Let λ i , µ j be non-zero real numbers not all of the same sign and let a i , b k be non-zero integers not all of the same sign. We investigate a mixed Diophantine system of the shape0, where d ě 2 is an integer, θ ą d `1 is real and non-integral and τ is a positive real number. For such systems we obtain an asymptotic formula for the number of positive integer solutions px, y, zq " px 1 , . . . , znq inside a bounded box. Our approach makes use of a two-dimensional version of the classical Hardy-Littlewood circle method and the Davenport-Heilbronn-Freeman method. The proof involves a combination of essentially optimal mean value estimates for the auxiliary exponential sums, together with estimates stemming from the classical Weyl and Weyl-van der Corput inequalities.