Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

Ognjanovic, Simona; Carozza, Susan E.; Chow, Eric J.; Fox, Erin E.; Horel, Scott; McLaughlin, Colleen C.; Mueller, Beth A.; Puumala, Susan E.; Reynolds, Peggy; Behren, Julie Von; Spector, Logan G.

doi:10.1038/sj.bjc.6605484

Cited by 48 publications

(41 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased risk of RMS has also been associated with various clinical factors or environmental exposures, including in utero x-ray exposure and accelerated in utero growth [6,7]. However, some of these associations were reported in small to moderate size casecontrol studies and have not been validated in larger epidemiologic studies.…”

Section: Epidemiologymentioning

confidence: 95%

Childhood Rhabdomyosarcoma: New Insight on Biology and Treatment

Huh

Skapek

2010

Curr Oncol Rep

View full text Add to dashboard Cite

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. The two most common histologic variants are the embryonal and alveolar subtypes. Although successive collaborative group clinical trials have improved survival rates for many RMS patients, the outcome for those patients with metastatic or recurrent disease remains poor. Recent studies have pointed to a possible mesenchymal stem cell as the progenitor for alveolar RMS. Other studies have implicated several cellular mechanisms and pathways being involved in RMS pathogenesis and survival, such as the cyclin-dependent kinase inhibitors, insulin-like growth factor pathway, and the mammalian target of rapamycin pathway, thus providing potential avenues for targeted therapy. Recent clinical trials have tried to improve risk stratification and prediction of clinical outcome based upon clinical or radiographic response to initial therapy and also to determine the role of high-dose chemotherapy with stem cell rescue in high-risk RMS patients.

show abstract

Section: Epidemiologymentioning

confidence: 95%

Childhood Rhabdomyosarcoma: New Insight on Biology and Treatment

Huh

Skapek

2010

Curr Oncol Rep

View full text Add to dashboard Cite

show abstract

“…In addition, several studies have evaluated birth characteristics and childhood rhabdomyosarcoma and suggest that increased birth weight [20], increased maternal age [13, 20–22], increased paternal age [20, 22], being born large for gestational age [20], and late or lack of prenatal care [22] are associated with an increased risk of childhood rhabdomyosarcoma. Similar to other childhood cancers, high birth order (3+) is suggested to have a protective effect on childhood rhabdomyosarcoma [9, 20]. A previous report indicated that being born as a twin or a multiple may be associated with higher risk of childhood rhabdomyosarcoma, but this finding was not statistically significant [22].…”

Section: Introductionmentioning

confidence: 99%

“…The largest studies evaluating the association of birth characteristics and childhood rhabdomyosarcoma to date have primarily relied on a large dataset consisting of a pool of cancer registry data linked to birth records from five states across the United States [9, 13, 18, 20, 25]. This pooled dataset has provided sufficient statistical power to assess potential risk factors for rare childhood cancer types, and often their histologic subtypes; however, linkage studies may be subject to selection bias, as children who are born and diagnosed in separate states due to residential mobility are often excluded.…”

Section: Introductionmentioning

confidence: 99%

Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group

Lupo

Danysh

Skapek

et al. 2014

Cancer Causes Control

View full text Add to dashboard Cite

Purpose Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development, however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. Methods This case-control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics (birth weight, preterm birth, and type of delivery (vaginal vs. Cesarean)). Conditional logistic regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n=215) and alveolar (n=66), we evaluated effect heterogeneity of these exposures. Results The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR=1.75, 95% CI=1.12–2.74). Birth control use (OR=1.45, 95% CI=0.96–2.18), anemia during pregnancy (OR=1.27, 95% CI=0.81–1.99), and preterm birth (OR=2.51, 95% CI=0.74–8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight (aOR=4.46, 95% CI=1.41–14.1) and high birth weight (aOR=2.41, 95% CI=1.09–5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p>0.15 for all characteristics). Conclusions Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.

show abstract

“…In addition, mothers delivering macrosomic fetuses are at an increased risk of experiencing prolonged labor, C-section, abnormal hemorrhage and perineal laceration (4,5). Numerous studies have indicated that high birth weight is associated with long-term health risks for the newborn, including an increased risk of obesity, diabetes and certain types of cancer (6)(7)(8)(9). In the past two to three decades, the incidence of macrosomia in developed countries has increased by 15-25% (2).…”

Section: Introductionmentioning

confidence: 99%

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Zhang

Cai

et al. 2016

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Macrosomia, a birth weight ≥4,000 g, is associated with maternal and infant health problems. The dysregulation of microRNAs (miRNAs) in the placenta is associated with adverse birth outcomes, yet whether aberrantly expressed placental miRNAs are associated with macrosomia remains unknown. The aim of the current study was to characterize the expression of three placental miRNAs (miR-6, -21 and -143) and evaluate their association with macrosomia. The miRNA expression in placental tissues from 67 macrosomic pregnancies and 64 normal pregnancies were analyzed using reverse transcription-quantitative polymerase chain reaction. The expression of miR-21 was observed to be elevated in macrosomic placenta compared with control samples, while miR-143 expression was significantly lower than in control placenta (P<0.05). No significant differences were identified in the miR-16 expression levels between the groups (P= 0.955). Following division of miRNA expression levels by quartile, logistic regression models demonstrated that the odds of macrosomia increased with miR-21 expression quartile: Q2, odds ratio (OR)=6.67 [95% confidence interval (CI), 1.39-32.05]; Q3, OR=4.10 (95% CI, 0.88-19.11); Q4, OR=16.19 (95% CI, 2.46-106.68). Conversely, higher levels of miR-143 expression were protective against macrosomia: Q2, OR= 0.22 (95% CI, 0.049-0.98); Q3, OR= 0.11 (95% CI, 0.024-0.55), and Q4, OR= 0.16 (95% CI, 0.032-0.79). Thus, statistical analysis demonstrated that high levels of miR-21 expression and low levels of miR-143 expression predict the risk for macrosomia, indicating an interaction between the two miRNAs. Bioinformatic analysis suggested that they are likely to function in the mitogen-activated protein kinases signaling pathway to influence the risk of macrosomia. The results of the present study provide evidence that placental miR-21 and -143 are important in the formation of macrosomia.

show abstract

Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype

Cited by 48 publications

References 39 publications

Childhood Rhabdomyosarcoma: New Insight on Biology and Treatment

Childhood Rhabdomyosarcoma: New Insight on Biology and Treatment

Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group

Decreased miR-143 and increased miR-21 placental expression levels are associated with macrosomia

Contact Info

Product

Resources

About