Bipyrazole Based Novel Bimetallic µ-oxo Bridged Au(III) Complexes as Potent DNA Interacalative, Genotoxic, Anticancer, Antibacterial and Cytotoxic Agents

Synthetic Routes to Bioactive Bipyrazole Derivatives

“…[29] Recently, bipyrazole-based metal coordination compounds displayed interesting applications as pharmaceuticals and in material science. For example, gold(III) and ruthenium(II) complexes of bipyrazoles were proved to be anticancer agents, [30,31] and copper(I) complexes had excellent anti-bacterial activity, [32] whereas gold(III), platinum(II), osmium(II) and copper(I) complexes were involved in fabrication of luminescence Organic Light-Emitting Diodes (OLED) and laser materials, [33][34][35][36][37] Furthermore, 4,4'-bipyrazoles were participated in the synthesis of flexible metal-organic framework (MOF) materials with pronounced applications, for example Co(4,4'bipyrazolate) possesses notable advantage of long-term stability to air and moisture and useful as selective adsorption separation of carbon dioxide, [38] and as heterogeneous catalysts in cumene aerobic oxidation [39] and Cu(4,4'-bipyrazolate) MOF were highly selective in binding acetylene versus carbon dioxide. [40] Bipyrazoles (especially Bippyphos) played an important role as ligands for palladium-catalyzed cross-coupling reactions of aryl halides.…”