Bipolar Spectrum Disorder: A Pilot Study

Ghaemi, S. Nassir; Hsu, Douglas J.; Ko, James Y.; Baldassano, Claudia F.; Kontos, Nicholas; Goodwin, Frederick K.

doi:10.1159/000080717

Cited by 45 publications

(24 citation statements)

References 18 publications

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“…Specifically, among those women given a diagnosis of unipolar depression upon first presentation, women who presented in the postpartum period had a relative risk of 2.88 (95% CI 1.51–5.92) of a subsequent BPD diagnosis, compared to women presenting at any other time. Another study that compared depressive symptoms in BPD patients to unipolar patients found a greatly increased reporting of a postpartum episode in BPD patients compared to unipolar (OR = 7.9 95% CI 0.8 – 378.1)(Ghaemi et al, 2004). However, the small sample size of the study meant that the null hypothesis of equality of postpartum episodes could not be rejected.…”

Section: Discussionmentioning

confidence: 99%

Applying polygenic risk scores to postpartum depression

Byrne

Carrillo-Roa

Penninx

et al. 2014

Arch Womens Ment Health

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Objective The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis. Method We assembled a total cohort of 1,420 self-report cases of PPD and 9,473 controls with genome-wide genotypes from Australia, the Netherlands, Sweden and the United Kingdom. We estimated the total variance attributable to genotyped variants. We used association results from the Psychiatric Genomics Consortia (PGC) of Bipolar Disorder (BPD) and MDD to create polygenic scores in PPD and related MDD data sets to estimate the genetic overlap between the disorders. Results We estimated that the percentage of variance on the liability scale explained by common genetic variants to be 0.22 with a standard error of 0.12, p = 0.02. The R2 from a logistic regression of PPD case-control status in all four cohorts on a SNP profile score weighted by PGC-BPD association results was small (0.1%) but significant (p= 0.004) indicating a genetic overlap between BPD and PPD. The results were highly significant in the Australian and Dutch cohorts (R2 > 1.1%, p < 0.008), where the majority of cases met criteria for MDD. The genetic overlap between BPD and MDD was not significant in larger Australian and Dutch MDD case-control cohorts after excluding PPD cases (R2 =0.06%, p= 0.08), despite the larger MDD group affording more power. Conclusions Our results suggest empirical genetic evidence for a more important shared genetic etiology between BPD and PPD, than between BPD and MDD.

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Section: Discussionmentioning

confidence: 99%

Applying polygenic risk scores to postpartum depression

Byrne

Carrillo-Roa

Penninx

et al. 2014

Arch Womens Ment Health

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“…Bunlar arasında erken yaşta başlangıç, bipolar bozukluk yönünden pozitif aile öyküsü, atipik belirtiler, psikotik bulgu, yineleyici ve kısa depresyonlar, postpartum başlangıç, hipertimik mizaç, antidepresan toleransı ya da yanıtsızlık, manik kayma sayılabilir. [42] Hem tanı alana dek geçen süreyi uzatması hem de önceki yanlış tanı oranını arttırması yönünden bir diğer risk, hipomanik atakların atlanması, atlanmadığı yerde de geriye dönük tanılandırmanın güvenilirliğinin düşüklüğüdür. Bu engel ve kısıtlılığı ortadan kaldırmaya yönelik önlem ve öneri, hipomaninin bir ölçüm aracı ile taranması ve gelecek tanılandırma sistemlerinde duygudurum yerine psikomotor aktivite ölçütlerine ağırlık verilmesidir.…”

Section: Başlangıç Yaşı Ve Tanıunclassified

Bipolar disorder in Turkey: A review

Gültekin¹,

Kesebir²,

Tamam³

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetTürkiye'de bipolar bozukluk ile ilgili yapılmış çalışmaların incelenmesinde epidemiyolojik anlamda nitelikli alan çalışmasına rastlanmamıştır. Çalışmaların çoğu, hastane başvurusu kaynaklı ve klinik çalışmalardır, sistematik bir tarama içermemekte, epidemiyolojik veri toplama ya da sağlık hizmetlerine bilgi aktarma amaçlı değildir. Bu çalışmaların bulgularının toplumumuza genellenebilirliği geçerli ve güvenilir olmaktan uzaktır. Bununla birlikte, ülkemizin değişik bölgelerinde yapılmış çalışmaların bulgularının gözden geçirilerek oluşturulacak bir profilin hastalığın bize özgü özellikle-rinin tanınmasına ve risk etkenlerinin saptanmasına katkısı olacaktır. Tüm bu bilgiler bipolar bozukluk ile ilgili olarak, toplum ruh sağlığı hizmetlerinin oluşturulup geliştirilmesine temel oluştu-rabilir. Ülkemizde epidemiyolojik anlamlılığı olan, çok merkezli, toplum örneklemli ve geniş katılım-lı çalışmalara gereksinimi vardır. Psikiyatrik epidemiyoloji ve klinik araştırmalarımız gerekli bilimsel bazı bulundurmakla birlikte, hızlı kentleşme ve göç gibi toplumsal, özgün ve gelişimsel ilişkileri değerlendirebilecek güçte değildir. Bu gözden geçirmede, Türkiye'de bipolar bozukluk ile ilgili yapılmış çalışmalarda, öne çıkan epidemiyolojik bulguların, eksikliklerin ve gelecekte konuyla ilgili neler yapılabileceğinin araştırılarak tartışılması amaçlanmıştır.Anahtar sözcükler: Bipolar bozukluk, epidemiyoloji, Türkiye. AbstractAssessment of studies related with bipolar disorder in Turkey did not reveal an epidemiologically qualified field study. Most of the studies are hospital based or clinical studies which did not include a systematical scanning and did not aim to collect any epidemiological data and transfer information to health authorities. The generalizability of these studies to our community is far from being valid and reliable. On the other hand, a profile which will be created by reviewing the findings of these studies performed in various regions of Turkey will have a contribution to knowing the "unique to us" features of bipolar disorder and determining cultural risk factors. All this information can constitute a basis for formation and development of public mental health services related with bipolar disorder. In Turkey, the need for epidemiologically significant, polycentric, public sampled studies with broad participation is indispensable. Although our psychiatric epidemiology and clinical studies include necessary scientific basis, they are not powerful enough to evaluate the authentic and progressional relations such as rapid urbanization and immigration. The aim of this review is to evaluate and discuss prominent epidemiological findings, deficiencies and possibile future activities related with studies conducted in Turkey about bipolar disorder..

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“…Thus, several neuropsychiatric disorders are expressed by the penchance for immediate gratification of ongoing desire at the expense of long-term considerations and are thereby characterised by a lack of proficiency in decision-making and impulsive choice behaviour (cf., First et al, 1996;Bulik et al, 1997;Soloff et al, 2000;Mitchell et al, 2002;Swann et al, 2004;2005;2007). In this regard, bipolar disorder, a highly debilitating condition (Murray and Lopez, 1996), with serious suicide risk (Baldessarini and Tondo, 2003) and, in particular, diagnostic dilemma (Manning, 2003;Ghaemi et al, 2004;Bowden, 2005;Swann, 2006). Nevertheless, there exists a plethora of evidence for functional abnormality in several brain regions, including the amygdala, anterior cingulate cortex, striatum, hippocampus and, in the context of impulsive behaviour , the dorsolateral prefrontal cortex (Altshuler et al, 1998;Adler et al, 2004;Gruber et al, 2004;Lawrence et al, 2004;Blumberg et al, 2005;Malhi et al, 2005Malhi et al, , 2007Lapopoulis et al, 2007;Wessa et al, 2007).…”

Section: Impulsiveness In Depressive Statesmentioning

confidence: 99%

Affective status in relation to impulsive, motor and motivational symptoms: Personality, development and physical exercise

et al. 2008

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The contributions of impulsive and risk-taking behaviour in depressive and bipolar disorders, motivational and motor behaviours in anhedonic and substance addictive states, and the factors, particularly distress and trauma, underlying the development of neuropathology in affective status are described from clinical, epidemiological and laboratory perspectives. In order to distinguish one case factor for biopsychological substrates of health, an array of self-reported characteristics, e.g., positive or negative affect, stress or energy, optimism, etc., that may be predictive or counterpredictive for the propensity for physical exercise and activity were analysed using a linear regression in twelve different studies. Several individual characteristics were found to be markedly and significantly predictive of the exercise propensity, i.e., positive affect, energy, health-seeking behaviour and character, while optimism was of lesser, though significant, importance. Several individual characteristics were found to be significantly counterpredictive: expression of BDI- and HAD-depression, major sleep problems and lack/negligence of health-seeking behaviour. The consequences of physical activity and exercise for both affective well-being, cognitive mobility and neurogenesis is noted, particularly with regard to developmental assets for younger individuals. Affective disorder states may be studied through analyses of personal characteristics that unfold predispositions for symptoms-profiles and biomarkers derived from properties of dysfunction, such as impulsiveness, temperament dimensions, anhedonia and 'over-sensitivity', whether interpersonal or to reward.

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Bipolar Spectrum Disorder: A Pilot Study

Cited by 45 publications

References 18 publications

Applying polygenic risk scores to postpartum depression

Applying polygenic risk scores to postpartum depression

Bipolar disorder in Turkey: A review

Affective status in relation to impulsive, motor and motivational symptoms: Personality, development and physical exercise

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