multiple tooth extraction surgery in a 10-year-old girl with Moebius syndrome associated with Poland and trigeminal trophic syndromes.

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Birth defects after exposure to misoprostol in the first trimester of pregnancy: Prospective follow-up study

Cited by 50 publications

References 19 publications

Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature

Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature

Utilizing Chick Embryo in Ovo Model System to Study the Effects of Misoprostol on Early Embryogenesis - A Pilot Study

Moebius Syndrome: Challenges of Airway Management

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