Bipyridine hydrogel for selective and visible detection and absorption of Cd²⁺

Abstract

Herein, we report for the first time the use of bipyridine-based hydrogel for selective and visible detection and absorption of Cd(2+). At low concentrations, hydrogelator 1 was applied for selective detection of Cd(2+) in vitro and in living cells with high sensitivity. In the absence of metal ions, 1 is nonfluorescent at 470 nm. Upon addition of metal ions, 1 selectively coordinates to Cd(2+), causing an 86-fold increase of fluorescence intensity at 470 nm via the chelation enhanced fluorescence (CHEF) effect, as revealed by first-principles simulations. At 1.5 wt% and pH 5.5, 1 self-assembles into nanofibers to form hydrogel Gel I. Since Cd(2+) could actively participate in the hydrogelation and promote the self-assembly, we also successfully applied Gel I for visible detection and absorption of Cd(2+). With these excellent properties, Gel I is expected to be explored as one type of versatile biomaterial for not only environmental monitoring but also for pollution treatment in the near future.

Synthesis and characterization of alternating copolymers containing bipyridine and phenylene vinylene for fluorescent chemosensors

“…Fluorescent polymers in combination with receptors such as crown ether, terpyridine, bi‐imidazole, and bipyridine have been demonstrated to show several advantages for sensing applications compared to small molecules . Nitrogen‐based ligands such as 2,2′‐bipyridine and other multidentate ligands have been used extensively as metal‐chelating ligands because of their effective coordination with a variety of metal ions . The emission intensity of fluorescent conjugated polymers dramatically decreases as a turn‐off sensor under photon irradiation if the exciton can rapidly migrate along the polymer backbone to the 2,2′‐bipyridine site.…”

Recent Progress in Fluorescent Probe for the Detection of Reactive Carbonyl Species

“…Murphy 等 [55] 采用邻苯二甲胺作为甲基乙二醛和乙二醛的反应位点, 连接三苯基膦定位基团合成了探针 22(如 Scheme 7 所 示). 作者发现, 化合物 超分子水凝胶具有生物相容性和可降解性等 [57] 优 势, 被广泛用于伤口愈合 [58] , 药物释放 [59] 以及组织工程 等 [60] 领域, 近年来, Liang 及其课题组 [61] 设计合成了基 于联吡啶的超分子凝胶用于可以检测 Cd 2＋ , 并且伴随 着选择性好和灵敏度高的特征, 为这一技术在分析检测 领域的应用提供了基础. 类似地, 2016 年, Liang 等 [62] 基 于邻苯二甲胺与甲基乙二醛具有较高的反应活性, 设计 合成了一种水凝胶前体 24 (如 Eq.…”

Facile Synthesis of Galactosamine‐Stabilized Gold Nanoparticles with Sensitive Cd2+ Sensing

“…[9][10][11] Recently, Jiang and co-workers exploited a bipyridine hydrogel, which was applied for the selective detection of Cd 2+ ions in vitro and in living cells with high sensitivity over the range 4-18 μm (limit 21 nm). [12] Inductively coupled plasma mass spectrometry, [13] selective cold vapor atomic fluorescence spectrometry, [14] and colorimetric assays are possible tools for monitoring the level of cadmium. [15,16] These assays allow the transformation of target sensing events into color changes, which have the potential for in-the-field application through naked-eye detection.…”

“…Electroanalytical methods have been developed to determine concentrations of Cd 2+ ions with a high detection limit (Table S1) 9–11. Recently, Jiang and co‐workers exploited a bipyridine hydrogel, which was applied for the selective detection of Cd 2+ ions in vitro and in living cells with high sensitivity over the range 4–18 μ M (limit 21 n M ) 12…”