Bipolar tetraether archaeosomes exhibit unusual stability against autoclaving as studied by dynamic light scattering and electron microscopy

Brown, Desmond; Venegas, Berenice; Cooke, Peter; English, Verrica; Chong, Parkson Lee‐Gau

doi:10.1016/j.chemphyslip.2009.03.004

Cited by 48 publications

(43 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to high thermo-stability archaeosomes formulations can be sterilized by autoclaving (Brown et al, 2009). Archaeal lipids have more thermo-labile stability in environment (Brown et al, 2009). The phagocytic cells uptake is greater which ensures good adjuvant activity (Krishnan & Dennis Sprott, 2003).…”

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

“…It can be used for specific organ targeting (Patel & Chen, 2006). The bipolar lipids enhance their stability properties hence they can be prepared and stored in the presence of air/oxygen without any degradation (Brown et al, 2009). Due to high thermo-stability archaeosomes formulations can be sterilized by autoclaving (Brown et al, 2009).…”

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

“…Uni-or-oligo lamellar archaeosome can obtain using this method (Kaur et al, 2014f). For example, UL vesicles were generated from ML vesicles by extrusion 10 times using a lipid extruder (Lipex, Vancouver, Canada) at the desired temperature (65 C for archaeosomes) through two stacked polycarbonate membranes (pore size ¼ 200 nm) under nitrogen gas pressure (Brown et al, 2009).…”

Section: French Pressure Cell Extrusionmentioning

confidence: 99%

“…The bipolar lipids enhance their stability properties hence they can be prepared and stored in the presence of air/oxygen without any degradation (Brown et al, 2009). Due to high thermo-stability archaeosomes formulations can be sterilized by autoclaving (Brown et al, 2009). Archaeal lipids have more thermo-labile stability in environment (Brown et al, 2009).…”

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

See 3 more Smart Citations

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

View full text Add to dashboard Cite

Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

show abstract

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

Section: French Pressure Cell Extrusionmentioning

confidence: 99%

Section: Advantages Of Archaeal Lipidsmentioning

confidence: 99%

See 2 more Smart Citations

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Unlike the tetraether lipids, which can form simple monolayers due to their bipolarity, monopolar C 25,25 lipids form bilayers. The unique structures and properties of bipolar tetraether lipids have been extensively studied [4,5]. However, it has been shown that the cell membrane of A. pernix and liposomes prepared solely from these C 25,25 lipids, known as archaeosomes, have some unique properties [6,7].…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of liposomes made of diether archaeal lipids and dipalmitoyl-L-α-phosphatidylcholine

Gmajner¹,

Grabnar²,

Žnidarič³

et al. 2011

Biophysical Chemistry

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D

show abstract

Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT‐0 (Isocaldarchaeol)**

et al. 2021

View full text Add to dashboard Cite

Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature.T hese amphiphiles are the major constituents of the membranes of numerous Archaea, some of which are extremophilic organisms.D ue to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However,these studies have thus far been hampered by limited access to chemically pure samples.Herein, we report aconcise and stereoselective synthesis of the archaealt etraether lipid parallel GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.

show abstract

Bipolar tetraether archaeosomes exhibit unusual stability against autoclaving as studied by dynamic light scattering and electron microscopy

Cited by 48 publications

References 34 publications

Archaeosomes: an excellent carrier for drug and cell delivery

Archaeosomes: an excellent carrier for drug and cell delivery

Structural characterization of liposomes made of diether archaeal lipids and dipalmitoyl-L-α-phosphatidylcholine

Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT‐0 (Isocaldarchaeol)**

Contact Info

Product

Resources

About