Objective The objective of this study was to quantify inter-and intra-observer agreement on classification of the intrapartum cardiotocogram (CTG) and decision to intervene following STAN guidelines.Design A prospective, observational study.Setting Obstetrics Department of a tertiary referral hospital.Population STAN recordings of 73 women after 36 weeks of gestation with a high-risk pregnancy, induced or oxytocinaugmented labour, meconium-stained amniotic fluid or epidural analgesia.Methods Six observers classified 73 STAN recordings and decided if and when they would suggest an intervention. Proportions of specific agreement (P s ) and kappa values (K) were calculated.Main outcome measures Agreement upon classification of the intrapartum CTG and decision to perform an intervention.Results Agreement for classification of a normal and a (pre)terminal CTG was good (P s range 0.50-0.84), but poor for the intermediary and abnormal CTG (P s range 0.34-0.56). Agreement on the decision to intervene was higher, especially on the decision to perform 'no intervention' (P s range 0.76-0.94). Overall inter-observer agreement on the decision to intervene was considered moderate in five of six observer combinations according to the kappa (K range 0.42-0.73). Intra-observer agreement for CTG classification and decision to intervene was moderate (K range 0.52-0.67 and 0.61-0.75).Conclusions Inter-observer agreement on classification of the intrapartum CTG is poor, but addition of information regarding fetal electrocardiogram, especially in case of intermediary or abnormal CTG traces, results in a more standardised decision to intervene.Keywords Cardiotocography, fetal electrocardiogram, inter-and intra-observer agreement, ST analysis.Please cite this paper as: Westerhuis M, van Horen E, Kwee A, van der Tweel I, Visser G, Moons K. Inter-and intra-observer agreement of intrapartum ST analysis of the fetal electrocardiogram in women monitored by STAN. BJOG 2009;116:545-551.