Birch Pollen-Related Food Allergy: An Excellent Disease Model to Understand the Relevance of Immunological Cross-Reactivity for Allergy

Subbarayal, Brinda; Geroldinger‐Simic, Marija; Bohle, Barbara

doi:10.5772/26764

Cited by 4 publications

(5 citation statements)

References 77 publications

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“…The allergens contained in these foods not only elicit allergic reactions in the gastrointestinal tract but also often cause urticaria, atopic dermatitis, and bronchial obstruction. With a few exceptions, most children outgrow class 1 food allergy within the first 3 to 6 years of life [ 7 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

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Oral Allergy Syndrome: An Update for Stomatologists

Kashyap¹,

Kashyap

2015

Journal of Allergy

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Oral allergy syndrome (OAS) is an allergic reaction in the oral cavity subsequent to the consumption of food such as fruits, nuts, and vegetables. It occurs mainly due to homology of proteins of pollen to the proteins of fruits and vegetables. In OAS, the immune system produces antibodies that are directed against the proteins of pollen and structurally similar proteins in food, hence, resulting in allergic symptoms limited mainly to the oral cavity. In this review, we have summarized the etiopathogenesis, clinical features, diagnosis, and management of OAS as an update for stomatologists.

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Section: Etiopathogenesismentioning

confidence: 99%

“…This form of food allergy is believed to be a consequence of immunological cross-reactivity between respiratory allergens and structurally related proteins in the respective foods. OAS belongs to this group [ 7 ].…”

Section: Etiopathogenesismentioning

confidence: 99%

Oral Allergy Syndrome: An Update for Stomatologists

Kashyap¹,

Kashyap

2015

Journal of Allergy

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“…5−8 The allergy usually manifests as the oral allergy syndrome (OAS), which involves itching of the lips, tongue, and throat and is sometimes accompanied by oedema of the lips and tongue. 9 Although the reaction is rather mild, allergy sufferers often avoid the consumption of fresh apples. This is impairing their nutrition because apples are an important aspect in a Western diet due to their beneficial composition and their year-round availability.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Well-known examples of cross-allergic reactions are among the birch pollen allergen Bet v 1 and proteins in various fruits such as apples (allergen Mal d 1) or cherries (Pru v 1) . In Europe 50–80% of all birch pollen allergy sufferers are estimated to be affected by food cross-allergy. − The allergy usually manifests as the oral allergy syndrome (OAS), which involves itching of the lips, tongue, and throat and is sometimes accompanied by oedema of the lips and tongue . Although the reaction is rather mild, allergy sufferers often avoid the consumption of fresh apples.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

Kaeswurm

Straub

Siegele³

et al. 2023

J. Agric. Food Chem.

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The apple allergy in Northern Europe is a cross-reaction to the birch pollen allergy. No correlation between the allergenicity of an apple variety and the content of the major apple allergen Mal d 1, a homologue to the Bet v 1 allergen in birch, could be found using ELISA, so far. Therefore, an impact of polyphenols and/or differences in the isoallergen profile are discussed. To allow a more detailed analysis of the Mal d 1 content and the isoallergen profile, a mass spectrometric method was applied to investigate differences in the flesh and peel of 10 traditional varieties and 10 commercial breeds. The data revealed often, but not always, lower Mal d 1 contents in traditional varieties grown in orchard meadows, which was more obvious in the flesh. Differences among the peels were less pronounced. A closer look at the individual isoallergens 1.01, 1.02, 1.03, and 1.06 reveals an increased impact of the minor isoallergens 1.03 and 1.06 on the allergenic potential, since commercial breeds like Braeburn, Santana, and Holstein Cox, which are considered to have reduced allergenic potentials, were characterized by low levels of these isoallergens.

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“…The most common are plants from the family Rosaceae and Apiaceae. Similarities in amino acid sequences were found in different plants and foods [20,21] but a fruit similarity prevails ( Table 1). Most often, allergens are located in fruit pulp.…”

Section: Introductionmentioning

confidence: 90%

Application of Genomic Data for PCR Screening of Bet v 1 Conserved Sequence in Clinically Relevant Plant Species

Žiarovská¹,

Zeleňáková²

2019

Systems Biology

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Bet v 1 is a highly immunogenic protein, which is the main cause of sensitivity to birch pollen and is described as the main birch allergen. Despite the structural similarity, Bet v 1 homologs show different properties and immunoreactivity. Here, the bioinformatic algorithms were applied for known Bet v 1 homologous nucleic acids sequences to find homology and conserved regions. Genomic sequences of PR proteins of two different fruit species, which allergens belong to PR proteins of the same type as Bet v 1, were selected to design degenerate primers. Subsequently, screening of the presence of Bet v 1 conserved genomic sequence was performed in 45 clinically relevant plant species.

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Birch Pollen-Related Food Allergy: An Excellent Disease Model to Understand the Relevance of Immunological Cross-Reactivity for Allergy

Cited by 4 publications

References 77 publications

Oral Allergy Syndrome: An Update for Stomatologists

Oral Allergy Syndrome: An Update for Stomatologists

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

Application of Genomic Data for PCR Screening of Bet v 1 Conserved Sequence in Clinically Relevant Plant Species

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