Bipolar Symptoms in Adult Attention-Deficit/Hyperactivity Disorder

Halmøy, Anne; Halleland, Helene Barone; Dramsdahl, Margaretha; Bergsholm, Per; Fasmer, Ole Bernt; Haavik, Jan

doi:10.4088/jcp.08m04722ora

Cited by 61 publications

(37 citation statements)

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“…More recent studies have been critical to this diagnostic specificity [46], and have even shown an overlap between MDQ and ADHD reported symptoms [40,47]. We therefore decided to use the more global term of affective fluctuations to describe the functionally impairing symptoms assessed by the MDQ, and strict criteria to define affective fluctuation in order to distinguish MDQ symptoms from ADHD symptoms.…”

Section: Methodsmentioning

confidence: 99%

“…This may be explained by the heightened arousal characterizing individuals with affective disorders [38], and that this arousal contributes to cognitive impairment through its effect on EF [39]. Due to the high frequency of affective symptoms in adults with ADHD [40], these results motivate further studies using the ANT to investigate characteristics of alerting and control networks.…”

Section: Introductionmentioning

confidence: 99%

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Attention Network Test in adults with ADHD - the impact of affective fluctuations

et al. 2011

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BackgroundThe Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls on measures of accuracy, variability and vigilance as well as the control network. Secondly, we studied subgroups of adults with ADHD, expecting impairment on measures of the alerting and control networks in a subgroup with additional symptoms of affective fluctuations.MethodsA group of 114 adults (ADHD n = 58; controls n = 56) performed the ANT and completed the Adult ADHD Rating Scale (ASRS) and the Mood Disorder Questionnaire (MDQ). The latter was used to define affective fluctuations.ResultsThe sex distribution was similar in the two groups, but the ADHD group was significantly older (p = .005) and their score on a test of intellectual function (WASI) significantly lower than in the control group (p = .007). The two groups were not significantly different on measures of the three attention networks, but the ADHD group was generally less accurate (p = .001) and showed a higher variability through the task (p = .033).The significance was only retained for the accuracy measure when age and IQ scores were controlled for. Within the ADHD group, individuals reporting affective fluctuations (n = 22) were slower (p = .015) and obtained a lower score on the alerting network (p = .018) and a higher score on the conflict network (p = .023) than those without these symptoms. The significance was retained for the alerting network (p = .011), but not the conflict network (p = .061) when we controlled for the total ASRS and IQ scores.DiscussionAdults with ADHD were characterized by impairment on accuracy and variability measures calculated from the ANT. Within the ADHD group, adults reporting affective fluctuations seemed to be more alert (i.e., less impacted by alerting cues), but slower and more distracted by conflicting stimuli than the subgroup without such fluctuations. The results suggest that the two ADHD subgroups are characterized by distinct patterns of attentional problems, and that the symptoms assessed by MDQ contribute to the cognitive heterogeneity characterizing groups of individuals with ADHD.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attention Network Test in adults with ADHD - the impact of affective fluctuations

et al. 2011

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“…Other important comorbid conditions include anxiety (Edel et al 2009;Dineen andGallagher 2009), bipolar disorders (Bernardi et al 2009;Halmoy et al 2009) oppositional defiant and conduct disorder (Alvaani and Dalvand 2009;Franc et al 2009) and substance use (Feuz and Tschacher 2009).…”

Section: Differential Diagnosis and Comorbiditymentioning

confidence: 98%

The current status of research into attention deficit hyperactivity disorder: proceedings of the 2nd international congress on ADHD: from childhood to adult disease

Thome

Reddy

2009

ADHD Atten Def Hyp Disord

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Despite being a devastating psychiatric condition with high prevalence, ADHD has traditionally been widely under-researched, specifically in adult patients. Therefore, the recent surge in scientific projects focusing on ADHD is impressive. By reviewing selected research findings presented at the 2nd International Congress on ADHD, this paper gives an overview about current state-of-the art research in such different areas as diagnosis, classification, epidemiology, differential diagnosis and comorbidity, neurobiology (including molecular genetics, proteomics, neuroimaging and electrophysiology), environmental factors, modelling of ADHD, treatment (pharmacological and non-pharmacological), as well as forensic and social aspects.

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“…All studies were carried out in accordance with the tenets of the Declaration of Helsinki and were approved by the respective local Norwegian, German, Danish and British local research ethical committees; see [30], [31], [32], [33], [34], [35], [36]. Written informed consent was given by all participants and in case of minors by their parents.…”

Section: Methodsmentioning

confidence: 99%

“…A sample of 466 Norwegian cases and 515 controls [31] was genotyped for markers covering the DCLK1 gene. For this sample we chose to genotype the markers (n = 20) that had been selected for the replication study in the BP sample.…”

Section: Methodsmentioning

confidence: 99%

DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder

et al. 2012

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Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4×10−5 and 4×10−6, respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3′UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.

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Bipolar Symptoms in Adult Attention-Deficit/Hyperactivity Disorder

Abstract: Our findings illustrate the close relationship between some symptoms of BSD and ADHD in adults. In clinical and research settings, patients screening positive for BSD should be assessed for a possible underlying or coexisting ADHD condition and vice versa.

Cited by 61 publications

References 58 publications

Attention Network Test in adults with ADHD - the impact of affective fluctuations

Attention Network Test in adults with ADHD - the impact of affective fluctuations

The current status of research into attention deficit hyperactivity disorder: proceedings of the 2nd international congress on ADHD: from childhood to adult disease

DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder

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